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Total 442 results found since Jan 2013.

Fabrication of porous starch microspheres by electrostatic spray and supercritical CO2 and its hemostatic performance.
Abstract Effective control of bleeding is critical to saving lives whether on the battle field or in civilian life. Microporous starch (MS) is a promising hemostat for its extensive sources, huge surface area and good biocompatibility. However, the hemostatic performance of MS is limited because of its complex preparation process and lack of effective component to activate coagulation factors. Herein, porous starch microspheres modified by calcium (Ca-PSM) with dense shell and honeycomb micro-porous core were prepared by electrostatic spray and supercritical CO2 for the first time. The topological morphology of Ca...
Source: International Journal of Biological Macromolecules - November 4, 2018 Category: Biochemistry Authors: Chen J, Chen S, Cheng W, Lin J, Hou S, Liu H, Chen Q Tags: Int J Biol Macromol Source Type: research

Experimental Evaluation of a New Tissue Factor-Based Topical Hemostat (TT-173) for Treatment of Hepatic Bleeding.
CONCLUSIONS: TT-173 shows favorable pharmacodynamic properties for improving hemostasis in partial liver resection which support further investigation of the product in this surgical indication. PMID: 30380352 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - November 2, 2018 Category: Surgery Tags: J Invest Surg Source Type: research

BARDA adds $26m to Stratatech ’ s StrataGraft development deal
Mallinckrodt‘s (NYSE: MNK) Stratatech has won an additional $26 million in Project BioShield funding from the the U.S. Biomedical Advanced Research and Development Authority to support pediatric studies of its StrataGraft engineered skin tissue. The funding will support continued development of the StrataGraft as a potential medical countermeasure for large-scale burn incidents, U.K.-based Mallinckrodt said. BARDA previously supplied funding to Stratatech during its Phase 3 trial of the Stratagraft in adults, which explored the safety and efficacy of the device in promoting autologous skin regeneration of complex ...
Source: Mass Device - October 17, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Featured Regenerative Medicine Wound Care Mallinckrodt Stratatech Corp. Source Type: news

FDA permits marketing of new endoscopic device for treating gastrointestinal bleeding
The U.S. Food and Drug Administration permitted marketing of Hemospray, a new device used to help control certain types of bleeding in the gastrointestinal (GI) tract.“The device provides an additional, non-surgical option for treating upper and lower GI bleeding in certain patients, and may help reduce the risk of death from a GI bleed for many patients,” said Binita Ashar, M.D., director, division of surgical devices, in the FDA’s Center for Devices and R adiological Health.GI bleeding can occur in the upper GI tract (esophagus, stomach or small intestine) or the lower GI tract (colon and rectum). Causes of GI blee...
Source: Medical Hemostat - September 23, 2018 Category: Medical Devices Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

GRGDS-functionalized chitosan nanoparticles as a potential intravenous hemostat for traumatic hemorrhage control in an animal model
Publication date: Available online 5 September 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Pingyi Zhang, Subo Li, Shikun Zhang, Xue Zhang, Luming Wan, Zhimin Yun, Shouping Ji, Feng Gong, Manna Huang, Leilei Wang, Xinhai Zhu, Yingxia Tan, Yiqian WanAbstractHemostats, which are used for immediate intervention during internal hemorrhage in order to reduce resulting mortality and morbidity, are relatively rare. Here, we describe novel intravenous nanoparticles (CPG-NPs-2000) with chitosan succinate (CSS) as cores, polyethylene glycol (PEG-2000) as spacers and a glycine-arginine-glycine-aspartic aci...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - September 5, 2018 Category: Nanotechnology Source Type: research

Cost-consequence analysis of a hemostatic matrix (FLOSEAL) alone or in combination for spine surgery patients.
CONCLUSIONS: The use of F versus F+G/T could lead to annual cost savings for US hospitals performing a low- to high-volume of spinal surgeries per year. PMID: 30112922 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - August 17, 2018 Category: Health Management Tags: J Med Econ Source Type: research

In-vitro and in-vivo evaluation of hemostatic potential of decellularized ECM hydrogels
Publication date: Available online 6 August 2018Source: Materials LettersAuthor(s): Reiza D. Ventura, Andrew R. Padalhin, Byong Taek LeeAbstractExtracellular matrix (ECM) hydrogels with a porous microstructure and good swelling behavior were fabricated via lyophilization and cross-linked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC). Platelet adhesion studies revealed that platelets easily adhered to hydrogels while coagulation studies showed rapid blood aggregate formation. In-vitro cytotoxicity studies showed ECM hydrogels are biocompatible. In-vivo studies using rat tail bleeding and rabbit arterial injury ...
Source: Materials Letters - August 7, 2018 Category: Materials Science Source Type: research

An Injectable Hemostat Composed of a Polyphosphate-Conjugated Hyaluronan Hydrogel.
Abstract We have developed a new hydrogel hemostat composed of hyaluronan (HA) conjugated with inorganic polyphosphate (PolyP). A hemostatic hydrogel, HAX-PolyP, was formed rapidly by mixing aldehyde-modified HA and hydrazide-modified HA conjugated with PolyP (HA-PolyP). Although the gelation rate decreased with increasing PolyP content, the gelation time was below 5 min. In addition, the hydrogel swelling volume decreased with increasing PolyP content, but the degradation rate did not depend on PolyP content and the hydrogel underwent complete degradation through hydrolysis over 3 weeks in phosphate buffered sali...
Source: Biomacromolecules - July 9, 2018 Category: Biochemistry Authors: Sakoda M, Kaneko M, Ohta S, Qi P, Ichimura S, Yatomi Y, Ito T Tags: Biomacromolecules Source Type: research

Gel-E wins FDA OTC nod for gel-e Flex flowable hemostat
Early stage wound care company Gel-e said today it won FDA 510(k) clearance for its gel-e Flex as an over-the-counter flowable hemostat. The College Park, Md.-based company said the clearance expands the labeling for the local management of lacerations and minor bleeding, and said the products were specifically designed to be usable by both trained professionals and patients. “This clearance is the next step in expanding our OTC product line, and will be a key component of gel-e’s 21st Century First Aid Kit. We are continuing to develop a tool kit that will provide the best possible options for all manner of...
Source: Mass Device - June 29, 2018 Category: Medical Devices Authors: Fink Densford Tags: 510(k) Food & Drug Administration (FDA) Regulatory/Compliance Wound Care gel-e Source Type: news

Porous electrospun starch rich polycaprolactone blend nanofibers for severe hemorrhage.
Abstract Starch nanofiber based hemostat was prepared by electrospinning process for biomedical applications. Bead free uniform starch nanofiber along with polycaprolactone polymer was produced using new solvent combination. The swelling of the PCL/starch mat was 240% higher compared to pristine PCL mat. The blood clotting time of the developed PCL/starch mat was 156 s and the contact angle was 30.8°. The results suggest that the developed nanofibers exhibited good hemostatic potential with quick rate of clotting to control blood loss in traumatic injuries. PMID: 29964114 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - June 29, 2018 Category: Biochemistry Authors: Giri Dev VR, Hemamalini T Tags: Int J Biol Macromol Source Type: research

Combination treatment for cicatrix after neonatal circumcision: an office-based solution to a challenging problem
We present our successful experience that combines cicatrix stretching with a hemostat using local anesthesia in the office followed by several weeks of topical steroids with a minority of patients needing any additional therapy.
Source: Journal of Pediatric Urology - June 27, 2018 Category: Urology & Nephrology Authors: Seth A. Alpert, Christina B. Ching, Daniel G. DaJusta, Daryl J. McLeod, Molly E. Fuchs, Venkata R. Jayanthi Source Type: research

CleanCision Wins Readers ’ Choice Award in MDEA Competition
There was much pomp and circumstance at the Medical Design Excellence Awards Tuesday as the best technologies were honored at the Jacob K. Javits Convention Center in New York. For one technology, however, it was a strong call of validation. CleanCision, earned the overall Reader’s Choice Award, which spans all categories in the competition. The active cleansing technology also earned the 2018 Medical Device Excellence Award Bronze Medal in the ER and OR Tools Category. CleanCision was developed by San Carlos, CA-based Prescient Medical. “We’re thrilled and we’re honored for validation of what we’re doing,” Jer...
Source: MDDI - June 13, 2018 Category: Medical Devices Authors: Omar Ford Tags: Design Source Type: news

Nailed It!
​What do you do for a nail from a nail gun in the hand? This procedure is simple, but you have to worry about the aftermath. Complicated issues may arise post-procedure in the days to weeks after extraction, including retained foreign bodies, infection, fractures, disability, pain, nerve damage, tendon rupture, and cosmetic concerns.​Removing the nail is only half the battle. Proper removal, treatment, and follow-up should be considered with all foreign bodies in the skin, especially the hand. Being prepared for the possible aftershocks will help your patient have a successful recovery.A 23-year-old man with a nail fro...
Source: The Procedural Pause - June 1, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

Sa1962 THE HEMOSTATIC EFFECT OF MUSSEL-INSPIRED CATECHOL ADHESIVE SHEET AFTER MUCOSECTOMY INDUCED ULCER: PORCINE EXPERIMENT
Gastrointestinal bleeding is the common problem in daily clinical practice. InnoSEAL Plus ® is a sheet-type hemostat that is made of a mussel-inspired catecholic adhesive material. It can stop a variety of bleedings in a coagulopathy independent manner. The aim of this study was to evaluate hemostatic efficacy of the catechol-adhesive sheet on gastric ulcer bleeding on porcine model.
Source: Gastrointestinal Endoscopy - May 30, 2018 Category: Gastroenterology Authors: In Kyung Yoo, Joo Young Cho, Sung-Pyo Hong Tags: Saturday abstract Source Type: research

Cook Medical loses Houston-based IVC suit, plans to appeal
Cook Medical said today it lost a suit related to its Celect vena cava filters in Houston, but that it plans to appeal the decision. The ruling came from a jury in Houston, which ruled in favor of a plaintiff, though the Bloomington, Ind.-based company did not release any detailed information related to the case. “We are dedicated to providing life-saving treatment options for patients and will continue to defend all of our IVC filters. Our filters have saved thousands of lives, are clinically successful and are critical to patient well-being,” Cook Medical vascular division VP Mark Breedlove said in a prep...
Source: Mass Device - May 25, 2018 Category: Medical Devices Authors: Fink Densford Tags: Legal News Vascular Cook Medical Source Type: news