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Nutrition: Calcium
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Total 5328 results found since Jan 2013.
Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular Senescence
Int J Mol Sci. 2023 Aug 2;24(15):12343. doi: 10.3390/ijms241512343.ABSTRACTOsteoarthritis (OA) is a chronic joint disease characterized by articular cartilage calcification, loss of articular cartilage, bone changes, pain, and disability. Cartilage calcification is one hallmark of OA and is predominantly caused by basic calcium crystals formed due to an imbalance of the pyrophosphate pathway. Sortilin is a transmembrane protein that contributes to vascular calcification in atherosclerosis by externalizing alkaline phosphatase (ALP)-containing vesicles. Calcification in atherosclerosis and osteoarthritis has been associated...
Source: Atherosclerosis - August 12, 2023 Category: Cardiology Authors: Elisabeth Richter Christoph H Lohmann Francesco Dell'Accio Claudia Goettsch Jessica Bertrand Source Type: research
Structure activity relationships of 5-HT < sub > 2B < /sub > and 5-HT < sub > 2C < /sub > serotonin receptor antagonists: N < sup > 6 < /sup > , C2 and 5'-Modified (N)-methanocarba-adenosine derivatives
Eur J Med Chem. 2023 Jul 31;259:115691. doi: 10.1016/j.ejmech.2023.115691. Online ahead of print.ABSTRACT(N)-Methanocarba adenosine derivatives were structurally modified to target 5-HT2B serotonin receptors as antagonists, predominantly containing branched N6-alkyl groups. N6-Dicycloalkyl-methyl groups, including their asymmetric variations, as well as 2-iodo, were found to generally favor 5-HT2Rs, while only N6-dicyclohexyl-methyl derivative 35 showed weak 5-HT2AR affinity (Ki 3.6 μM). The highest 5-HT2BR affinities were Ki 11-23 nM (N6-dicyclopropyl-methyl-2-iodo 11, 2-chloro-5'-deoxy-5'-methylthio 15 and N6-((R)-cyclo...
Source: European Journal of Medicinal Chemistry - August 10, 2023 Category: Chemistry Authors: Dilip K Tosh Maggie M Calkins Marko S Ivancich Hailey A Bock Ryan G Campbell Sarah A Lewicki Eric Chen Zhan-Guo Gao John D McCorvy Kenneth A Jacobson Source Type: research
The Invisible Cause of Inflammation
A patient came to me with a surprising problem…
This patient was suffering from a lack of energy. He had trouble concentrating during the day. He’d lost his appetite and was in a kind of general malaise.
He’d gone to two other doctors who sent him to a lab for tests…and he brought his lab reports with him.
He had no other symptoms except his blood pressure was a bit high. Right away, the doctor who looked at the report put him on a blood pressure pill.
But he didn’t feel better.
I told him that we were going to stop the medication and test for a suspicion I had. So we measured his heavy metals.
We found t...
Source: Al Sears, MD Natural Remedies - August 9, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Source Type: news
Giant parathyroid adenoma causing severe hypercalcemia; a case report from Duhok
CONCLUSION: Recurrent nephrolithiasis requires more thorough investigation for the possible underlying cause. Primary hyperparathyroidism due to parathyroid adenoma can present with recurrent renal stones and some vague symptoms.PMID:37554877 | PMC:PMC10406081 | DOI:10.1097/MS9.0000000000001005
Source: Annals of Medicine - August 9, 2023 Category: Internal Medicine Authors: Dildar Haji Musa Azri Salih Haji Sgery Asaad Shareef Omar Gina James Keorges Nashwan Mr Ibrahim Source Type: research
Cold Hands or Feet: Is It Raynaud's or Not?
Med Clin North Am. 2023 Sep;107(5):829-844. doi: 10.1016/j.mcna.2023.04.005. Epub 2023 Jun 4.ABSTRACTRaynaud's phenomenon is an exaggerated response to cold stimuli that may be primary or secondary. The diagnosis relies on patient history and physical examination to distinguish RP from other vasomotor dysfunction (e.g. acrocyanosis, pernio, small fiber neuropathy with vasomotor symptoms, and complex regional pain syndrome). Achenbach syndrome, or spontaneous venous hemorrhage, may also be mistaken for RP but is a self-limiting phenomenon. Laboratory evaluation and vascular diagnostic testing may identify SRP causes. Regard...
Source: The Medical Clinics of North America - August 4, 2023 Category: General Medicine Authors: Daniella Kadian-Dodov Source Type: research
Evaluation of the clinical and radiographic effectiveness of treating peri-implant bone defects with a new biphasic calcium phosphate bone graft: a prospective, multicenter randomized controlled trial
CONCLUSION: The GBR procedure with the newly developed BCP showed favorable clinical, radiographic, postoperative discomfort-related, and early wound healing outcomes for peri-implant dehiscence defects that were similar to those for DBBM.TRIAL REGISTRATION: Clinical Research Information Service Identifier: KCT0006428.PMID:37524378 | DOI:10.5051/jpis.2300640032
Source: Journal of Periodontal and Implant Science - July 31, 2023 Category: Dentistry Authors: Jae-Hong Lee Hyun-Wook An Jae-Seung Im Woo-Joo Kim Dong-Won Lee Jeong-Ho Yun Source Type: research
