Thermal Treatment Stimulus on Erythrocyte Compatibility and Hemostatic Behaviour of One-Dimensional Bioactive Nano-Structures.

This study identifies the role and significance of heat treatment parameters on blood compatibility and hemostatic performances. Bioactive nanomaterials step-annealed at 550 °C and 600 °C enhances the biocompatibility due to the liberation of nitrate content. This also develops the anisotropic structures such as needle-like and rod-like appearances that positively improve the erythrocyte compatibility. Different stable crystalline phases such as NaCaPO4 , Na2 Ca2 Si3 O9 and Na1.8 Ca1.1 Si6 O14 were observed for all the bioactive materials, while in the case of 800 °C phase transition of Na3 CaPSiO7 was perceived along with P2 O5 . Alternatively, morphology varied from cubical (600 °C) to rod-like (step annealing) and further turned towards flake-like (800 °C) structures. Step-annealing process decomposed the nitrate groups as well as maintained the glass network without altering the crystalline phases. As a result, bioactive nanomaterials subjected to step-annealing at 550 °C along with 600 °C exhibited superior compatibility with erythrocytes. Bioglass heat treated at 800 °C revealed incredible blood clotting efficacy, in which Ca2+ ions initiated the thrombotic effect, blood components were concentrated due to the effect of calcium and enhances the hemostatic performance. Bioactive glass annealed below 800 °C facilitates the bio-compatibility, subsequently encourage bone ingrowths at in-vivo. Bioglass-800 °C inspired the fibrin formation and induced clot as a hemo...
Source: Biomed Res - Category: Research Authors: Tags: J Biomed Mater Res A Source Type: research