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Total 331 results found since Jan 2013.

True Allergy to Amide Local Anesthetics: A Review and Case Presentation.
We report a case of a 43-year-old female patient that presented to NYU Lutheran Medical Center Dental Clinic with a documented history of allergy to amide local anesthetics. This case report reviews the use of 1% diphenhydramine with 1:100,000 epinephrine as an alternative local anesthetic and reviews the relevant literature. PMID: 29952645 [PubMed - in process]
Source: Anesthesia Progress - June 30, 2018 Category: Anesthesiology Tags: Anesth Prog Source Type: research

Symptom management: the utility of regional cooling for hand-foot syndrome induced by pegylated liposomal doxorubicin in ovarian cancer
ConclusionsOur study indicates that FGS is a safe, simple method with good tolerability. A prospective study is needed for further assessment.
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research

What Causes Flushing?
Discussion Flushing is usually thought of as a benign condition such as blushing, but can be quite irritating if it is frequent or persistent (i.e. menopausal hot flashes) or even pathologic (i.e. malignancy). “Flushing is a subjective and sensation of warmth that is accompanied by reddening of the skin anywhere on the body but favors the face, neck, and upper torso…. Flushing can be broadly divided into episodic or persistent. Episodic flashing is mediated by the release of endogenous vasoactive mediators or medications, while persistent flushing result in a fixed facial erythema with telangiectasias and cyano...
Source: PediatricEducation.org - April 30, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

A Diagnostic Dilemma: Sometimes You ’ ll Never Know
Discussion It can be difficult to consider what is the problem when a health care provider is presented with a group of seemingly disparate signs and symptoms with a history and time course that do not match classic (or commonly atypical) disease presentations. Common things happen commonly, so when symptoms occur without the usual co-occurring symptoms, unusual symptoms or time courses, it can be challenging. The provider must develop a reasonable differential diagnosis and balance how far to go with the evaluation against how much to monitor the patient for new signs or symptoms which can provide new information. Patient...
Source: PediatricEducation.org - March 19, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

A case of neuropathic pain in monoclonal mast cell activation syndrome
We present a patient with neuropathic pain associated with monoclonal mast cell activation syndrome (MMAS) and review the agents used in his treatment.
Source: Annals of Allergy, Asthma and Immunology - February 23, 2018 Category: Allergy & Immunology Authors: Jeannie L. Bay, Kaye E. Sedarsky, Maureen M. Petersen Tags: Letter Source Type: research

In Defense of Morphine (Part 1)
Discussion, we all know why they performed this study, what they expected it to show, and how it will be cited for years to come. It demonstrates an association between morphine and worse outcomes in patients with ST-elevation acute myocardial infarction (STEMI). I don’t know why everyone has been ganging up on poor old morphine for acute coronary syndrome (ACS)—maybe because it’s been beloved by so many for so long—but while I may not be able to empathize with the hardships of being popular, I sympathize with the hate it’s been receiving and hope to offer some exculpation.   How did we get here?...
Source: EMS 12-Lead - February 17, 2018 Category: Cardiology Authors: Vince DiGiulio Tags: Original Articles Vince DiGiulio Source Type: research

The influence of individualized treatment on the quality of life (QoL) in 100 patients with Hereditary Angioedema (HAE C1-INH)
Hereditary angioedema due to C1-inhibitor deficiency (HAE-C1-INH) is a rare autosomal dominant inherited disease. The recurrent symptoms are subcutaneous edema and colic-like abdominal pain. Laryngeal edema is rare, but life-threatening if untreated. One of the major goals in the management of HAE-C1-INH patients is the immediate treatment of attacks which can be achieved by self-infusion /-treatment at home. With the ability to control attacks immediately but with potential mental stress caused by the intravenous self-treatment in contrast to subcutan treatment.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Inmaculada Martinez Saguer, Carmen Escuriola Ettingshausen, Zeynep Gutowski, Richard Linde Source Type: research

A phase 3 trial of mometasone furoate sinus implants for chronic sinusitis with recurrent nasal polyps
ConclusionSignificant improvements over a range of subjective and objective endpoints, including a reduction in the need for sinus surgery by 61%, suggest that MF sinus implants may play an important role in management of recurrent NP.
Source: International Forum of Allergy and Rhinology - January 1, 2018 Category: Allergy & Immunology Authors: Robert C. Kern, J. Pablo Stolovitzky, Stacey L. Silvers, Ameet Singh, Jivianne T. Lee, David M. Yen, Alfred M.C. Iloreta, Francis P.J. Langford, Boris Karanfilov, Keith E. Matheny, James W. Stambaugh, Anna K. Gawlicka, Tags: ORIGINAL ARTICLE Source Type: research

Headaches and facial pain in rhinology.
Abstract "Sinus headache" is a common chief complaint that often leads patients to an otolaryngologist's office. Because facial pain may or may not be sinogenic in origin, the otolaryngologist should be equipped to evaluate and treat or to appropriately refer these patients. Analysis of current data indicates that the majority of patients who present with sinus headaches actually have migraines. Furthermore, the downstream effect of the cytokine cascade initiated in migraine physiology can cause rhinologic symptoms, including rhinorrhea, congestion, and lacrimation, which may also confound diagnosis. Other causes ...
Source: American Journal of Rhinology and Allergy - January 1, 2018 Category: ENT & OMF Authors: Jayawardena ADL, Chandra R Tags: Am J Rhinol Allergy Source Type: research

Intranasal tissue necrosis associated with opioid abuse: Case report and systematic review
ConclusionIntranasal opioid abuse is a prevalent condition associated with chronic pain and tissue necrosis that is clinically concerning for invasive fungal disease. Whereas IFRS must be excluded, even in patients without known immunodeficiency, complete resolution of symptoms can be expected following surgical debridement with cessation of opioid abuse. Laryngoscope, 2017
Source: The Laryngoscope - December 27, 2017 Category: ENT & OMF Authors: Danielle A. Morrison, Sarah K. Wise, John M. DelGaudio, Naweed I. Chowdhury, Joshua M. Levy Tags: Allergy/Rhinology Source Type: research

How Common Is Hereditary Angioedema?
Discussion Angioedema is edema that is non-pitting, self-limited occurring in non-dependent areas usually in an asymmetric distribution usually on the lips, face, hands, feet, genitals and also in the bowel. It usually develops over minutes to hours (often 1-2 hours) with resolution usually within 24-48 hours. Angioedema often occurs with urticaria but 20% of patients may have isolated angioedema. Acute allergic angioedema is often caused by drugs (including antibiotics and non-steroidal anti-inflammatory drugs), foods, infections, insects, various organic substances (i.e. latex, preservatives, formaldehyde, etc.), and oth...
Source: PediatricEducation.org - October 9, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Herpes labialis: An Update.
CONCLUSION: For episodic treatment, oral antiviral agents, such as acyclovir (Zovirax), valacyclovir (Valtrex) and famciclovir (Famvir), are superior to topical antiviral therapy. Valacyclovir and famciclovir have greater oral bioavailability and are better absorbed than acyclovir, require less frequent dosing, but are more expensive and are not approved for children. Topical antiviral agents such as 5% acyclovir cream/ointment (Zovirax) ± hydrocortisone (Xerese), 1% penciclovir (Denavir) cream, and 50 mg Buccal Adhesive Tablet (ABT-50 mg) can also be used for episodic treatment of herpes labialis. These topical agents ar...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - October 5, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research