Filtered By:
Therapy: Stem Cell Therapy

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 54597 results found since Jan 2013.

IJERPH, Vol. 18, Pages 2382: How Knowledge about Stem Cells Influences Attitudes towards Breastfeeding: Case Study of Polish Women
yna Maternal breastfeeding is associated with multiple health benefits, both for the child and the mother. Since breastfeeding rates are declining, finding new, future-oriented strategies to strengthen and support mothers’ positive attitudes towards breastfeeding need to be developed. In this paper, we describe how information about the presence of stem cells in breast milk can influence the willingness to breastfeed in the population of Polish pregnant women. A cross-sectional study involving a group of 150 pregnant women was conducted to assess the correlation between their knowledge about stem cells and their atti...
Source: International Journal of Environmental Research and Public Health - March 1, 2021 Category: Environmental Health Authors: Malgorzata Witkowska-Zimny Dorota Majczyna Tags: Article Source Type: research

Abstract 4105: Prevalence of breast stem cells in high-risk benign breast lesions and association with breastfeeding
Conclusion: This is the first report, to our knowledge, that stem cells are present in some high-risk lesions and their associated normal breast tissue. Correlation with future development of invasive breast cancer could lay the foundation for future targeted breast cancer prevention strategies. Citation Format: Rachel L. Atkinson, Fraser Symmans, Therese B. Bevers, Wendy A. Woodward, Abenaa M. Brewster. Prevalence of breast stem cells in high-risk benign breast lesions and association with breastfeeding. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Atkinson, R. L., Symmans, F., Bevers, T. B., Woodward, W. A., Brewster, A. M. Tags: Prevention Research Source Type: research

Is a Matched Unrelated Donor Search Needed for All Allogeneic Transplant Candidates?
ConclusionsRace, haplotype frequency and disease status at the time of MUD search influence probability to identify a MUD and receive a transplant. Patients with low likelihood to receive a MUD transplant may proceed to a haploidentical transplant as soon as indicated, as this approach does not appear to compromise transplant outcomes.DisclosuresKonopleva: Stemline Therapeutics: Research Funding. Oran: AROG pharmaceuticals: Research Funding; Celgene: Consultancy, Research Funding; ASTEX: Research Funding. Champlin: Otsuka: Research Funding; Sanofi: Research Funding.
Source: Blood - November 21, 2018 Category: Hematology Authors: Ciurea, S. O., Borges Bittencourt, M. C., Milton, D. R., Cao, K., Kongtim, P., Rondon, G., Chen, J., Konopleva, M. Y., Ramos Perez, J. M., Elshazly, M., Aljadayeh, M., Alvarez, M., Im, J. S., Alatrash, G., Mehta, R. S., Popat, U., Bashir, Q., Oran, B., Ho Tags: 732. Clinical Allogeneic Transplantation: Results: Poster II Source Type: research

Outcome of patients activating an unrelated donor search for severe acquired aplastic anemia
This study analyzes the outcome of ATG‐refractory SAA patients activating a VUD search. Of 179 patients, 68 had at least one HLA‐A, –B and –DR matched donor identified and underwent HSCT while 50 also with a donor were not transplanted because of early death (8), late response to IST (34), transplant refusal (1) or other (7). Conversely, 61 had no matched donor, 13 of those ultimately received a mismatched HSCT. All but one received marrow stem cells. Among patients aged <17 years, those with at least one matched donor had a significant higher 4‐year survival as compared to others (79%+/‐6% versus 53%+/‐10...
Source: American Journal of Hematology - June 27, 2013 Category: Hematology Authors: Sébastien Maury, Marie‐Lorraine Balère‐Appert, Simona Pollichieni, Rosi Oneto, Ibrahim Yakoub‐Agha, Franco Locatelli, Jean‐Hugues Dalle, Edoardo Lanino, Alain Fischer, Andrea Pession, Anne Huynh, Walter Barberi, Mohamad Mohty, Antonio Risitano, Tags: Research Article Source Type: research

Influence of the HLA characteristics of Italian patients on donor search outcome in unrelated hematopoietic stem cell transplantation
In this study, we retrospectively analyzed 315 Italian patients who started a search for a MUD, in order to assess the distribution of human leukocyte antigen (HLA) alleles and haplotypes in this population of patients and to evaluate the probability of finding a donor. Comparing two groups of patients based on whether or not a 10/10 HLA‐matched donor was available, we found that patients who had a fully‐matched MUD possessed at least one frequent haplotype more often than the others (45.6% vs 14.3%; P = 0.000003). In addition, analysis of data pertaining to the HLA class I alleles distribution showed that, in the ...
Source: Tissue Antigens - April 18, 2014 Category: Allergy & Immunology Authors: M. Testi, M. Andreani, F. Locatelli, W. Arcese, M. Troiano, M. Battarra, J. Gaziev, G. Lucarelli Tags: Original article Source Type: research

Close to the bone — in search of the skeletal stem cell
Close to the bone — in search of the skeletal stem cell, Published online: 13 November 2018; doi:10.1038/s41584-018-0121-6The search for the identity of skeletal stem cells has reached a point at which skeletogenic cell populations with self-renewing capacity can be enriched and studied in detail. These advances provide new hope for skeletal regenerative medicine.
Source: Nature Reviews Rheumatology - November 13, 2018 Category: Rheumatology Authors: Frank P. Luyten Scott J. Roberts Source Type: research

Outcomes of strategic alternative donor selection or suspending donor search based on Japan Marrow Donor Program coordination status.
Abstract In allogeneic hematopoietic stem cell transplantation (allo-HSCT) from unrelated donors, delays in donor search are adversely associated with patient outcome. However, the optimal duration for either waiting for an unrelated donor or selecting alternative sources remains undetermined. Using data from the Japan Marrow Donor Program (JMDP) registry, we retrospectively analyzed 349 adult patients who had searched for unrelated donors. Two hundred and three patients received allo-HSCT from JMDP donors (Group A) with a median of 140 days required to identify a donor, 60 received allo-HSCT from alternative sou...
Source: International Journal of Hematology - January 27, 2018 Category: Hematology Authors: Kawashima N, Nishiwaki S, Shimizu N, Kamoshita S, Watakabe K, Yokohata E, Kurahashi S, Ozawa Y, Miyamura K Tags: Int J Hematol Source Type: research

Molecules, Vol. 23, Pages 567: Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search
heng Luo Kai Chen SET7, serving as the only histone methyltransferase that monomethylates ‘Lys-4’ of histone H3, has been proved to function as a key regulator in diverse biological processes, such as cell proliferation, transcriptional network regulation in embryonic stem cell, cell cycle control, protein stability, heart morphogenesis and development. What′s more, SET7 is involved inthe pathogenesis of alopecia aerate, breast cancer, tumor and cancer progression, atherosclerosis in human carotid plaques, chronic renal diseases, diabetes, obesity, ovarian cancer, prostate cancer, hepatocellular carcinoma, and ...
Source: Molecules - March 2, 2018 Category: Chemistry Authors: Hong Ding Wen Lu Jun Hu Yu-Chih Liu Chen Zhang Fu Lian Nai Zhang Fan Meng Cheng Luo Kai Chen Tags: Article Source Type: research

Improved accuracy of clinical HLA genotyping by next-generation DNA sequencing affects unrelated donor search results for hematopoietic stem cell transplantation.
Abstract Matching of human leukocyte antigen (HLA) genes is critically important in hematopoietic stem cell transplantation (HSCT). HLA genes are highly polymorphic and HLA matching has historically been limited by technologies that are unable to unambiguously determine HLA genotypes. Next generation DNA sequencing (NGS) overcomes these limitations by enabling near full-gene sequences with phase determination for heterozygous alleles. Here we examine the efficacy and utility of HLA-NGS in the clinical setting. In a 54-sample validation study and 955 patient samples subsequently tested using HLA-NGS, we observed si...
Source: Human Immunology - October 11, 2018 Category: Allergy & Immunology Authors: Allen ES, Yang B, Garrett J, Ball ED, Maiers M, Morris GP Tags: Hum Immunol Source Type: research

Glycan Markers of Human Stem Cells Assigned with Beam Search Arrays.
Abstract Glycan antigens recognized by monoclonal antibodies have served as stem cell markers. To understand regulation of their biosynthesis and their roles in stem cell behavior precise assignments are required. We have applied state-of-the-art glycan array technologies to compare the glycans bound by five antibodies that recognize carbohydrates on human stem cells. These are: FC10.2, TRA-1-60, TRA-1-81, anti-i and R-10G. Microarray analyses with a panel of sequence-defined glycans corroborate that FC10.2, TRA-1-60, TRA-1-81 recognize the type 1-(Galβ-3GlcNAc)-terminating backbone sequence, Galβ-3GlcNAcβ-3Gal...
Source: Molecular and Cellular Proteomics : MCP - July 14, 2019 Category: Molecular Biology Authors: Wu N, Silva LM, Liu Y, Zhang Y, Gao C, Zhang F, Fu L, Peng Y, Linhardt R, Kawasaki T, Mulloy B, Chai W, Feizi T Tags: Mol Cell Proteomics Source Type: research

GSE192644 Studying heterogeneity in embryonic stem cells using the approach of search-engine
Contributors : Kedar N Natrajan ; Vibhor KumarSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHere we designed a search-engine for single-cell epigenome profiles. We tested different application of search-engine using different data-sets including mESC scATAC-seq profile.
Source: GEO: Gene Expression Omnibus - December 27, 2022 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

In search of the pivot point of mechanotransduction: Mechanosensing of stem cells.
This article mainly focuses on the mechanosensing, which is the upstream event of stem cell mechanotransduction and the downstream one of physical stimuli. Putative mechanosensors such as ion channels, integrins, cell membrane, as well as primary cilia are discussed. Since mechanical environment is an important stem cell niche, identification of mechanosensors can not only elucidate the mechanisms of mechanotransduction and fate commitments, but also bring new prospects of the mechanical control as well as drug development for clinical application. PMID: 23294564 [PubMed - as supplied by publisher]
Source: Cell Transplantation - January 2, 2013 Category: Cytology Authors: Liu YS, Lee OK Tags: Cell Transplant Source Type: research

In situ Search for Breast Cancer Stem Cells and Their Niche: The Film Sheet Epoxy Resin Embedding Method and Breast Cancer Stem Cells.
PMID: 23832410 [PubMed - in process]
Source: Journal of Nippon Medical School - July 11, 2013 Category: Universities & Medical Training Authors: Yamamoto Y, Oguro T, Mieda J, Ohashi R, Tsuchiya S Tags: J Nippon Med Sch Source Type: research

In Search of Mechanisms Associated with Mesenchymal Stem Cell-Based Therapies for Acute Kidney Injury.
Abstract Acute kidney injury (AKI) is classically described as a rapid loss of kidney function. AKI affects more than 15% of all hospital admissions and is associated with elevated mortality rates. Although many advances have occurred, intermittent or continuous renal replacement therapies are still considered the best options for reversing mild and severe AKI syndrome. For this reason, it is essential that innovative and effective therapies, without side effects and complications, be developed to treat AKI and the end-stages of renal disease. Mesenchymal stem cell (MSC) based therapies have numerous advantages in...
Source: The Clinical Biochemist. Reviews - November 1, 2013 Category: Biochemistry Authors: de Almeida DC, Donizetti-Oliveira C, Barbosa-Costa P, Origassa CS, Câmara NO Tags: Clin Biochem Rev Source Type: research

In search of the pivot point of mechanotransduction: mechanosensing of stem cells.
This article mainly focuses on the mechanosensing, which is the upstream event of stem cell mechanotransduction and the downstream one of physical stimuli. Putative mechanosensors such as ion channels, integrins, and cell membrane as well as primary cilia are discussed. Because mechanical environment is an important stem cell niche, identification of mechanosensors not only can elucidate the mechanisms of mechanotransduction and fate commitments but also bring new prospects of the mechanical control as well as drug development for clinical application. PMID: 24439034 [PubMed - in process]
Source: Cell Transplantation - January 24, 2014 Category: Cytology Authors: Liu YS, Lee OK Tags: Cell Transplant Source Type: research