Interlaboratory variability in multiplexed pneumococcal antibody testing

Assays that measure levels of IgG antibodies against specific serotypes of Streptococcus pneumoniae were initially developed and subsequently refined primarily for evaluation of vaccine efficacy.1 Because polysaccharide vaccines represent a well-defined immunogenic stimulus, measurement of serotype-specific antibody production in response to vaccination with the pneumococcal polysaccharide vaccine (PPV23) has also been used to evaluate humoral immune function in cases of suspected primary immune deficiency disease (PIDD).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research