Integrated modeling framework reveals co-regulation of transcription factors, miRNAs and lncRNAs on cardiac developmental dynamics

CONCLUSIONS: In conclusion, we find that hPSC-CMs are regulated in a cell autonomous manner during early development that diverges significantly as a function of time when compared to in vivo derived CMs. These findings demonstrate the feasibility of using CGRM to reveal dynamic and complex transcriptional and posttranscriptional regulatory interactions that underlie cell directed versus environment-dependent CM development. These results with in vitro versus in vivo derived CMs thus establish this approach for detailed analyses of heart disease and for the analysis of cell regulatory systems in other biomedical fields.PMID:37705079 | DOI:10.1186/s13287-023-03442-0

Source: Cell Research - September 13, 2023 Category: Cytology Authors: Shumin Li Bin Yan Binbin Wu Junhao Su Jianliang Lu Tak-Wah Lam Kenneth R Boheler Ellen Ngar-Yun Poon Ruibang Luo Source Type: research