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Therapy: Stem Cell Therapy
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CDC42-mediated Wnt signaling facilitates odontogenic differentiation of DPCs during tooth root elongation
CONCLUSIONS: We innovatively revealed that CDC42 was responsible for guiding root elongation in a mesenchyme-specific manner. Furthermore, CDC42-mediated canonical Wnt signaling regulated odontogenic differentiation of DPCs during root formation.PMID:37726858 | PMC:PMC10510226 | DOI:10.1186/s13287-023-03486-2
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Tao Zhou Guoqing Chen Yuchan Xu Shuning Zhang Huilin Tang Tao Qiu Weihua Guo Source Type: research
Heterogeneity in RAG 1/2 Deficiency: 35 Cases From A Single Center
This study aimed to define the clinical/laboratory spectrum of RAG1/2 deficiency. We retrospectively reviewed the clinical/laboratory data of 35 patients, grouped them as severe combined immunodeficiency (SCID), Omenn Syndrome (OS), and delayed-onset combined immunodeficiency (CID) and reported nine novel mutations. Male/female ratio was 23/12. Median age of clinical manifestations was 1 months (mo) (0.5-2), 2 mo (1.25-5), and 14 mo (3.63-27), age at diagnosis was 4 mo (3-6), 4.5 mo (2.5-9.75), and 27 mo (14.5-70) in SCID (n=25;71.4%), OS (n=5;14.3%), and CID (n=5;14.3%) patients, respectively. Common clinical manifestatio...
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Betul Karaatmaca Deniz Cagdas Saliha Esenboga Baran Erman Cagman Tan Tuba Turul Ozgur Kaan Boztug Mirjam Van Der Burg Ozden Sanal Ilhan Tezcan Source Type: research
The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research
Mesenchymal Stem Cell-Derived Exosomes Mitigate Acute Murine Liver Injury via Ets-1 and Heme Oxygenase-1 Up-regulation
CONCLUSION: Exosome therapy activates the JNK signaling activation pathway as well as up-regulates Ets-1 and HO-1 expression, thereby protecting hepatocytes against hepatotoxin-induced cell death.PMID:37723631 | DOI:10.2174/1574888X19666230918102826
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Ying-Hsien Kao Chih-Yang Chang Yu-Chun Lin Po-Han Chen Po-Huang Lee Huoy-Rou Chang Wen-Yu Chang Yo-Chen Chang Shen-Fa Wun Cheuk-Kwan Sun Source Type: research
The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research
Mesenchymal Stem Cell-Derived Exosomes Mitigate Acute Murine Liver Injury via Ets-1 and Heme Oxygenase-1 Up-regulation
CONCLUSION: Exosome therapy activates the JNK signaling activation pathway as well as up-regulates Ets-1 and HO-1 expression, thereby protecting hepatocytes against hepatotoxin-induced cell death.PMID:37723631 | DOI:10.2174/1574888X19666230918102826
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Ying-Hsien Kao Chih-Yang Chang Yu-Chun Lin Po-Han Chen Po-Huang Lee Huoy-Rou Chang Wen-Yu Chang Yo-Chen Chang Shen-Fa Wun Cheuk-Kwan Sun Source Type: research
The Warburg effect on radioresistance: Survival beyond growth
Biochim Biophys Acta Rev Cancer. 2023 Sep 17:188988. doi: 10.1016/j.bbcan.2023.188988. Online ahead of print.ABSTRACTThe Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its involvement in cell proliferation has been discovered, the advantages of the Warburg effect in cancer cell survival under treatment have not been fully elucidated. In recent years, the metabolic characteristics of radioresistant cancer cells have been evaluated, enabling an extension of the original concept of the Warburg effect....
Source: Biochimica et Biophysica Acta - September 19, 2023 Category: Biochemistry Authors: Hyunkoo Kang Byeongsoo Kim Junhyeong Park HyeSook Youn BuHyun Youn Source Type: research
Paxillin interactome identified by SILAC and label-free approaches coupled to TurboID sheds light on the compositions of focal adhesions in mouse embryonic stem cells
This study illustrates the effectiveness of TurboID in mESCs. Importantly, we found that application of both SILAC and LF methods in combination allowed us to analyze the TurboID proteomics data in an unbiased, stringent and yet comprehensive manner.PMID:37725837 | DOI:10.1016/j.bbrc.2023.09.017
Source: Biochemical and Biophysical Research communications - September 19, 2023 Category: Biochemistry Authors: Qianqian He Siu Kwan Sze Kai Soon Ng Cheng-Gee Koh Source Type: research
Human umbilical cord mesenchymal stem cells-derived exosomes exert anti-inflammatory effects on osteoarthritis chondrocytes
Aging (Albany NY). 2023 Sep 18;15. doi: 10.18632/aging.205034. Online ahead of print.ABSTRACTInflammation of chondrocytes plays a critical role in the occurrence and development of osteoarthritis (OA). Recent evidence indicated exosomes derived from mesenchymal stem cells (MSCs-Exos) exhibit excellent anti-inflammatory ability in many troublesome inflammatory diseases including OA. In the present study, we aimed to explore the role of human umbilical cord-derived MSCs-Exos (hUC-MSCs-Exos) in treating the inflammation of chondrocytes and its related mechanisms. Ultracentrifugation was applied to isolate hUC-MSCs-Exos from t...
Source: Aging - September 19, 2023 Category: Biomedical Science Authors: Shichao Wang Wenyue Jiang Shuang Lv Zhicheng Sun Lihui Si Jinxin Hu Yang Yang Dingbang Qiu Xiaobin Liu Siying Zhu Lunhao Yang Ling Qi Guangfan Chi Guiqing Wang Pengdong Li Baojian Liao Source Type: research
Paxillin interactome identified by SILAC and label-free approaches coupled to TurboID sheds light on the compositions of focal adhesions in mouse embryonic stem cells
This study illustrates the effectiveness of TurboID in mESCs. Importantly, we found that application of both SILAC and LF methods in combination allowed us to analyze the TurboID proteomics data in an unbiased, stringent and yet comprehensive manner.PMID:37725837 | DOI:10.1016/j.bbrc.2023.09.017
Source: Biochemical and Biophysical Research communications - September 19, 2023 Category: Biochemistry Authors: Qianqian He Siu Kwan Sze Kai Soon Ng Cheng-Gee Koh Source Type: research
Heterogeneity in RAG 1/2 Deficiency: 35 Cases From A Single Center
This study aimed to define the clinical/laboratory spectrum of RAG1/2 deficiency. We retrospectively reviewed the clinical/laboratory data of 35 patients, grouped them as severe combined immunodeficiency (SCID), Omenn Syndrome (OS), and delayed-onset combined immunodeficiency (CID) and reported nine novel mutations. Male/female ratio was 23/12. Median age of clinical manifestations was 1 months (mo) (0.5-2), 2 mo (1.25-5), and 14 mo (3.63-27), age at diagnosis was 4 mo (3-6), 4.5 mo (2.5-9.75), and 27 mo (14.5-70) in SCID (n=25;71.4%), OS (n=5;14.3%), and CID (n=5;14.3%) patients, respectively. Common clinical manifestatio...
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Betul Karaatmaca Deniz Cagdas Saliha Esenboga Baran Erman Cagman Tan Tuba Turul Ozgur Kaan Boztug Mirjam Van Der Burg Ozden Sanal Ilhan Tezcan Source Type: research
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles loaded with TFCP2 activate Wnt/ β-catenin signaling to alleviate preeclampsia
CONCLUSION: From our data we conclude that hUCMSCs-EVs overexpressing TFCP2 may be instrumental for the therapeutic targeting and clinical management of PE.PMID:37724958 | DOI:10.1016/j.intimp.2023.109732
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Zhongmei Yang Xiaoyan Jia Qinyin Deng Mengdie Luo Yan Hou Jun Yue Jie Mei Nan Shan Zhao Wu Source Type: research
In vitro naive CD4 < sup > + < /sup > T cell differentiation upon treatment with miR-29b-loaded exosomes from mesenchymal stem cells
CONCLUSIONS: In conclusion, AMSC-Exo-based delivery of miR-29b can be considered as a new fascinating avenue for T cell differentiation inhibition and the future treatment of several inflammatory disorders.PMID:37725284 | DOI:10.1007/s11033-023-08767-w
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Zohreh Bolandi Seyed Mahmoud Hashemi Mozhgan Abasi Maryam Musavi Shahin Aghamiri Nastaran Miyanmahaleh Hossein Ghanbarian Source Type: research
Effect of miR-18a-5p, miR-19a-3p, and miR-20a-5p on < em > In Vitro < /em > Cardiomyocyte Differentiation of Human Endometrium Tissue-Derived Stem Cells Through Regulation of Smad4 Expression
CONCLUSION: Our results indicate that miR-18a-5p, miR-19a-3p, and miR-20a-5p are involved in the cardiac differentiation propensity of hEMSCs potentially by regulation of Smad levels. Although, more mechanistic experiments are required to confirm this idea.PMID:37724150 | PMC:PMC10505458 | DOI:10.52547/rbmb.12.1.136
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Behnaz Maleki Mahdi Noureddini Somayeh Saadat Javad Verdi Alireza Farrokhian Hossein Ghanbarian Ebrahim Cheraghi Behrang Alani Source Type: research
Evaluation of safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells in pediatric bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT)
CONCLUSIONS: AT-MSCs could be safely administered to our pediatric cases with BoS post-allo-HSCT. Considering their advanced stage of disease, their sub-optimal functional capacity due to steroid-induced complications, and COVID-19 infection post-treatment, we believe that AT-MSC therapy can have possible efficacy in the management of pediatric BoS. The conduction of further studies with larger sample sizes and more frequent injections is prudent for further optimization of AT-MSC therapy against BoS. Trial registration Iranian Registry of Clinical Trials (IRCT), IRCT20201202049568N2. Registered 22 February 2021, https://e...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Rashin Mohseni Pouya Mahdavi Sharif Maryam Behfar Mohammad Reza Modaresi Rohola Shirzadi Mahta Mardani Leila Jafari Fahimeh Jafari Zeynab Nikfetrat Amir Ali Hamidieh Source Type: research
