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Therapy: Pain Management

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Total 331 results found since Jan 2013.

A Prospective, Descriptive Study to Assess the Clinical Benefits of Using Calendula officinalis Hydroglycolic Extract for the Topical Treatment of Diabetic Foot Ulcers.
Authors: Buzzi M, de Freitas F, Winter M Abstract Diabetic foot ulcers (DFUs) have a significant impact on patient quality of life. A prospective, descriptive pilot study was conducted between May 2012 and December 2013 through the dermatology outpatient unit in a Brazilian hospital to evaluate the clinical benefits of using Calendula officinalis hydroglycolic extract in the treatment of DFUs. Patients diagnosed with a stable neuropathic ulcer of >3 months' duration; ranging in size from 0.5-40 cm2; without osteomyelitis, gangrene, bone exposure, cancer, or deep tissue infection; ages 18-90 years; with adequate ...
Source: Ostomy Wound Management - March 16, 2016 Category: Surgery Tags: Ostomy Wound Manage Source Type: research

Pain control following posterior spine fusion: patient-controlled continuous epidural catheter infusion method yields better post-operative analgesia control compared to intravenous patient controlled analgesia method. A retrospective case series
Conclusions Patient-controlled CEA method is as safe as IV-PCA method and is even more effective than that in controlling immediate post-operative pain in patients treated with posterior spinal fusion.
Source: European Spine Journal - March 8, 2016 Category: Orthopaedics Source Type: research

Clinical Uses of Intrathecal Therapy and Its Placement in the Pain Care Algorithm
We describe the appropriate use of intrathecal therapy in the management of severe chronic pain, based on current best practices. Topics addressed here include patient selection, trialing, dosing and titration, adverse event profiles, long‐term management, intrathecal therapy for cancer‐related pain, and the placement of intrathecal therapy in the pain care algorithm. In appropriately selected patients with chronic pain, intrathecal therapy can provide substantial pain relief with improved functioning and quality of life. Successful long‐term management requires ongoing patient monitoring for changes in efficacy and ...
Source: Pain Practice - February 23, 2016 Category: Anesthesiology Authors: Jason E. Pope, Timothy R. Deer, Brian M. Bruel, Steven Falowski Tags: Review Article Source Type: research

Complications related to blood donation: A multicenter study of the prevalence and influencing factors in voluntary blood donation camps in Karnataka, India
Conclusion: We observed 322 complications for every 10,000 donations. Since 27 out of every 10000 experience moderate and severe complication, the readiness to manage complications is crucial. Women donors, young donors, and donors with a lower weight are at a significantly greater risk of experiencing complications, highlighting the need for specific guidelines for the management of higher risk donor groups. Complications varied significantly between various blood banks. Predonation hydration was effective in limiting complications with generalized symptoms. We recommend a robust donor hemovigilance program for voluntary ...
Source: Asian Journal of Transfusion Science - February 1, 2016 Category: Hematology Authors: Rajat Kumar AgarwalSundar PeriyavanRakesh DhanyaLalith G ParmarAmit SedaiKumari AnkitaArpit VaishRitesh SharmaPrabha Gowda Source Type: research

NSAIDs or paracetamol for short-term treatment of mild to moderate knee pain in early osteoarthritis: are they equivalent?
Commentary on: Verkleij SP, Luijsterburg PA, Willemsen SP, et al.. Effectiveness of diclofenac versus paracetamol in knee osteoarthritis: a randomised controlled trial in primary care. Br J Gen Pract 2015;65:e530–7. Context Management of osteoarthritis (OA) in primary care is often pharmacologically dominated with paracetamol and oral non-steroidal anti-inflammatory drugs (NSAIDs) both very commonly used.1 Current evidence-based guidelines recommend both agents, starting with paracetamol. This is because NSAIDs have a serious side effect profile and paracetamol is generally a lot safer (though perhaps not without pro...
Source: Evidence-Based Medicine - January 22, 2016 Category: Internal Medicine Authors: Conaghan, P. G. Tags: Clinical trials (epidemiology), General practice / family medicine, Immunology (including allergy), Pain (neurology), Pain (palliative care), Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Osteoarthritis, Source Type: research

Comparative evaluation of 0.2% glyceryl trinitrate vs. 2% diltiazem ointment in treatment of chronic anal fissure treatment - a randomized trial
Conclusion Both 0.2% GTN and 2% Diltiazem ointment are equally effective in chronic anal fissure treatment in terms of symptomatic pain relief, healing and recurrence, but headache is a troublesome side effect in patients treated with glyceryl trinitrate ointment. When considering medical management of chronic anal fissure, 2% Diltiazem ointment may be preferable as first-line treatment.
Source: Hellenic Journal of Surgery - January 1, 2016 Category: Surgery Source Type: research

No difference in pain, swelling or function with NSAIDs compared with paracetamol for soft tissue injury
Commentary on: Jones P, Dalziel SR, Lamdin R, et al. Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. Cochrane Database Syst Rev 2015;7:CD007789. Implications for practice and research Paracetamol may be the first choice of treatment for soft tissue injuries because of less adverse events and similar efficacy as non-steroidal anti-inflammatory drugs (NSAIDs). Additional randomised controlled trials (RCTs) are required to determine if there is a difference in return to function or adverse effects between non-selective and COX-2 selective NSAIDs versus paracetamol. F...
Source: Evidence-Based Nursing - December 15, 2015 Category: Nursing Authors: van den Bekerom, M. P. J. Tags: Pain management, Immunology (including allergy), Pain (neurology), Pain (palliative care), Pain (anaesthesia), Complementary medicine, Drugs: musculoskeletal and joint diseases, Trauma, Injury Source Type: research

Design, Synthesis and In Vitro Release Studies of Co-drugs for Rheumatoid Arthritis.
Abstract Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammation that may affect many tissues and organs, but principally the synovial joints. The tendency for joint destruction is greatest in the early stages of disease hence current trend is to introduce a disease-modifying anti-rheumatic drug (DMARD) immediately after the diagnosis of RA in a step- up approach which is generally followed by its combination with a corticosteroid or NSAID. DMARD suppresses inflammatory activity over a long time-frame thus improving day to day function, and also prevents, lessens or dela...
Source: Inflammation and Allergy Drug Targets - December 1, 2015 Category: Allergy & Immunology Authors: Kashmira P, Suneela D, Shakuntalah C, Poorvashree J Tags: Inflamm Allergy Drug Targets Source Type: research

Management of adverse reactions to alemtuzumab infusion
In the 2-year, phase 3 CARE-MS studies of alemtuzumab in patients with relapsing-remitting multiple sclerosis, infusion-associated reactions (IARs) were the most common adverse events. Here we report on IARs during 4-year follow-up. Patients who were treatment-naive (CARE-MS I; NCT00530348) or with inadequate efficacy response to prior therapy (CARE-MS II; NCT00548405) received 2 annual courses of alemtuzumab 12 mg, and as-needed retreatment in an extension study (NCT00930553). Patients received methylprednisolone on the first 3 days of each course. IARs were any adverse event occurring between start of infusion and w...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Sharrack, B., Mayer, L., Coles, A., Hartung, H.-P., Havrdova, E., Selmaj, K., Margolin, D., Compston, A. Tags: Immunology (including allergy), Headache (including migraine), Multiple sclerosis, Pain (neurology) Thur 21, Parallel session 5: Therapeutics Source Type: research

FDA panel recommends limited use of Bayer’s Essure until more is known about safety
An FDA advisory panel yesterday recommended that the agency limit the use of Bayer‘s (ETR:BAYN) Essure female sterilization device until more is known about its safety, after thousands of women reported serious health issues they attribute to the nickel-titanium implant. Essure, the only approved permanent birth control device in the U.S., is a small metal coil that is placed in the fallopian tubes via catheter. The FDA approved the device in November 2002. In the near 13 years since then, the health regulator said it had received 5,093 complaints, including those of pain or menstrual irregularities after using th...
Source: Mass Device - September 25, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Food & Drug Administration (FDA) Regulatory/Compliance Women's Health Bayer HealthCare Obstetrics and Gynecology Devices Advisory Panel Source Type: news

The diagnosis and management of acute otitis media: American Academy of Pediatrics Guidelines 2013
Information about THE current guideline In February 2013, the American Academy of Pediatrics (AAP) published a revised clinical guideline on The Diagnosis and Management of Acute Otitis Media in children aged 6 months to 12 years.1 This guideline review summarises this guidance and compares it with UK guidance on acute otitis media (AOM). The AAP guidance is specific to uncomplicated AOM (see box 2) in an otherwise healthy child. The guidance does not apply to children with underlying conditions that may alter the natural course of AOM, for example, the presence of grommets, cleft palate, immune deficiencies and ...
Source: Archives of Disease in Childhood - Education and Practice - July 17, 2015 Category: Pediatrics Authors: Siddiq, S., Grainger, J. Tags: Immunology (including allergy), Drugs: infectious diseases, Otitis, Pain (neurology), Nursing, Child health, Dentistry and oral medicine, Ear, nose and throat/otolaryngology, Guidelines Guideline review Source Type: research

Nasolabial cysts: A systematic review of 311 cases
ConclusionsEndoscopic transnasal marsupialization is a relatively new alternative to intraoral sublabial resection of nasolabial cysts, with similar efficacy. The rates of postoperative swelling, pain, and recurrence are similar in both groups. Laryngoscope, 2015
Source: The Laryngoscope - July 7, 2015 Category: ENT & OMF Authors: Ahmed B. Sheikh, Oliver Y. Chin, Christina H. Fang, James K. Liu, Soly Baredes, Jean Anderson Eloy Tags: Allergy/Rhinology Source Type: research

Long‐term outcomes of powered endoscopic dacryocystorhinostomy in acute dacryocystitis
ConclusionPowered endoscopic DCR is a useful modality in the management acute dacryocystitis, with good outcomes that are maintained over a long duration of time. Level of Evidence4. Laryngoscope, 2015
Source: The Laryngoscope - May 21, 2015 Category: ENT & OMF Authors: Naja Chisty, Manpreet Singh, Mohammad Javed Ali, Milind N. Naik Tags: Allergy/Rhinology Source Type: research

Diet in irritable bowel syndrome
Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder that is characterized by intermittent abdominal pain/discomfort, altered bowel habits and abdominal bloating/distension. This review aimed at presenting the recent developments concerning the role of diet in the pathophysiology and management of IBS. There is no convincing evidence that IBS patients suffer from food allergy/intolerance, and there is no evidence that gluten causes the debated new diagnosis of non-coeliac gluten sensitivity (NCGS). The component in wheat that triggers symptoms in NCGS appears to be the carbohydrates. Patients with N...
Source: Nutrition Journal - April 14, 2015 Category: Nutrition Authors: Magdy El-SalhyDoris Gundersen Source Type: research

Intracranial plasmacytoma with hypoglossal nerve palsy in multiple myeloma
Introduction Isolated hypoglossal nerve palsy (HNP) presents with ipsilateral tongue deviation due to atrophy of the tongue musculature.1 Isolated HNP is rare due to its close proximity to other cranial nerves and long anatomical course. Unilateral lesions usually suggest space-occupying lesions while bilateral involvement is usually due to nerve degeneration or demyelination.2 Plasma cell neoplasms may affect the skull base producing a range of cranial nerve palsies including HNP, with up to 30% of those affected subsequently developing multiple myeloma (MM).3 Prompt recognition of this important differential diagnosis of...
Source: Postgraduate Medical Journal - March 4, 2015 Category: Journals (General) Authors: Sin, W. Y. C., Grant, I. Tags: Journalology, Oesophagus, Immunology (including allergy), Pain (neurology), Chemotherapy, Radiotherapy, Screening (oncology), Radiology, Surgical diagnostic tests, General surgery, Surgical oncology, Transplantation, Ethics Images in medicine Source Type: research