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Assessing the Sealing Performance and Clinical Outcomes of Endodontic Treatment in Patients with Chronic Apical Periodontitis Using Epoxy Resin and Calcium Salicylate Seals
Conclusions: The in vitro study showed that Adseal had a better sealing capacity and a lower degree of dye penetration compared to Sealapex. However, on clinical evaluation in the in vivo study, both patient groups exhibited significant improvements in periapical index, tooth mobility scores, and pain reduction following endodontic treatment. Nevertheless, patients treated with Adseal showed a significantly greater improvement in PAI values, tooth mobility, and teeth healing after treatment. Overall, Adseal, as an endodontic sealer, may provide better sealing capabilities and enhanced clinical outcomes in the treatment of ...
Source: Medicina (Kaunas) - June 28, 2023 Category: Universities & Medical Training Authors: Razvan Mihai Horhat Bogdan Andrei Bumbu Laura Orel Oana Velea-Barta Laura Cirligeriu Gratiana Nicoleta Chicin Marius Pricop Mircea Rivis Stefania Dinu Delia Ioana Horhat Felix Bratosin Roxana Manuela Fericean Rodica Anamaria Negrean Luminita Maria Nica Source Type: research
Future targets for migraine treatment beyond CGRP
ConclusionWhile current research on these non-CGRP drug targets has not yet led to the development of efficacious therapies, human provocation studies using these targets have provided valuable insight into underlying mechanisms of migraine headaches and auras. Further studies are needed on these alternative therapies in non-responders of CGRP(-receptor) targeted therapies with the ultimate aim to pave the way towards a headache-free future for all migraine patients.
Source: The Journal of Headache and Pain - June 28, 2023 Category: Neurology Source Type: research
