SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes
CONCLUSION: Overall, our findings uncover the extensive damaging effects of Nsp6, Nsp8, and M on hPSC-CMs, underlining the crucial role of ATP homeostasis in CM death and functional abnormalities induced by these SARS-CoV-2 genes, and reveal the potential therapeutic strategies to alleviate these detrimental effects with FDA-approved drugs.PMID:37705046 | DOI:10.1186/s13287-023-03485-3
Source: Cell Research - Category: Cytology Authors: Juli Liu Shiyong Wu Yucheng Zhang Cheng Wang Sheng Liu Jun Wan Lei Yang Source Type: research
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