Comparative evaluation of 0.2% glyceryl trinitrate vs. 2% diltiazem ointment in treatment of chronic anal fissure treatment - a randomized trial

Conclusion Both 0.2% GTN and 2% Diltiazem ointment are equally effective in chronic anal fissure treatment in terms of symptomatic pain relief, healing and recurrence, but headache is a troublesome side effect in patients treated with glyceryl trinitrate ointment. When considering medical management of chronic anal fissure, 2% Diltiazem ointment may be preferable as first-line treatment.
Source: Hellenic Journal of Surgery - Category: Surgery Source Type: research