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Total 442 results found since Jan 2013.

Targeting Biological Polyanions in Blood: Strategies towards the Design of Therapeutics.
Abstract In this review, we highlight well-described and emerging polyanions, and the way these molecules can be targeted in the design of potential therapeutics (synthetic and biologics) with applications in thrombosis and hemostasis. It is important to strike a balance between bleeding and clotting. In thrombosis, unwanted blood clots are formed in the lumen of a blood vessel, obstructing the flow of blood through the circulatory system. Over many years of research, several polyanionic biopolymers that can either impede (anticoagulant) or promote (procoagulant) blood clotting have been identified. Mediators impe...
Source: Biomacromolecules - June 3, 2020 Category: Biochemistry Authors: La CC, Takeuchi LE, Abbina S, Vappala S, Abbasi U, Kizhakkedathu JN Tags: Biomacromolecules Source Type: research

Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective
AbstractIn recent years, there was an abrupt increase in the incidence of renal tumors, which prompt up the appearance of cutting ‐edge technology, including minimally invasive and organ‐preserving approaches, such as laparoscopic partial nephrectomy (LPN). LPN is an innovative technique used to treat small renal masses that have been gaining popularity in the last few decades due to its promissory results. However, the bl eeding control remains the main challenge since the majority of currently available hemostatic agents (HAs) used in other surgical specialities are inefficient in LPN. This hurried the search for eff...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 25, 2020 Category: Materials Science Authors: Margarida Pacheco, Alexandre A. Barros, Ivo M. Aroso, Riccardo Autorino, Est êvão Lima, Joana M. Silva, Rui L. Reis Tags: REVIEW ARTICLE Source Type: research

Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective.
Abstract In recent years, there was an abrupt increase in the incidence of renal tumors, which prompt up the appearance of cutting-edge technology, including minimally invasive and organ-preserving approaches, such as laparoscopic partial nephrectomy (LPN). LPN is an innovative technique used to treat small renal masses that have been gaining popularity in the last few decades due to its promissory results. However, the bleeding control remains the main challenge since the majority of currently available hemostatic agents (HAs) used in other surgical specialities are inefficient in LPN. This hurried the search for...
Source: Biomed Res - May 25, 2020 Category: Research Authors: Pacheco M, Barros AA, Aroso IM, Autorino R, Lima E, Silva JM, Reis RL Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Efficient antibacterial dextran-montmorillonite composite sponge for rapid hemostasis with wound healing.
Abstract Montmorillonite (MMT) powder, as the most effective hemostats in natural silicates, is restricted for commercial application due to its embolic effect. Until now, it's still a challenge to control the leakage of MMT and avoid its side-effects. Herein, poly aldehyde dextran (PDA)/MMT composite sponge (PM) with commendable tissue adhesion, antibacterial, and wound healing performances is developed for massive hemorrhage control. Based on the high degree of perfect synergism of PDA and MMT, the PM sponge can rapidly seal the wound, and promote cells aggregation and adhesion, whole coagulation system activati...
Source: International Journal of Biological Macromolecules - May 20, 2020 Category: Biochemistry Authors: Liu C, Liu C, Yu S, Wang N, Yao W, Liu X, Sun G, Song Q, Qiao W Tags: Int J Biol Macromol Source Type: research

Rational design of porous starch/hyaluronic acid composites for hemostasis.
Abstract Effective hemorrhage control is pivotal for decreasing the trauma death both in civilian and military but has proven to be dauntingly challenging, especially for solid viscera and artery trauma. Here we report the fabrication of a novel starch-based hemostat, sodium trimethaphosphate (STMP)-crosslinked starch/hyaluronic acid (HA) (ScSH) porous composites. Aiming at hemostatic potential, physicochemical properties, cytocompatibility, hemocompatibility, histocompatibility and hemostatic performance of ScSH composites have been studied. As it turned out, the incorporation of HA greatly improved the water abs...
Source: International Journal of Biological Macromolecules - May 5, 2020 Category: Biochemistry Authors: Wang Y, Liu G, Wu L, Qu H, Song D, Huang H, Wu C, Xu M Tags: Int J Biol Macromol Source Type: research

Thermal Treatment Stimulus on Erythrocyte Compatibility and Hemostatic Behaviour of One-Dimensional Bioactive Nano-Structures.
This study identifies the role and significance of heat treatment parameters on blood compatibility and hemostatic performances. Bioactive nanomaterials step-annealed at 550 °C and 600 °C enhances the biocompatibility due to the liberation of nitrate content. This also develops the anisotropic structures such as needle-like and rod-like appearances that positively improve the erythrocyte compatibility. Different stable crystalline phases such as NaCaPO4 , Na2 Ca2 Si3 O9 and Na1.8 Ca1.1 Si6 O14 were observed for all the bioactive materials, while in the case of 800 °C phase transition of Na3 CaPSiO7 was perceived along w...
Source: Biomed Res - May 2, 2020 Category: Research Authors: Chitra S, Bargavi P, Chandran RR, Balakumar S Tags: J Biomed Mater Res A Source Type: research

Cover Image
On the Cover: Right ankle, anterolateral viewing portal, patient supine under dry conditions: chondral plugs are introduced with a hemostat through the anteromedial portal with the foot maintained in plantarflexion using an ankle distractor. Plugs are placed from posterior to anterior into the defect on the superior aspect of the autograft bone. View the accompanying video and see the related article at www.arthroscopytechniques.org. Courtesy of Laura Luick, M.D., Garrett Steinmetz, M.D., and Amgad Haleem, M.D., Ph.D.
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - April 30, 2020 Category: Surgery Source Type: research

Anti-infective and wound-healing pleiotropic actions of Ankaferd hemostat.
Authors: Haznedaroğlu IC, Çelebier M Abstract no needed for the letter to the editor. PMID: 32305048 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - April 21, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Efficacy of a novel self-assembling peptide hemostatic gel as rescue therapy for refractory acute gastrointestinal bleeding
Conclusions PuraStat is feasible, safe, and effective in controlling different types of gastrointestinal hemorrhage after failure of conventional hemostatic methods. Its application also does not hinder continuing endotherapy. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Endoscopy - April 20, 2020 Category: Gastroenterology Authors: de Nucci, Germana Reati, Raffaella Arena, Ilaria Bezzio, Cristina Devani, Massimo Corte, Cristina della Morganti, Daniela Mandelli, Enzo Domenico Omazzi, Barbara Redaelli, Davide Saibeni, Simone Dinelli, Marco Manes, Gianpiero Tags: Original article Source Type: research

Ankaferd hemostat: from molecules to medicine.
ANKAFERD HEMOSTAT: FROM MOLECULES TO MEDICINE. Turk J Med Sci. 2020 Apr 14;: Authors: Çiftçiler R, Haznedaroglu IC Abstract Ankaferd hemostat (ABS; Ankaferd blood stopper®, Istanbul, Turkey) is a hemostatic agent having an impact on red blood cell-fibrinogen interactions. The hemostatic effect of ABS depends upon the quick promotion of a protein network, particularly fibrinogen gamma, in relation to the erythrocyte aggregation. The entire physiological process involves ABS-induced formation of the protein network by vital erythrocyte aggregation. Vital erythroid aggregation occurs with the spectrine...
Source: Turkish Journal of Medical Sciences - April 15, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Non-antibiotic prophylaxis in thyroid surgery. Experience of a single Institution and revision of literature.
CONCLUSIONS: Fever, neutrophilic leukocytosis and increased PCR cannot be assessed as predictive factors of infectious complication in thyroid surgery. The cutaneous antisepsis of the operative field with chlorhexidine gluconate, the improvement of the surgical technique, the protection of the cutaneous margins of incision, the use of new devices, the accurate hemostasis and the reduction of surgery time lead to a lack of SSIs and systemic infection complications in all patients undergoing thyroid surgery in NO-AP. KEY WORDS: Antibiotic prophylaxis, Surgical site infections, Thyroid surgery, Thyroidectomy. PMID: 32...
Source: Annali Italiani di Chirurgia - April 13, 2020 Category: Surgery Tags: Ann Ital Chir Source Type: research

In-vitro and in-vivo evaluation of modified sodium starch glycolate for exploring its haemostatic potential
Publication date: Available online 11 February 2020Source: Carbohydrate PolymersAuthor(s): Vineeta Panwar, Jijo Thomas, Anjana Sharma, Vianni Chopra, Swati Kaushik, Ashutosh Kumar, Deepa GhoshAbstractThe control of blood flow from breached blood vessels during surgery or trauma is challenging. With the existing treatment options being either expensive or ineffective, the development of a haemostat that overcome such drawbacks would be beneficial. With an aim to develop an ideal haemostat, the potential of sodium starch glycolate (SSG), a commonly used pharmaceutical disintegrant was modified to obtain porous microparticles...
Source: Carbohydrate Polymers - February 13, 2020 Category: Biomedical Science Source Type: research

A Comparative Efficacy Evaluation of Recombinant Topical Thrombin (RECOTHROM ®) With A Gelatin Sponge Carrier Versus Topical Oxidized Regenerated Cellulose (TABOTAMP®/SURGICEL®) In A Porcine Liver Bleeding Model.
Conclusions: In this model, rT plus gelatin sponge carrier (active) was a more effective hemostat than ORC (passive) in both heparinized and non-heparinized animals. PMID: 31955627 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - January 22, 2020 Category: Surgery Tags: J Invest Surg Source Type: research

Comparison of acid and water-soluble chitosan doped fibrous cellulose hemostat wet laid nonwoven web for hemorrhage application.
Abstract Fibrous hemostat was produced using wet laying technique comprising of acid and water soluble chitosan with fibrous cellulose. The hemostatic efficiency and their structural properties were evaluated using blood clotting time, whole blood adhesion and analytical characterization techniques. The maximum concentration of chitosan utilised for the production of nonwoven was 1.5 w/v % upon which increased the viscosity of the solution. The absorption of phosphate buffer solution was found to be 1117% for acid soluble chitosan based nonwoven whereas for water soluble chitosan based nonwoven was 997%. Increase...
Source: International Journal of Biological Macromolecules - January 14, 2020 Category: Biochemistry Authors: Hemamalini T, Vikash N, Brindha P, Abinaya M, Dev VRG Tags: Int J Biol Macromol Source Type: research

Puff Pastry-Like Chitosan/Konjac Glucomannan Matrix with Thrombin-Occupied Microporous Starch Particles as a Composite for Hemostasis
In this study, we produced a puff pastry-like chitosan/konjac glucomannan matrix loaded with thrombin-occupied microporous starch particles to initiate hemostasis. The composite showed a hierarchical porous structure system consisting of porous and rough structures with evenly distributed microporous starch particles. Thrombin was evenly and independently distributed on the microporous starch particles within the hierarchical system and served to accelerate hemostasis. Meanwhile, the composite displayed excellent water absorption capacity, high zeta potential, roughness, and porosity. The composite was found to elicit desi...
Source: Carbohydrate Polymers - January 8, 2020 Category: Biomedical Science Source Type: research