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ASAP < sc > l < /sc > -Arabinose Attenuates Gliadin-Induced Food Allergy via Regulation of Th1/Th2 Balance and Upregulation of Regulatory T Cells in Mice
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.0c07167
Source: Journal of Agricultural and Food Chemistry - March 18, 2021 Category: Food Science Authors: Yu Wang, Juan Sun, Lamei Xue, Jinxin Liu, Chenzhipeng Nie, Mingcong Fan, Haifeng Qian, Duo Zhang, Hao Ying, Yan Li, and Li Wang Source Type: research
Toxicological assessment and food allergy of silk fibroin derived from Bombyx mori cocoons
Food Chem Toxicol. 2021 Mar 12:112117. doi: 10.1016/j.fct.2021.112117. Online ahead of print.ABSTRACTRecent studies have demonstrated silk fibroin's (SF) ability to extend the shelf life of foods by mitigating the hallmarks of spoilage, namely oxidation and dehydration. Due to the potential for this protein to become more widespread, its safety was evaluated comprehensively. First, a bacterial reverse mutation test (Ames test) was conducted in five bacterial strains. Second, an in vivo erythrocyte test was conducted with Sprague Dawley rats at doses up to 1,000mg/kg-bw/day. Third, a range-finder study was conducted with Sp...
Source: Food and Chemical Toxicology - March 16, 2021 Category: Food Science Authors: Sezin Yigit Nadia S Hallaj James L Sugarman Lester C Chong Samantha E Roman Laith M Abu-Taleb Richard E Goodman Philip E Johnson Adam M Behrens Source Type: research
Bayesian Hierarchical Evaluation of Dose-Response for Peanut Allergy in Clinical Trial Screening
Food Chem Toxicol. 2021 Mar 12:112125. doi: 10.1016/j.fct.2021.112125. Online ahead of print.ABSTRACTRisk-based labeling based on the minimal eliciting doses (EDs) in sensitized populations is a potential replacement for precautionary allergen labeling of food allergens. We estimated the dose-response distribution for peanut allergen using data from double-blind placebo-controlled food challenges (DBPCFCs) conducted in the US at multiple sites, testing a population believed to be similar to the general U.S. food allergic population. Our final (placebo-adjusted) dataset included 548 challenges of 481 subjects. Bayesian hier...
Source: Food and Chemical Toxicology - March 16, 2021 Category: Food Science Authors: Lynne T Haber John F Reichard Alice K Henning Peter Dawson R Sharon Chinthrajah Sayantani B Sindher Andrew Long Melissa J Vincent Kari C Nadeau Bruce C Allen Source Type: research
Toxicological assessment and food allergy of silk fibroin derived from Bombyx mori cocoons
Food Chem Toxicol. 2021 Mar 12:112117. doi: 10.1016/j.fct.2021.112117. Online ahead of print.ABSTRACTRecent studies have demonstrated silk fibroin's (SF) ability to extend the shelf life of foods by mitigating the hallmarks of spoilage, namely oxidation and dehydration. Due to the potential for this protein to become more widespread, its safety was evaluated comprehensively. First, a bacterial reverse mutation test (Ames test) was conducted in five bacterial strains. Second, an in vivo erythrocyte test was conducted with Sprague Dawley rats at doses up to 1,000mg/kg-bw/day. Third, a range-finder study was conducted with Sp...
Source: Food and Chemical Toxicology - March 16, 2021 Category: Food Science Authors: Sezin Yigit Nadia S Hallaj James L Sugarman Lester C Chong Samantha E Roman Laith M Abu-Taleb Richard E Goodman Philip E Johnson Adam M Behrens Source Type: research
Bayesian Hierarchical Evaluation of Dose-Response for Peanut Allergy in Clinical Trial Screening
Food Chem Toxicol. 2021 Mar 12:112125. doi: 10.1016/j.fct.2021.112125. Online ahead of print.ABSTRACTRisk-based labeling based on the minimal eliciting doses (EDs) in sensitized populations is a potential replacement for precautionary allergen labeling of food allergens. We estimated the dose-response distribution for peanut allergen using data from double-blind placebo-controlled food challenges (DBPCFCs) conducted in the US at multiple sites, testing a population believed to be similar to the general U.S. food allergic population. Our final (placebo-adjusted) dataset included 548 challenges of 481 subjects. Bayesian hier...
Source: Food and Chemical Toxicology - March 16, 2021 Category: Food Science Authors: Lynne T Haber John F Reichard Alice K Henning Peter Dawson R Sharon Chinthrajah Sayantani B Sindher Andrew Long Melissa J Vincent Kari C Nadeau Bruce C Allen Source Type: research
A Novel Isoallergen Dau c 1.0401 in Carrot: Stability, Allergenicity, and Comparison with Other Isoallergens
ConclusionDau c 1.0401 is a new isoallergen which contributes to the allergenicity of carrots. The absence of immunoreactivity in immobilized assays indicates that IgE binding is impaired when the protein is blotted on a solid phase. Altogether, the results point out that its allergenicity can be reduced upon carrot processing.
Source: Molecular Nutrition and Food Research - March 3, 2021 Category: Food Science Authors: Thessa Jacob,
Andrea Wangorsch,
Lothar Vogel,
Andreas Reuter,
Vera Mahler,
Birgitta M. W öhrl Tags: Research Article Source Type: research
Allergy to walnuts and hazelnuts in atopic dermatitis patients and analysis of sensitization to molecular components
Volume 32, Issue 1, December 2021, Page 105-120 .
Source: Food and Agricultural Immunology - February 28, 2021 Category: Food Science Authors: J. Čelakovská J. Buka č R. Va ňková M. Salavec J. Krejsek C. Andr ýs Source Type: research
Synergistic anti-allergy activity using a combination of Enterococcus faecalis IC-1 and luteolin
Publication date: Available online 18 February 2021Source: Food BioscienceAuthor(s): Lulu Han, Iwao Sakane, Masashi Mizuno
Source: Food Bioscience - February 19, 2021 Category: Food Science Source Type: research
A novel Isoallergen Dau c 1.0401 in Carrot: Stability, Allergenicity and Comparison with Other Isoallergens
ConclusionDau c 1.0401 is a new isoallergen which contributes to the allergenicity of carrots. The absence of immunoreactivity in immobilized assays indicates that IgE binding is impaired when the protein is blotted on a solid phase. Altogether, the results point out that its allergenicity can be reduced upon carrot processing.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - February 6, 2021 Category: Food Science Authors: Thessa Jacob,
Andrea Wangorsch,
Lothar Vogel,
Andreas Reuter,
Vera Mahler,
Birgitta M. W öhrl Tags: Research Article Source Type: research
Front Cover: Suppression of Hippo Pathway by Food Allergen Exacerbates Intestinal Epithelia Instability and Facilitates Hypersensitivity
In this study, both in vivo and in vitro data revealed that the suppression of Hippo pathway by food allergen exacerbates intestinal epithelia instability and facilitates hypersensitivity. TAZ is a crucial protein regulating Hippo ‐mediated food allergy, and depletion of TAZ blocked allergen‐induced epithelial allergic responses. This is reported by Chong Wang, Wanglei lin Yanbo, and Wang Linglin Fu in article2000593.
Source: Molecular Nutrition and Food Research - February 2, 2021 Category: Food Science Authors: Chong Wang,
Wanglei lin,
Yanbo Wang,
Linglin Fu Tags: Front Cover Source Type: research
A novel approach to ameliorate experimental milk allergy based on the oral administration of a short soy cross-reactive peptide
Publication date: 1 June 2021Source: Food Chemistry, Volume 346Author(s): Ángela María Candreva, Paola L. Smaldini, Ana Cauerhff, Silvana Petruccelli, Guillermo H. Docena
Source: Food Chemistry - January 22, 2021 Category: Food Science Source Type: research
Evaluating Potential Risks of Food Allergy of Novel Food Sources Based on Comparison of Proteins Predicted from Genomes and Compared to www.AllergenOnline.org.
Abstract
Potential proteins from three novel food sources (Chlorella variabilis, Galdieria sulphuraria, and Fusarium strain flavolapis) were predicted from genomic sequences and were evaluated for potential risks of allergic cross-reactivity by comparing the predicted amino acid sequences against the allergens in the www.AllergenOnline.org (AOL) database. The preliminary analysis used CODEX Alimentarius limits of >35% identity over 80 amino acids to evaluate the predicted proteins which include many evolutionarily conserved proteins. Regulators might expect clinical serum IgE tests based on identity matches abo...
Source: Food and Chemical Toxicology - December 1, 2020 Category: Food Science Authors: Abdelmoteleb M, Zhang C, Furey B, Kozubal M, Griffiths H, Champeaud M, Goodman RE Tags: Food Chem Toxicol Source Type: research
Suppression of Hippo Pathway by Food Allergen Exacerbates Intestinal Epithelia Instability and Facilitates Hypersensitivity
ConclusionsBoth in vivo and in vitro data demonstrated that the two food allergens suppressed Hippo pathway by downregulating TAZ expression, resulting in intestinal epithelia instability, and finally leading to hypersensitivity reactions. These findings provided potential therapeutic targets and molecular markers for food allergy, and provide dietary guidelines for allergenic individuals.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - November 27, 2020 Category: Food Science Authors: Chong Wang,
Wanglei lin,
Yanbo Wang,
Linglin Fu Tags: Research Article Source Type: research
Food and food products associated with food allergy and food intolerance – An overview
Publication date: December 2020Source: Food Research International, Volume 138, Part BAuthor(s): Janani Muthukumar, Pavidharshini Selvasekaran, Monica Lokanadham, Ramalingam Chidambaram
Source: Food Research International - October 25, 2020 Category: Food Science Source Type: research
