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NIAID Is Dedicated To Saving The Lives Of People With TB
Originally published on niaid.nih.gov Statement of Christine F. Sizemore, PhD., Richard Hafner, M.D., and Anthony S. Fauci, M.D. National Institute of Allergy and Infectious DiseasesNational Institutes of Health Tuberculosis (TB) is one of the world’s most devastating infectious diseases. March 24th marks the day in 1882 when German microbiologist Robert Koch announced he had discovered Mycobacterium tuberculosis, the bacterium that causes this ancient scourge. Today, in recognition of World TB Day, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH)...
Source: Healthy Living - The Huffington Post - March 24, 2017 Category: Consumer Health News Source Type: news

One Little Girl Beat The Deadliest Form Of Tuberculosis. She Is Very Lucky.
WASHINGTON ― When Baltimore resident Arjun kisses his 6-year-old daughter’s forehead, it’s not always just a sign of affection. His daughter, Sujata, is onto him. “Is that a temperature kiss?” she asks. Arjun compulsively checks his little girl’s temperature for a reason. Sujata is the survivor of the “first well-described case” of extensively drug-resistant tuberculosis in a young child in the U.S., according to her physicians. Tuberculosis is the world’s biggest killer among infectious diseases, and extensively drug-resistant tuberculosis ― or XDR-TB, which is re...
Source: Science - The Huffington Post - March 24, 2017 Category: Science Source Type: news

NIH-funded Antibacterial Resistance Leadership Group details progress, challenges
(NIH/National Institute of Allergy and Infectious Diseases) The National Institute of Allergy and Infectious Diseases provided funding to establish an Antibacterial Resistance Leadership Group to develop, prioritize and implement a clinical research agenda to address the growing public health threat of antibiotic resistance. A new series of articles appearing in the March 15 issue of the journal Clinical Infectious Diseases details the group's progress and outlines its ongoing and future efforts.
Source: EurekAlert! - Infectious and Emerging Diseases - March 9, 2017 Category: Infectious Diseases Source Type: news

AMA1-RON2 Complex-Based Vaccine Against Malaria
This technology relates to a malaria vaccine composed of a protein complex of Apical Membrane Antigen (AMA1) and rhoptry neck protein 2 (RON2) with an adjuvant. AMA1 is a crucial component of thePlasmodium invasion machinery and is a leading candidate for antimalarial vaccine development. AMA1-based vaccines have shown ability to block red cell invasion inin vitro assays, but protection has so far not translated toin vivo human infections. NIAID investigators have demonstrated that interaction between AMA1 and RON2 (or peptide thereof) is essential for malaria parasites to successfully enter human red blood cells (RBCs). V...
Source: NIH OTT Licensing Opportunities - March 9, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research

Clinical benefits of treatment with SQ house dust mite sublingual tablet in house dust mite allergic rhinitis
This article is protected by copyright. All rights reserved.
Source: Allergy - March 7, 2017 Category: Allergy & Immunology Authors: Kristian Funding Andersen, Pascal Demoly, J örg Kleine‐Tebbe, Dorte Rehm Tags: Brief Communication Source Type: research

Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study
Publication date: Available online 16 February 2017 Source:The Lancet Respiratory Medicine Author(s): Jason R Andrews, Elisa Nemes, Michele Tameris, Bernard S Landry, Hassan Mahomed, J Bruce McClain, Helen A Fletcher, Willem A Hanekom, Robin Wood, Helen McShane, Thomas J Scriba, Mark Hatherill Background The value of quantitative interferon-γ release assay results for predicting progression from Mycobacterium tuberculosis infection to active disease is unknown. We aimed to investigate the relation between QuantiFERON-TB Gold In-Tube (QFT) conversion interferon-γ values and risk of subsequent active tuberculosis disease ...
Source: The Lancet Respiratory Medicine - February 15, 2017 Category: Respiratory Medicine Source Type: research

India Scraps Funding Ties With Gates Foundation on Immunisation India Scraps Funding Ties With Gates Foundation on Immunisation
A group backed by the Bill and Melinda Gates Foundation that works on India ' s immunization programs will now be funded by the health ministry, a government official said, a move in part prompted by fears foreign donors could influence policy making.Reuters Health Information
Source: Medscape Allergy Headlines - February 9, 2017 Category: Allergy & Immunology Tags: Public Health & Prevention News Source Type: news

Unveiling of HIV dynamics among transgender women: a respondent-driven sampling study in Rio de Janeiro, Brazil
Publication date: Available online 8 February 2017 Source:The Lancet HIV Author(s): Beatriz Grinsztejn, Emilia M Jalil, Laylla Monteiro, Luciane Velasque, Ronaldo I Moreira, Ana Cristina F Garcia, Cristiane V Castro, Alícia Krüger, Paula M Luz, Albert Y Liu, Willi McFarland, Susan Buchbinder, Valdilea G Veloso, Erin C Wilson Background The burden of HIV in transgender women (transwomen) in Brazil remains unknown. We aimed to estimate HIV prevalence among transwomen in Rio de Janeiro and to identify predictors of newly diagnosed HIV infections. Methods We recruited transwomen from Rio de Janeiro, Brazil, by respondent-dr...
Source: The Lancet HIV - February 7, 2017 Category: Infectious Diseases Source Type: research

Causes and outcomes of sepsis in southeast Asia: a multinational multicentre cross-sectional study
This study was registered with ClinicalTrials.gov, number NCT02157259. Findings From Dec 16, 2013, to Dec 14, 2015, 4736 patients were screened and 1578 patients (763 children and 815 adults) were enrolled. Dengue viruses (n=122 [8%]), Leptospira spp (n=95 [6%]), rickettsial pathogens (n=96 [6%]), Escherichia coli (n=76 [5%]), and influenza viruses (n=65 [4%]) were commonly identified in both age groups; whereas Plasmodium spp (n=12 [1%]) and Salmonella enterica serovar Typhi (n=3 [0·2%]) were rarely observed. Emerging pathogens identified included hantaviruses (n=28 [2%]), non-typhoidal Salmonella spp (n=21 [1%]), Strept...
Source: The Lancet Global Health - January 16, 2017 Category: Global & Universal Source Type: research

Erratum
In the article entitled “Immunodominance in allergic T-cell reactivity to Japanese cedar in different geographic cohorts” (Ann Allergy Asthma Immunol 2016;117:680-689), acknowledgment of funding sources was inadvertently omitted from the article. Funding for the article was provided in part by ALK-Abello A/S (Horsholm, Denmark) and with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under grant number U19 AI100275.
Source: Annals of Allergy, Asthma and Immunology - January 15, 2017 Category: Allergy & Immunology Tags: Erratum Source Type: research

Effect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per μL: secondary outcome results from a randomised controlled trial
This study is registered with ClinicalTrials.gov, number NCT00867048. Findings Patients were recruited from April 15, 2009, to Dec 23, 2013. The data cutoff for follow-up was May 26, 2015. Of 4685 HIV-positive people enrolled, 120 had severe bacterial infections (immediate-initiation group n=34, deferred-initiation group n=86; median 2·8 years of follow-up). Immediate ART was associated with a reduced risk of severe bacterial infection compared with deferred ART (hazard ratio [HR] 0·39, 95% CI 0·26–0·57, p<0·0001). In the immediate-initiation group, average neutrophil count over follow-up was 321 cells per μ...
Source: The Lancet HIV - January 4, 2017 Category: Infectious Diseases Source Type: research

5 Ways The Zika Virus Is Here To Stay
Zika virus’ status as a global health threat may officially be over, but the disease’s impact is far from contained.  The World Health Organization decided in November to end its designation of Zika virus as a public health emergency, but that doesn’t mean that Zika virus has disappeared, explained Dr. Carlos Pardo-Villamizar, a clinical neurologist with an expertise in infectious disorders at Johns Hopkins Medicine. Alongside pressing concerns about how to prevent a resurgence of the disease, health care systems in Brazil and other countries that saw births of babies infected with the disease in ute...
Source: Science - The Huffington Post - January 4, 2017 Category: Science Source Type: news

The era of research collaborations: new models for working together
The past two decades have seen the creation of several European collaborations focusing on asthma and chronic obstructive pulmonary disease (COPD). The growth of the collaboration model for research began in the late 1990s with the Framework Programme (FP)-4-funded project on severe asthma, ENFUMOSA (European Network for Understanding Mechanisms of Severe Asthma), a cross-sectional observational study that provided the proof of principle for large collaborations. Soon after, two more in-depth projects were established, focusing on mechanisms and biomarkers of severe asthma and COPD in two longitudinal cohort studies: BIOAI...
Source: European Respiratory Journal - January 2, 2017 Category: Respiratory Medicine Authors: Djukanovic, R., Bruselle, G., Walker, S., Holgate, S. T., Skrgat, S., Kuna, P., Heaney, L. G., Canonica, G. W., Vestbo, J. Tags: Asthma and allergy Editorials Source Type: research