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Vaccination: Pneomococcal Vaccine

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Total 244 results found since Jan 2013.

The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology
Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations. Introduction Although influenza virus was recognized as an important pathogen over a century ago, influenza continues to cause a significant burden of disease. In the United States alone, it's estimated that in the 2017–2018 season there were 959,000 hospitalizations related to influenza illness, and 79,400 deaths (CDC, 2018). Worldwide, WHO estimates that annual influen...
Source: Frontiers in cellular and infection microbiology - April 16, 2019 Category: Microbiology Source Type: research

Keeping Athletes Healthy at the 2020 Tokyo Summer Games: Considerations and Illness Prevention Strategies
Conclusion It is apparent that athletes will be exposed to various stressors during both the preparatory and competition phases of the Summer Games. Athletes residing in the southern hemisphere appear to be at increased risk for illness during the preparatory phase, while female, Paralympic, water-sport and multi-competition/event athletes may be more susceptible to illness during the competition phase of the Summer Games. To maintain athlete health, illness prevention strategies should be targeted to stressors and at-risk athletes. Keeping athletes healthy will contribute to optimal Olympic and Paralympic athletic perfor...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome
This study was carried out after written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Stanford University and UCLA Institutional Review Boards. Author Contributions MB provided patient care and obtained IRB approval. RO prepared histology images. MB, TT, and RB designed the research. TT and LP conducted experiments and analyzed data. MB made the molecular model. MB and TT wrote the manuscript. Funding Funding for this work came from the Jeffrey Modell Foundation and from the NIH/NIGMS (R01 GM110482 to MB)....
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

B Cell Reconstitution and Influencing Factors After Hematopoietic Stem Cell Transplantation in Children
Nicolaas G. van der Maas, Dagmar Berghuis, Mirjam van der Burg and Arjan C. Lankester* Willem-Alexander Children's Hospital, Department of Pediatrics and Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, Netherlands B cell reconstitution after hematopoietic stem cell transplantation (HSCT) is variable and influenced by different patient, donor, and treatment related factors. In this review we describe B cell reconstitution after pediatric allogeneic HST, including the kinetics of reconstitution of the different B cell subsets and the development of the B cell repertoire, and d...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Interpretation of post–pneumococcal vaccine antibody levels: Concerns and pitfalls
Publication date: March 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 3Author(s): Caitlin M.G. McNulty, James T. Li
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 4, 2019 Category: Allergy & Immunology Source Type: research

Severe Necrotic Reaction to 23-Valent Polysaccharide Pneumococcal Vaccine in a Patient With STAT3 Deficiency
Publication date: Available online 15 February 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Mervin Piñones, Cecilia Vizcaya, Guillermo Pérez-Mateluna, Rodrigo Hoyos-Bachiloglu, Arturo Borzutzky
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 16, 2019 Category: Allergy & Immunology Source Type: research

Every Breath You Take – Improving Asthma Wellness
Good control of asthma reduces related deaths and costs. The CDC recommends pneumococcal vaccination for patients with asthma, aged 18-64 years. Guidelines recommend assessment and documentation of asthma severity at each clinic visit. Objectives were to determine whether specific interventions would improve rates of pneumococcal vaccination and asthma severity documentation in asthma patients.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Aparna S. Daley Source Type: research

Predicting Patient Response To Pneumococcal 23-vaccine (PPV23) Using Age, Baseline Immunoglobulins, and Pneumococcal Serotypes
The pneumococcal polysaccharide 23-serotype vaccine (PPV23) is an integral part of the evaluation and diagnosis of humoral antibody deficiencies. Although there are guidelines on how to interpret overall vaccine responses, there is a paucity of evidence on the significance of individual serotypes as possible predictors of immunodeficiency or future risk of immunodeficiency.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Rayna J. Doll, David McGarry, Nancy Joseph, Jack Jeskey, Linda Quinn, Devi Jhaveri, Haig Tcheurekdjian, Robert W. Hostoffer Source Type: research

Effect of pneumococcal conjugate vaccine introduction on childhood pneumonia mortality in Brazil: a retrospective observational study
Publication date: February 2019Source: The Lancet Global Health, Volume 7, Issue 2Author(s): Cynthia Schuck-Paim, Robert J Taylor, Wladimir J Alonso, Daniel M Weinberger, Lone SimonsenSummaryBackgroundUnderstanding the real-world effect of pneumococcal conjugate vaccines (PCVs) on pneumonia mortality is crucial because of the expectation that increased PCV use will substantially reduce the burden of pneumonia deaths in children younger than 5 years. However, few post-vaccine introduction studies have estimated the benefits of PCV use on childhood mortality and results have been inconsistent. Therefore, we set out to assess...
Source: The Lancet Global Health - January 24, 2019 Category: International Medicine & Public Health Source Type: research

Interpretation of Post-Pneumococcal Vaccine Antibody Levels: Concerns and Pitfalls
Publication date: Available online 27 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Caitlin MG. McNulty, James T. Li
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 28, 2018 Category: Allergy & Immunology Source Type: research

Differentiation of Common Variable Immunodeficiency from Igg Deficiency
ConclusionCVID and IgG deficiency do not share the same disease spectrum, the former being associated with immunodysregulative manifestations and markers of a more severe immune defect. These data may allow clinicians to distinguish these conditions and the management differences that these patients pose.
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 15, 2018 Category: Allergy & Immunology Source Type: research

CbpM and CbpG of Streptococcus Pneumoniae Elicit a High Protection in Mice Challenged with a Serotype 19F Pneumococcus.
This study aims to determine the immunogenicity of CbpM, CbpG and CbpL proteins of Streptococcus pneumoniae in a mice model. The genes were cloned into pET21a expression vector and the recombinant proteins were produced. Mice were immunized with the purified recombinant proteins. Subsequently, the mice were challenged with S. pneumoniae ATCC 49619 (2×106 CFU) and their survival and bacterial clearances were followed 24 hours after infection. The antibody responses of the mice were determined by ELISA assay. The opsonophagocytosis assay was performed using rabbit's sera. Passive immunization was carried out using two doses...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 3, 2018 Category: Allergy & Immunology Authors: Kazemian H, Afshar D, Garcia E, Pourmand MR, Jeddi-Tehrani M, Aminharati F, Shokri F, Yazdi MH Tags: Iran J Allergy Asthma Immunol Source Type: research

Interlaboratory variability in multiplexed pneumococcal antibody testing
Assays that measure levels of IgG antibodies against specific serotypes of Streptococcus pneumoniae were initially developed and subsequently refined primarily for evaluation of vaccine efficacy.1 Because polysaccharide vaccines represent a well-defined immunogenic stimulus, measurement of serotype-specific antibody production in response to vaccination with the pneumococcal polysaccharide vaccine (PPV23) has also been used to evaluate humoral immune function in cases of suspected primary immune deficiency disease (PIDD).
Source: Journal of Allergy and Clinical Immunology - November 20, 2018 Category: Allergy & Immunology Authors: David C. LaFon, Moon H. Nahm Tags: Letter to the Editor Source Type: research

A new diagnosis of cvid in a pediatric patient presenting with streptococcus pneumoniae meningitis
Common Variable Immune Deficiency (CVID) can present with a range of organ system involvement, including normal number of B-cells but decreased IgG, eventual decline in IgA and/or IgM, and poor/absent response to vaccinations.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: K. Schissler, C. Ortega, V. Hernandez-Trujillo, J. Calderon Tags: M273 Source Type: research

Prefusion HPIV F Immunogens and Their Use.
Human parainfluenza virus (hPIV) is an RNA-based paramyxovirus that causes respiratory infections in children and adults. There are four serotypes that can result in a myriad of diseases of the respiratory tract including croup, bronchitis, and pneumonia (Mao et al., 2012). hPIV is a leading cause of respiratory tract infection and hospitalization among children under 5, only surpassed by the respiratory syncytial virus (RSV). Currently, there are limited treatment options and no approved vaccines. Recently, studies showed that a large proportion of neutralizing antibodies preferentially recognize exposed epitopes in the p...
Source: NIH OTT Licensing Opportunities - August 31, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research