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Therapy: Stem Cell Therapy

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Treg-targeted IL-2/anti-IL-2 complex controls graft- < em > versus < /em > -host disease and supports anti-tumor effect in allogeneic hematopoietic stem cell transplantation
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2022.282653. Online ahead of print.ABSTRACTModulating an immune response in opposite directions represents the holy grail in allogeneic hematopoietic stem cell transplantation (allo-HSCT) to avoid insufficient reactivity of donor T cells and hematologic malignancy relapse while controlling the potential development of graft-versus-host disease (GVHD), in which donor T cells attack the recipient's tissues. IL-2/anti-IL-2 complexes (IL2-Cxs) represents a therapeutic option to selectively accentuate or dampen the immune response. In dedicated experimental models of allo-HSCT, ...
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Allan Thiolat Caroline Pilon Pamela Caudana Audrey Moatti Nhu Hanh To Christine Sedlik Mathieu Leclerc S ébastien Maury Eliane Piaggio Jos é L Cohen Source Type: research

Daratumumab and brentuximab vedotin combination therapy in T-cell acute lymphoblastic leukemia refractory to conventional chemotherapy and allogeneic stem cell transplant
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2023.283740. Online ahead of print.ABSTRACTNot available.PMID:37706335 | DOI:10.3324/haematol.2023.283740
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Kebede H Begna Nadine H Abdallah Michelle Janania-Martinez Abhishek A Mangaonkar Aruna Rangan Jennifer L Herrick Naseema Gangat Source Type: research

Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage
Aging (Albany NY). 2023 Sep 14;15. doi: 10.18632/aging.205026. Online ahead of print.ABSTRACTPathological cardiac hypertrophy is a considerable contributor to global disease burden. Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since antiquity. Enhancing stem cell-mediated recovery through CHM represents a promising approach for protection against doxorubicin (Dox)-induced cardiac hypertrophy. Herein, we investigated whether human adipose-derived stem cells (hADSCs) preconditioned with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin-induced ...
Source: Aging - September 14, 2023 Category: Biomedical Science Authors: Dennis Jine-Yuan Hsieh Bruce Chi-Kang Tsai Parthasarathi Barik Marthandam Asokan Shibu Chia-Hua Kuo Wei-Wen Kuo Pi-Yu Lin Cheng-Yen Shih Shinn-Zong Lin Tsung-Jung Ho Chih-Yang Huang Source Type: research

Induced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility
Annu Rev Genet. 2023 Sep 14. doi: 10.1146/annurev-genet-022123-090319. Online ahead of print.ABSTRACTMany human phenotypes are impossible to recapitulate in model organisms or immortalized human cell lines. Induced pluripotent stem cells (iPSCs) offer a way to study disease mechanisms in a variety of differentiated cell types while circumventing ethical and practical issues associated with finite tissue sources and postmortem states. Here, we discuss the broad utility of iPSCs in genetic medicine and describe how they are being used to study musculoskeletal, pulmonary, neurologic, and cardiac phenotypes. We summarize the p...
Source: Annual Review of Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Ayodeji Adegunsoye Natalia M Gonzales Yoav Gilad Source Type: research

Scalable mesenchymal stem cell enrichment from bone marrow aspirate using deterministic lateral displacement (DLD) microfluidic sorting
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Nicholas Tan Kwan Zen, Kerwin Kwek Zeming, Kim Leng Teo, Mavis Loberas, Jialing Lee, Chin Ren Goh, Da Hou Yang, Steve Oh, James Hui Hoi Po, Simon M. Cool, Han Wei Hou, Jongyoon Han MSCs are enriched twice more efficiently with 10-fold shorten processing time from undiluted human bone marrow aspirate. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - September 13, 2023 Category: Chemistry Authors: Nicholas Tan Kwan Zen Source Type: research

OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research

Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain
Cell Metab. 2023 Sep 7:S1550-4131(23)00304-2. doi: 10.1016/j.cmet.2023.08.009. Online ahead of print.ABSTRACTWeight regain after weight loss is a major challenge in the treatment of obesity. Immune cells adapt to fluctuating nutritional stress, but their roles in regulating weight regain remain unclear. Here, we identify a stem cell-like CD7+ monocyte subpopulation accumulating in the bone marrow (BM) of mice and humans that experienced dieting-induced weight loss. Adoptive transfer of CD7+ monocytes suppresses weight regain, whereas inducible depletion of CD7+ monocytes accelerates it. These cells, accumulating metabolic ...
Source: Cell Metabolism - September 13, 2023 Category: Cytology Authors: Hai-Yan Zhou Xu Feng Li-Wen Wang Rui Zhou Heng Sun Xin Chen Ren-Bin Lu Yan Huang Qi Guo Xiang-Hang Luo Source Type: research

Integrated modeling framework reveals co-regulation of transcription factors, miRNAs and lncRNAs on cardiac developmental dynamics
CONCLUSIONS: In conclusion, we find that hPSC-CMs are regulated in a cell autonomous manner during early development that diverges significantly as a function of time when compared to in vivo derived CMs. These findings demonstrate the feasibility of using CGRM to reveal dynamic and complex transcriptional and posttranscriptional regulatory interactions that underlie cell directed versus environment-dependent CM development. These results with in vitro versus in vivo derived CMs thus establish this approach for detailed analyses of heart disease and for the analysis of cell regulatory systems in other biomedical fields.PMI...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Shumin Li Bin Yan Binbin Wu Junhao Su Jianliang Lu Tak-Wah Lam Kenneth R Boheler Ellen Ngar-Yun Poon Ruibang Luo Source Type: research

SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes
CONCLUSION: Overall, our findings uncover the extensive damaging effects of Nsp6, Nsp8, and M on hPSC-CMs, underlining the crucial role of ATP homeostasis in CM death and functional abnormalities induced by these SARS-CoV-2 genes, and reveal the potential therapeutic strategies to alleviate these detrimental effects with FDA-approved drugs.PMID:37705046 | DOI:10.1186/s13287-023-03485-3
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Juli Liu Shiyong Wu Yucheng Zhang Cheng Wang Sheng Liu Jun Wan Lei Yang Source Type: research

Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models
This study revealed the anti-inflammatory properties of UCMSC-CM and its regulatory effect on glial activation in the treatment of neuroinflammation in ALS, providing strong evidence for the clinical application of UCMSC-CM.PMID:37704056 | DOI:10.1016/j.brainresbull.2023.110760
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Jingshu Tang Yuying Kang Yujun Zhou Qiuyu Chen Jiaqi Lan Xuebin Liu Ying Peng Source Type: research

Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases
Regen Med. 2023 Sep 13. doi: 10.2217/rme-2023-0089. Online ahead of print.ABSTRACTResearch has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential the...
Source: Regenerative Medicine - September 13, 2023 Category: Genetics & Stem Cells Authors: Wesley Harrisson Bouche Djatche Huimin Zhu Wenlei Ma Yue Li Ziang Li Hong Zhao Zhizhen Liu Hua Qiao Source Type: research

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