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Total 5328 results found since Jan 2013.

Sub-chondroplasty Reduces Pain, Improves Function and Delays the Conversion to Arthroplasty in Patients with Advanced Knee Osteoarthritis: A Stratified Meta-analysis and Quality Assessment
J Surg Orthop Adv. 2023 Summer;32(2):65-74.ABSTRACTThere is an ongoing interest in alternatives to total knee arthroplasty, as a means to delay inevitable replacement. A possible, minimally invasive, alternative is a sub-chondroplasty, involving interosseous injection of bone substitute materials such as calcium phosphate (CaPo4), platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC) or Injectable demineralized bone matrix (iDBM) into the subchondral bone. Eleven clinical trials were found, investigating the effectiveness of sub-chondroplasties performed using CaPo4, PRP, BMAC, and iDBM. A non-stratified and ...
Source: Journal of surgical orthopaedic advances - September 5, 2023 Category: Orthopaedics Authors: Mariana Roldan Mohamed E Awad Trey D VanAken Wael Saasouh Padmavathi Patel Gamal Mostafa Khaled J Saleh Source Type: research

Acute calcific periarthritis of acromioclavicular joint: A  case report
We report a case of a 55-year-old otherwise healthy man, presented with acute onset of pain and restriction of movement of left shoulder, who was diagnosed based on radiographic findings with calcific periarthritis of the acromioclavicular joint. As suggested by the literatures, he was managed conservatively, and no reoccurrence was reported after the episode.
Source: Clinical Case Reports - September 5, 2023 Category: General Medicine Authors: Shila Awal, Nabaraj Acharya, Lila Awal, Nabin Prajapati, Kunal Gupta, Ayushi Srivastava Tags: CASE REPORT Source Type: research

Dietary Zinc Deficiency Induces Ca < sub > v < /sub > 3.2-Dependent Nociceptive Hypersensitivity in Mice
Biol Pharm Bull. 2023;46(9):1343-1346. doi: 10.1248/bpb.b23-00270.ABSTRACTCav3.2 channels belong to the T-type calcium channel (T-channel) family, i.e., low voltage-activated calcium channels, and are abundantly expressed in the nociceptors, playing a principal role in the development of pathological pain. The channel activity of Cav3.2 is suppressed by zinc under physiological conditions. We thus tested whether dietary zinc deficiency would cause Cav3.2-dependent nociceptive hypersensitivity in mice. In the mice fed with zinc deficient diet for 2 weeks, plasma zinc levels declined by more than half, and mechanical allodyn...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Shiori Tomita Fumiko Sekiguchi Maho Tsubota Atsufumi Kawabata Source Type: research

Glutamatergic Neurons in the Zona Incerta Modulate Pain and Itch Behaviors in Mice
AbstractEmerging evidence suggest that parvalbumin neurons in zona incerta (ZI) modulate pain and itch behavior in opposite manners. However, the role of ZI glutamatergic neurons, a unique incertal neuronal subpopulation residing in the caudal division, in pain and itch modulation remains unknown. In the present study, by combining chemogenetic manipulation, fiber photometry, and behavioral tests, we proved that incertal glutamatergic neurons served as an endogenous negative diencephalic modulator for both pain and itch processing. We demonstrated that ZI vesicular glutamate transporter 2 (VGluT2) neurons exhibited increas...
Source: Molecular Neurobiology - September 1, 2023 Category: Neurology Source Type: research

Multiple brown tumors: a bone complication due to long-term untreated pseudohypoparathyroidism
We describe the case of a 33-year-old woman, referred for the diagnostic evaluation of lytic bone lesions of the lower limbs, in the context of asymptomatic pseudohypoparathyroidism. She had been treated with alfacalcidol and calcium during her childhood. Treatment was discontinued at the age of 18 years old because of the lack of symptoms. A femur biopsy revealed a lesion rich in giant cells, without malignancy, consistent with a brown tumor. Laboratory tests showed a parathyroid level at 1387 pg/ml (14 –50). Whole-body Fluorocholine PET/CT revealed hypermetabolism of bone lesions. The final diagnosis was brown tumors r...
Source: Osteoporosis International - August 29, 2023 Category: Orthopaedics Source Type: research

Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species
CONCLUSION: The results suggest that ELP may predispose to chronic "pain" and compulsive psychopathology in part mediated by alterations of sphingolipid metabolism, which have been previously described in the context of addiction and psychiatric diseases.PMID:37635256 | DOI:10.1186/s13578-023-01106-3
Source: Cancer Control - August 27, 2023 Category: Cancer & Oncology Authors: Alexandra Vogel Timo Ueberbach Annett Wilken-Schmitz Lisa Hahnefeld Luisa Franck Marc-Philipp Weyer Tassilo Jungenitz Tobias Schmid Giulia Buchmann Florian Freudenberg Ralf P Brandes Robert Gurke Stephan W Schwarzacher Gerd Geisslinger Thomas Mittmann Irm Source Type: research

Unlocking new approaches to Urolithiasis management via Nutraceutical
Curr Pharm Biotechnol. 2023 Aug 21. doi: 10.2174/1389201024666230821122416. Online ahead of print.ABSTRACTUrolithiasis, commonly known as kidney stones, is characterized by the formation of hard deposits in the urinary tract. These stones can cause severe pain and discomfort, and their management typically involves a combination of medical interventions and lifestyle modifications. According to the literature, 30% and 50% of urolithiasis cases recur. Between 9 and 12% of persons in industrialised countries are predicted to have urolithiasis at some time. Due to the high frequency of stone formation, recurrent nature, and p...
Source: Current Pharmaceutical Biotechnology - August 23, 2023 Category: Biotechnology Authors: Ravindra Pal Singh Anurag Mishra Shailendra Singh Chandel Mohit Agarwal Himmat Singh Chawra Mithilesh Singh Gaurav Dubey Source Type: research

Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis
Acta Derm Venereol. 2023 Aug 22;103:adv13382. doi: 10.2340/actadv.v103.13382.ABSTRACTCrisaborole, a phosphodiesterase 4 (PDE4) inhibitor, has been approved for the treatment of mild to moderate atopic dermatitis. Atopic dermatitis is often associated with increased pain. Using a mouse model, this study investigated whether crisaborole suppresses pain associated with atopic dermatitis and the potential mechanisms underlying it. The mouse model for atopic dermatitis was developed by repeatedly applying MC903. MC903-treated mice had increased spontaneous scratching (itch-related behaviour) and wiping behaviour (pain-related b...
Source: Acta Derm Venereol A... - August 22, 2023 Category: Dermatology Authors: Darya Pavlenko Zeynep Todurga Seven Lauren Bystrom Anika Markan Rebecca Verpile Hirotake Ishida Tasuku Akiyama Source Type: research