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Therapy: Stem Cell Therapy
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Liver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking
Neurobiol Dis. 2023 Sep 12:106293. doi: 10.1016/j.nbd.2023.106293. Online ahead of print.ABSTRACTSpastic paraplegia type 11 (SPG11) is a common autosomal recessive form of hereditary spastic paraplegia (HSP) characterized by the degeneration of cortical motor neuron axons, leading to muscle spasticity and weakness. Impaired lipid trafficking is an emerging pathology in neurodegenerative diseases including SPG11, though its role in axonal degeneration of human SPG11 neurons remains unknown. Here, we established a pluripotent stem cell-based SPG11 model by knocking down the SPG11 gene in human embryonic stem cells (hESCs). T...
Source: Neurobiology of Disease - September 14, 2023 Category: Neurology Authors: Eric Chai Zhenyu Chen Yongchao Mou Gitika Thakur Weihai Zhan Xue-Jun Li Source Type: research
Daratumumab and brentuximab vedotin combination therapy in T-cell acute lymphoblastic leukemia refractory to conventional chemotherapy and allogeneic stem cell transplant
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2023.283740. Online ahead of print.ABSTRACTNot available.PMID:37706335 | DOI:10.3324/haematol.2023.283740
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Kebede H Begna Nadine H Abdallah Michelle Janania-Martinez Abhishek A Mangaonkar Aruna Rangan Jennifer L Herrick Naseema Gangat Source Type: research
Induced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility
Annu Rev Genet. 2023 Sep 14. doi: 10.1146/annurev-genet-022123-090319. Online ahead of print.ABSTRACTMany human phenotypes are impossible to recapitulate in model organisms or immortalized human cell lines. Induced pluripotent stem cells (iPSCs) offer a way to study disease mechanisms in a variety of differentiated cell types while circumventing ethical and practical issues associated with finite tissue sources and postmortem states. Here, we discuss the broad utility of iPSCs in genetic medicine and describe how they are being used to study musculoskeletal, pulmonary, neurologic, and cardiac phenotypes. We summarize the p...
Source: Annual Review of Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Ayodeji Adegunsoye Natalia M Gonzales Yoav Gilad Source Type: research
The role of plasma-induced surface chemistry on polycaprolactone nanofibers to direct chondrogenic differentiation of human mesenchymal stem cells
This study investigates how different surface properties induced by either coating deposition or biomolecules immobilization onto nanofibers (NFs) could affect BMSCs chondro-inductive behavior. Accordingly, electrospun poly(ε-caprolactone) (PCL) NFs were exposed to two surface modification strategies based on medium-pressure plasma technology. The first strategy is plasma polymerization, in which cyclopropylamine (CPA) or acrylic acid (AcAc) monomers were plasma polymerized to obtain amine- or carboxylic acid-rich NFs, respectively. The second strategy uses a combination of CPA plasma polymerization and a post-chemical te...
Source: Biomed Res - September 14, 2023 Category: Research Authors: Mahtab Asadian Clarissa Tomasina Yuliia Onyshchenko Ke Vin Chan Mohammad Norouzi Jip Zonderland Sandra Camarero-Espinosa Rino Morent Nathalie De Geyter Lorenzo Moroni Source Type: research
Anti-inflammatory protein TSG-6 secreted by BMSCs attenuates silica-induced acute pulmonary inflammation by inhibiting NLRP3 inflammasome signaling in macrophages
In this study, we focused on the early phase of silica-induced lung injury to investigate the therapeutic effect of BMSCs. Our findings demonstrated that BMSCs attenuated silica-induced acute pulmonary inflammation by inhibiting NLRP3 inflammasome pathways in lung macrophages. To further understand the mechanisms involved, we utilized RNA sequencing to analyze the transcriptomes of BMSCs co-cultured with silica-stimulated bone marrow-derived macrophages (BMDMs). The results clued tumor necrosis factor-stimulated gene 6 (TSG-6) might be a potentially key paracrine secretion factor released from BMSCs, which exerts a protect...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Wenyao Su Qiying Nong Jie Wu Ruihong Fan Yuanting Liang Anyi Hu Zhongxiang Gao Weihui Liang Qifei Deng Hailan Wang Lihua Xia Yongshun Huang Yiru Qin Na Zhao Source Type: research
Treg-targeted IL-2/anti-IL-2 complex controls graft- < em > versus < /em > -host disease and supports anti-tumor effect in allogeneic hematopoietic stem cell transplantation
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2022.282653. Online ahead of print.ABSTRACTModulating an immune response in opposite directions represents the holy grail in allogeneic hematopoietic stem cell transplantation (allo-HSCT) to avoid insufficient reactivity of donor T cells and hematologic malignancy relapse while controlling the potential development of graft-versus-host disease (GVHD), in which donor T cells attack the recipient's tissues. IL-2/anti-IL-2 complexes (IL2-Cxs) represents a therapeutic option to selectively accentuate or dampen the immune response. In dedicated experimental models of allo-HSCT, ...
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Allan Thiolat Caroline Pilon Pamela Caudana Audrey Moatti Nhu Hanh To Christine Sedlik Mathieu Leclerc S ébastien Maury Eliane Piaggio Jos é L Cohen Source Type: research
Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage
Aging (Albany NY). 2023 Sep 14;15. doi: 10.18632/aging.205026. Online ahead of print.ABSTRACTPathological cardiac hypertrophy is a considerable contributor to global disease burden. Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since antiquity. Enhancing stem cell-mediated recovery through CHM represents a promising approach for protection against doxorubicin (Dox)-induced cardiac hypertrophy. Herein, we investigated whether human adipose-derived stem cells (hADSCs) preconditioned with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin-induced ...
Source: Aging - September 14, 2023 Category: Biomedical Science Authors: Dennis Jine-Yuan Hsieh Bruce Chi-Kang Tsai Parthasarathi Barik Marthandam Asokan Shibu Chia-Hua Kuo Wei-Wen Kuo Pi-Yu Lin Cheng-Yen Shih Shinn-Zong Lin Tsung-Jung Ho Chih-Yang Huang Source Type: research
Daratumumab and brentuximab vedotin combination therapy in T-cell acute lymphoblastic leukemia refractory to conventional chemotherapy and allogeneic stem cell transplant
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2023.283740. Online ahead of print.ABSTRACTNot available.PMID:37706335 | DOI:10.3324/haematol.2023.283740
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Kebede H Begna Nadine H Abdallah Michelle Janania-Martinez Abhishek A Mangaonkar Aruna Rangan Jennifer L Herrick Naseema Gangat Source Type: research
Liver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking
Neurobiol Dis. 2023 Sep 12:106293. doi: 10.1016/j.nbd.2023.106293. Online ahead of print.ABSTRACTSpastic paraplegia type 11 (SPG11) is a common autosomal recessive form of hereditary spastic paraplegia (HSP) characterized by the degeneration of cortical motor neuron axons, leading to muscle spasticity and weakness. Impaired lipid trafficking is an emerging pathology in neurodegenerative diseases including SPG11, though its role in axonal degeneration of human SPG11 neurons remains unknown. Here, we established a pluripotent stem cell-based SPG11 model by knocking down the SPG11 gene in human embryonic stem cells (hESCs). T...
Source: Neurobiology of Disease - September 14, 2023 Category: Neurology Authors: Eric Chai Zhenyu Chen Yongchao Mou Gitika Thakur Weihai Zhan Xue-Jun Li Source Type: research
Bortezomib and Vorinostat Therapy as Maintenance Therapy Post Autologous Transplant for Non-Hodgkin's Lymphoma Using R-BEAM or BEAM Transplant Conditioning Regimen
CONCLUSIONS: BV can be given post-ASCT for NHL and produces excellent disease-free and overall survival rates.PMID:37708877 | DOI:10.1159/000533944
Source: Acta Haematologica - September 14, 2023 Category: Hematology Authors: Leona A Holmberg David G Maloney Laura Connelly-Smith Source Type: research
Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage
Aging (Albany NY). 2023 Sep 14;15. doi: 10.18632/aging.205026. Online ahead of print.ABSTRACTPathological cardiac hypertrophy is a considerable contributor to global disease burden. Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since antiquity. Enhancing stem cell-mediated recovery through CHM represents a promising approach for protection against doxorubicin (Dox)-induced cardiac hypertrophy. Herein, we investigated whether human adipose-derived stem cells (hADSCs) preconditioned with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin-induced ...
Source: Aging - September 14, 2023 Category: Biomedical Science Authors: Dennis Jine-Yuan Hsieh Bruce Chi-Kang Tsai Parthasarathi Barik Marthandam Asokan Shibu Chia-Hua Kuo Wei-Wen Kuo Pi-Yu Lin Cheng-Yen Shih Shinn-Zong Lin Tsung-Jung Ho Chih-Yang Huang Source Type: research
Bortezomib and Vorinostat Therapy as Maintenance Therapy Post Autologous Transplant for Non-Hodgkin's Lymphoma Using R-BEAM or BEAM Transplant Conditioning Regimen
CONCLUSIONS: BV can be given post-ASCT for NHL and produces excellent disease-free and overall survival rates.PMID:37708877 | DOI:10.1159/000533944
Source: Acta Haematologica - September 14, 2023 Category: Hematology Authors: Leona A Holmberg David G Maloney Laura Connelly-Smith Source Type: research
Illuminating the path to shoot meristem regeneration: Molecular insights into reprogramming cells into stem cells
Curr Opin Plant Biol. 2023 Sep 13:102452. doi: 10.1016/j.pbi.2023.102452. Online ahead of print.ABSTRACTPlant cells possess the ability to dedifferentiate and reprogram into stem cell-like populations, enabling the regeneration of new organs. However, the maintenance of stem cells relies on specialized microenvironments composed of distinct cell populations with specific functions. Consequently, the regeneration process necessitates the orchestrated regulation of multiple pathways across diverse cellular populations. One crucial pathway involves the transcription factor WUSCHEL HOMEOBOX 5 (WOX5), which plays a pivotal role...
Source: Current Opinion in Plant Biology - September 14, 2023 Category: Biology Authors: Yetkin Çaka Ince Keiko Sugimoto Source Type: research
The stomatal fates: Understanding initiation and enforcement of stomatal cell fate transitions
Curr Opin Plant Biol. 2023 Sep 12:102449. doi: 10.1016/j.pbi.2023.102449. Online ahead of print.ABSTRACTIn the stomatal lineage, repeated arcs of initiation, stem-cell proliferation, and terminal cell fate commitment are displayed on the surface of aerial organs. Over the past two decades, the core transcription and signaling elements that guide cell divisions, patterning, and fate transitions were defined. Here we highlight recent work that extends the core using a variety of cutting-edge techniques in different plant species. New work has discovered transcriptional circuits that initiate and reinforce stomatal fate trans...
Source: Current Opinion in Plant Biology - September 14, 2023 Category: Biology Authors: Margot E Smit Dominique C Bergmann Source Type: research
