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Alpha-Blockers For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion To summarize, the treatment of hypertension is a critical aspect of healthcare due to its significant impact on cardiovascular health. While natural supplements and lifestyle modifications are important for overall well-being, the use of chemical drugs in managing hypertension remains necessary. Chemical drugs for hypertension have undergone extensive research and have been proven effective in lowering blood pressure levels. Alpha-blockers offer a targeted approach to address the specific mechanisms involved in hypertension, allowing for precise blood pressure control. They work by inhibiting the ...
Source: The EMT Spot - July 17, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

How Are Keloids Treated?
Discussion Wound healing is a complex process and abnormalities are common. Hypertrophic or keloid scarring are the two types of excessive scarring with both having excessive scar tissue that is elevated above the normal skin. Hypertrophic scarring occurs usually only within the wound and can regress. They are common after burns and develop within 3 months of skin injury. Keloid scarring spreads beyond the original wound and does not regress, and often recur. They can occur even 1 year after injury. Keloids have an incidence of 5-15%. “Compared to normal fibroblasts, keloidal fibroblasts have longer lives, higher pro...
Source: PediatricEducation.org - July 17, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Comparative evaluation of treatment outcome of partial pulpotomy using different agents in permanent teeth —a randomized controlled trial
ConclusionPartial pulpotomy when performed following evidence-based guidelines results in high success rates regardless of capping agent employed. EMD can be considered a valid and suitable pulp capping agent in PP.Clinical relevanceMeticulous examination and removal of superficially inflamed pulp under magnification and complete asepsis lead to successful pulpal healing regardless of capping agent employed.
Source: Clinical Oral Investigations - July 17, 2023 Category: Dentistry Source Type: research

T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions
Neuropathic pain can appear as a direct or indirect nerve damage lesion or disease that affects the somatosensory nervous system. If the neurons are damaged or indirectly stimulated, immune cells contribute significantly to inflammatory and neuropathic pain. After nerve injury, peripheral macrophages/spinal microglia accumulate around damaged neurons, producing endogenous hydrogen sulfide (H2S) through the cystathionine-γ-lyase (CSE) enzyme. H2S has a pronociceptive modulation on the Cav3.2 subtype, the predominant Cav3 isoform involved in pain processes. The present review provides relevant information about H2S modulati...
Source: Frontiers in Pharmacology - July 17, 2023 Category: Drugs & Pharmacology Source Type: research

The G protein-coupled estrogen receptor of the trigeminal ganglion regulates acute and chronic itch in mice
CONCLUSION: Our findings demonstrated that the GPER of TG neurons is involved in the regulation of acute and chronic itch perception, by modulating the function of TRPA1 and TRPV1. This study provides new insights into peripheral itch sensory signal processing mechanisms and offers new targets for future clinical antipruritic therapy.PMID:37452499 | DOI:10.1111/cns.14367
Source: CNS Neuroscience and Therapeutics - July 15, 2023 Category: Neuroscience Authors: Jun Li Po Gao Siyu Zhang Xiaoqi Lin Junhui Chen Song Zhang Yingfu Jiao Weifeng Yu Xiaoqiong Xia Liqun Yang Source Type: research

Notch signaling pathway: a new target for neuropathic pain therapy
AbstractThe Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110  years ago and has been found to play a crucial role in the development of multicellular organisms. Notch receptors and their ligands are single-pass transmembrane proteins that typically require cellular interactions and proteolytic processing to facilitate signal transduction. Recently, mounting evidence has shown that aberrant activation of the Notch is correlated with neuropathic pain. The activation of the Notch signaling pathway can cause the activation of neuroglia and the release of pro-inflammatory factors, a key mech...
Source: The Journal of Headache and Pain - July 15, 2023 Category: Neurology Source Type: research

Ketoprofen in horses: Metabolism, pharmacokinetics, and effects on inflammatory biomarkers
This study represents a comprehensive examination of the metabolism (in vivo and in vitro), pharmacokinetics and ex vivo pharmacodynamics, of ketoprofen in horses. The in vitro metabolism as well as specific enzymes responsible for metabolism was determined by incubating liver microsomes and recombinant CYP450 and UGT enzymes with ketoprofen. For the in vivo portion, 15 horses were administered a single intravenous dose of 2.2-mg/kg ketoprofen. Blood and urine samples were collected prior to and up to 120  h post-drug administration. Additional blood samples were collected at select time points and were stimulated with c...
Source: Drug Testing and Analysis - July 14, 2023 Category: Drugs & Pharmacology Authors: Heather K. Knych, Daniel S. McKemie, Philip H. Kass, Scott D. Stanley, Jeff Blea Tags: RESEARCH ARTICLE Source Type: research

Effects of Teriparatide on Clinical and Radiologic Long-Term Outcomes after Fixation of Pertrochanteric Hip Fractures
CONCLUSIONS: The current study illustrated that short-term daily administration of teriparatide improves long-term functional outcome after pertrochanteric hip fracture fixation and can reduce the pain but does not affect union and callus formation.PMID:37434941 | PMC:PMC10331546 | DOI:10.4103/abr.abr_127_22
Source: Biomed Res - July 12, 2023 Category: Research Authors: Mehdi Hosseini Khameneh Mona Gorji Meisam Jafari Kafi-Ababdi Farsad Biglari Morteza Gholipour Keivan Asadi Amir Sabbaghzadeh Source Type: research

Angiotensin II Receptor Blockers (ARBs) For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion Cardiovascular disease (CVD) has become a leading cause of death globally, necessitating the adoption of preventive measures, early detection, and effective management strategies. Hypertension, a significant risk factor for CVD, requires active management to mitigate associated risks. Angiotensin II Receptor Blockers (ARBs) have emerged as a favored choice among healthcare professionals due to their effectiveness and unique benefits. ARBs offer several advantages compared to other blood pressure medications. They effectively control blood pressure, protect vital organs such as the heart and kidneys, ...
Source: The EMT Spot - July 11, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

A case of tracheobronchopathia ostochondorplastica
We present an interesting case of a 55  year old man who presented with history of weight loss, cough and right sided chest pain. CT showed right upper lobe cavity. He was evaluated with possibility of TB, malignancy or vasculitis. Fibreoptic bronchoscopy was done that showed a ‘stony cave’ trachea. Histopathology confirmed the dia gnosis to be ‘Tracheobronchopathia osteochondroplastica (TO)’. He was treated with antibiotics for his infection with total resolution of chest sahdows. He is managed conservatively for his TO. Key messageTracheobronchopathia osteochondroplastica (TO) is a disorder caused by the accumu...
Source: Respirology Case Reports - July 11, 2023 Category: Respiratory Medicine Authors: Asmita A. Mehta, Aditya Ashok, Nithya Haridas, Akhilesh Kunoor, Jyotsana Yesodharan Tags: CLINICAL IMAGE Source Type: research