New evidence on sleep ontogeny in adults
Publication date: Available online 18 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Sergio Brasil Tufik, Monica Levy Andersen, Gabriel Natan Pires, Sergio Tufik (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 20, 2019 Category: Respiratory Medicine Source Type: research

Normal polysomnography parameters in healthy adults: a systematic review and meta-analysis
This study is a comprehensive meta-analysis of adult polysomnography parameters scored using recent criteria and establishes normative values adjusted for age and sex.MethodsFor this meta-analysis of adult polysomnography parameters, we searched Scopus for studies of any design published between Jan 1, 2007, and July 31, 2016, that reported polysomnographic parameters scored using recent American Academy of Sleep Medicine criteria (2007 or 2012) collected during an overnight level 1 in-laboratory sleep study in healthy controls. We excluded studies of patients with conditions or subjected to treatments that might affect sl...
Source: The Lancet Respiratory Medicine - April 20, 2019 Category: Respiratory Medicine Source Type: research

An ethics framework and practical guidance for post-trial access to an RSV maternal vaccine
Publication date: Available online 16 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Natalie I Mazur, Louis J Bont, Johannes J M van Delden, Saad B Omer (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 17, 2019 Category: Respiratory Medicine Source Type: research

Tuberculosis in diabetes: insidious and neglected
Publication date: Available online 16 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Ammara Mushtaq (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 17, 2019 Category: Respiratory Medicine Source Type: research

The gender gap in critical care task force participation
Publication date: Available online 15 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Katherine T Janssen, Haley M Urbach, Kealy R Ham, Sandi S Wewerka, Peter B Bach, Colin R Cooke, Sara E Erickson (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 16, 2019 Category: Respiratory Medicine Source Type: research

Early-onset emphysema in a large French-Canadian family: a genetic investigation
Publication date: Available online 15 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Yohan Bossé, Maxime Lamontagne, Nathalie Gaudreault, Christine Racine, Marie-Hélène Levesque, Benjamin M Smith, Dominique Auger, Alisson Clemenceau, Marie-Ève Paré, Louis Laviolette, Victor Tremblay, Bruno Maranda, Mathieu C Morissette, François MaltaisSummaryBackgroundInherited mutations in SERPINA1 coding for the alpha-1 antitrypsin (A1AT) protein is the only well established cause of hereditary emphysema. We aimed to identify the genetic ecause of early-onset emphysema in a five-gen...
Source: The Lancet Respiratory Medicine - April 16, 2019 Category: Respiratory Medicine Source Type: research

Exploring the optimal use of alectinib
Publication date: Available online 15 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Diego Enrico, Christophe Massard, Benjamin Besse (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 16, 2019 Category: Respiratory Medicine Source Type: research

Advances in chronic obstructive pulmonary disease genetics: building the picture one piece at a time
Publication date: Available online 15 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Simonetta Baraldo (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 16, 2019 Category: Respiratory Medicine Source Type: research

Precision medicine in obstructive sleep apnoea
Publication date: Available online 12 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Miguel Angel Martinez-Garcia, Francisco Campos-Rodriguez, Ferrán Barbé, David Gozal, Alvar AgustíSummaryObstructive sleep apnoea (OSA) is a heterogeneous and complex disease; however, diagnosis and management still rely on a simple set of tools and few therapeutic options. Precision medicine has emerged as the next goal for clinical practice, with the objective being to offer individually tailored treatments. Ways of implementing precision medicine in clinical practice have emerged for various respiratory ...
Source: The Lancet Respiratory Medicine - April 14, 2019 Category: Respiratory Medicine Source Type: research

Alectinib versus crizotinib in untreated Asian patients with anaplastic lymphoma kinase-positive non-small-cell lung cancer (ALESIA): a randomised phase 3 study
This study is the first phase 3 randomised trial recruiting only Asian patients to compare alectinib with crizotinib as a first-line treatment for ALK-positive non-small-cell lung cancer with 600 mg of alectinib twice per day. This study assessed consistency of the progression-free survival benefit with the global phase 3 ALEX study.MethodsIn this randomised, open-label, phase 3 study done at 21 investigational sites in China, South Korea, and Thailand, Asian patients, aged 18 years or older, with ALK-positive non-small-cell lung cancer were randomly assigned (2:1) to twice-daily oral alectinib (600 mg) or crizotinib (250 ...
Source: The Lancet Respiratory Medicine - April 11, 2019 Category: Respiratory Medicine Source Type: research

Functional effects of the microbiota in chronic respiratory disease
Publication date: Available online 8 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Kurtis F Budden, Shakti D Shukla, Saima Firdous Rehman, Kate L Bowerman, Simon Keely, Philip Hugenholtz, Darius P H Armstrong-James, Ian M Adcock, Sanjay H Chotirmall, Kian Fan Chung, Philip M HansbroSummaryThe composition of the lung microbiome is increasingly well characterised, with changes in microbial diversity or abundance observed in association with several chronic respiratory diseases such as asthma, cystic fibrosis, bronchiectasis, and chronic obstructive pulmonary disease. However, the precise effects of the microbio...
Source: The Lancet Respiratory Medicine - April 9, 2019 Category: Respiratory Medicine Source Type: research

The true scale of artisanal mining
Publication date: Available online 5 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Talha Khan Burki (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 6, 2019 Category: Respiratory Medicine Source Type: research

Dust to dust
Publication date: Available online 5 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Coreen McGuire (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 6, 2019 Category: Respiratory Medicine Source Type: research

Emergency MDI and spacer packs for asthma and COPD
Publication date: Available online 5 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Duncan Keeley, Martyn R Partridge (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 6, 2019 Category: Respiratory Medicine Source Type: research

An insider view on the World Symposium on Pulmonary Hypertension
Publication date: Available online 4 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Marc Humbert, Nazzareno Galiè, Vallerie V McLaughlin, Lewis J Rubin, Gérald Simonneau (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 5, 2019 Category: Respiratory Medicine Source Type: research

Machine learning molecular classification in IPF: UIP or not UIP, that is the question
Publication date: Available online 1 April 2019Source: The Lancet Respiratory MedicineAuthor(s): Simon Hart (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 2, 2019 Category: Respiratory Medicine Source Type: research

Use of a molecular classifier to identify usual interstitial pneumonia in conventional transbronchial lung biopsy samples: a prospective validation study
We report prospective findings for the clinical validity and utility of this molecular test.MethodsWe prospectively recruited 237 patients for this study from those enrolled in the Bronchial Sample Collection for a Novel Genomic Test (BRAVE) study in 29 US and European sites. Patients were undergoing evaluation for interstitial lung disease and had had samples obtained by clinically indicated surgical or transbronchial biopsy or cryobiopsy for pathology. Histopathological diagnoses were made by experienced pathologists. Available HRCT scans were reviewed centrally. Three to five transbronchial lung biopsy samples were coll...
Source: The Lancet Respiratory Medicine - April 2, 2019 Category: Respiratory Medicine Source Type: research

Can monocytes predict prognosis of idiopathic pulmonary fibrosis?
Publication date: Available online 29 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Michael Kreuter, Toby M Maher (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 31, 2019 Category: Respiratory Medicine Source Type: research

Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study
Publication date: Available online 29 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Madeleine K D Scott, Katie Quinn, Qin Li, Robert Carroll, Hayley Warsinske, Francesco Vallania, Shirley Chen, Mary A Carns, Kathleen Aren, Jiehuan Sun, Kimberly Koloms, Jungwha Lee, Jessika Baral, Jonathan Kropski, Hongyu Zhao, Erica Herzog, Fernando J Martinez, Bethany B Moore, Monique Hinchcliff, Joshua DennySummaryBackgroundThere is an urgent need for biomarkers to better stratify patients with idiopathic pulmonary fibrosis by risk for lung transplantation allocation who have the same clinical presentation. We aimed to inve...
Source: The Lancet Respiratory Medicine - March 31, 2019 Category: Respiratory Medicine Source Type: research

Interstitial lung abnormalities: ignotum per ignotius
Publication date: Available online 29 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Katerina M Antoniou, Vasilios Tzilas, Eirini Vasarmidi, Emmanouil K Symvoulakis, Argyris Tzouvelekis, Demosthenes Bouros (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 31, 2019 Category: Respiratory Medicine Source Type: research

Legionella transmission through cooling towers: towards better control and research of a neglected pathogen
Publication date: Available online 28 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Anne Paschke, Ulrich E Schaible, Wolfgang Hein (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 29, 2019 Category: Respiratory Medicine Source Type: research

A role for psychosocial support in the management of respiratory disorders
Publication date: Available online 28 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Priya Venkatesan (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 29, 2019 Category: Respiratory Medicine Source Type: research

Searching for a chemoimmunotherapy signal in patients with non-small-cell lung cancer and EGFR mutations
Publication date: Available online 25 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Jose M Pacheco, D Ross Camidge (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 27, 2019 Category: Respiratory Medicine Source Type: research

Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial
Publication date: Available online 25 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Martin Reck, Tony S K Mok, Makoto Nishio, Robert M Jotte, Federico Cappuzzo, Francisco Orlandi, Daniil Stroyakovskiy, Naoyuki Nogami, Delvys Rodríguez-Abreu, Denis Moro-Sibilot, Christian A Thomas, Fabrice Barlesi, Gene Finley, Anthony Lee, Shelley Coleman, Yu Deng, Marcin Kowanetz, Geetha Shankar, Wei Lin, Mark A SocinskiSummaryBackgroundThe IMpower150 trial showed significant improvements in progression-free and overall survival with atezolizumab plus bevacizumab plus carboplatin plus paclitaxel (ABCP) versus the stan...
Source: The Lancet Respiratory Medicine - March 27, 2019 Category: Respiratory Medicine Source Type: research

Precision medicine for cell therapy in acute respiratory distress syndrome
Publication date: April 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 4Author(s): Haibo Zhang, Yimin Li, Arthur S S.sky (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 27, 2019 Category: Respiratory Medicine Source Type: research

Precision medicine for cell therapy in acute respiratory distress syndrome – Authors' reply
Publication date: April 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 4Author(s): Michael A Matthay, Hanjing Zhuo, Jeffrey E Gotts, Kathleen D Liu, Carolyn S Calfee (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 27, 2019 Category: Respiratory Medicine Source Type: research

Correction to Lancet Respir Med 2019; 7: 204–06
Publication date: April 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 4Author(s): (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 27, 2019 Category: Respiratory Medicine Source Type: research

Correction to Lancet Respir Med 2018; 6: 545–53
Publication date: April 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 4Author(s): (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 27, 2019 Category: Respiratory Medicine Source Type: research

The microbiome and tuberculosis: state of the art, potential applications, and defining the clinical research agenda
Publication date: Available online 22 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Charissa C Naidoo, Georgina R Nyawo, Benjamin G Wu, Gerhard Walzl, Robin M Warren, Leopoldo N Segal, Grant TheronSummaryThe diverse microbial communities within our bodies produce metabolites that modulate host immune responses. Even the microbiome at distal sites has an important function in respiratory health. However, the clinical importance of the microbiome in tuberculosis, the biggest infectious cause of death worldwide, is only starting to be understood. Here, we critically review research on the microbiome's associatio...
Source: The Lancet Respiratory Medicine - March 24, 2019 Category: Respiratory Medicine Source Type: research

Ventilation before intubation: how to prevent hypoxaemia?
Publication date: Available online 18 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Jonathan D Casey, Matthew W Semler (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 19, 2019 Category: Respiratory Medicine Source Type: research

Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial
Publication date: Available online 18 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Jean-Pierre Frat, Jean-Damien Ricard, Jean-Pierre Quenot, Nicolas Pichon, Alexandre Demoule, Jean-Marie Forel, Jean-Paul Mira, Rémi Coudroy, Guillaume Berquier, Benoit Voisin, Gwenhaël Colin, Bertrand Pons, Pierre Eric Danin, Jérome Devaquet, Gwenael Prat, Raphaël Clere-Jehl, Franck Petitpas, Emmanuel Vivier, Keyvan Razazi, Mai-Anh NaySummaryBackgroundNon-invasive ventilation has never been compared with high-flow oxygen to determine whether it reduces the risk of severe hypoxaemia during intubation. We...
Source: The Lancet Respiratory Medicine - March 19, 2019 Category: Respiratory Medicine Source Type: research

Challenges of chronic obstructive pulmonary disease in rural Nepal
Publication date: Available online 14 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Charlotte E Bolton, Binaya KC, Rajendra Koju, Ian P Hall (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 16, 2019 Category: Respiratory Medicine Source Type: research

Bacterial and viral respiratory tract microbiota and host characteristics in children with lower respiratory tract infections: a matched case-control study
Publication date: Available online 15 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Wing Ho Man, Marlies A van Houten, Marieke E Mérelle, Arine M Vlieger, Mei Ling J N Chu, Nicolaas J G Jansen, Elisabeth A M Sanders, Debby BogaertSummaryBackgroundLower respiratory tract infections (LRTIs) are a leading cause of childhood morbidity and mortality. Potentially pathogenic organisms are present in the respiratory tract in both symptomatic and asymptomatic children, but their presence does not necessarily indicate disease. We aimed to assess the concordance between upper and lower respiratory tract microbiot...
Source: The Lancet Respiratory Medicine - March 16, 2019 Category: Respiratory Medicine Source Type: research

The nasopharyngeal microbiome and LRTIs in infants
Publication date: Available online 15 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Geraint B Rogers (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 16, 2019 Category: Respiratory Medicine Source Type: research

Listening in the quiet zone: will evaluation of small airways pay off?
Publication date: Available online 12 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Carrie Pistenmaa Aaron (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 14, 2019 Category: Respiratory Medicine Source Type: research

Pembrolizumab in patients with advanced non-small-cell lung cancer (KEYNOTE-001): 3-year results from an open-label, phase 1 study
This study is registered at ClinicalTrials.gov, number NCT01295827, and is ongoing.FindingsBetween May 8, 2012 and July 13, 2014, 550 patients (101 treatment naive and 449 previously treated) were enrolled. Median follow-up was 34·5 months at data cutoff (Sept 1, 2016). At 36 months, investigator-assessed objective response according to immune-related response criteria was achieved for 41 of 101 treatment naive patients (41% [95% CI 30·9–50·8]; median duration of response was 16·7 months [95% CI 12·6–not reached]) and 102 of 449 previously treated patients (23% [18·9&nd...
Source: The Lancet Respiratory Medicine - March 14, 2019 Category: Respiratory Medicine Source Type: research

Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study
This study aimed to assess which combination of biomarkers, physiological tests, and imaging markers best measure the presence and extent of SAD in patients with asthma.MethodsIn this baseline assessment of a multinational prospective cohort study (the Assessment of Small Airways Involvement in Asthma [ATLANTIS] study), we recruited participants with and without asthma (defined as Global Initiative for Asthma severity stages 1–5) from general practices, the databases of chest physicians, and advertisements at 29 centres across nine countries (Brazil, China, Germany, Italy, Spain, the Netherlands, the UK, the USA, and...
Source: The Lancet Respiratory Medicine - March 14, 2019 Category: Respiratory Medicine Source Type: research

Immune checkpoint inhibitors in non-small-cell lung cancer: key to long-term survival?
Publication date: Available online 12 March 2019Source: The Lancet Respiratory MedicineAuthor(s): A-MC Dingemans, LEL Hendriks (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 14, 2019 Category: Respiratory Medicine Source Type: research

The world is failing on silicosis
Publication date: Available online 11 March 2019Source: The Lancet Respiratory MedicineAuthor(s): The Lancet Respiratory Medicine (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 12, 2019 Category: Respiratory Medicine Source Type: research

Tobacco control in Jordan
Publication date: Available online 11 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Talha Khan Burki (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 12, 2019 Category: Respiratory Medicine Source Type: research

New guidelines for home oxygen therapy in children
Publication date: Available online 8 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Susan Rahimi (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 9, 2019 Category: Respiratory Medicine Source Type: research

Progress needed in bronchopulmonary dysplasia
Publication date: Available online 1 March 2019Source: The Lancet Respiratory MedicineAuthor(s): Ammara Mushtaq (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 4, 2019 Category: Respiratory Medicine Source Type: research

Towards optimal treatment for latent Mycobacterium tuberculosis infection
Publication date: March 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 3Author(s): Ibrahim Abubakar, Jeremiah Chakaya, Markus Maeurer, Alimuddin Zumla (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 28, 2019 Category: Respiratory Medicine Source Type: research

Spotting the old foe—revisiting the case definition for TB
Publication date: March 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 3Author(s): Rein M G J Houben, Hanif Esmail, Jon C Emery, Louis R Joslyn, C Finn McQuaid, Nicolas A Menzies, Joaquín Sanz, Sourya Shrestha, Richard G White, Chongguang Yang, Frank Cobelens (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 28, 2019 Category: Respiratory Medicine Source Type: research

Screening for tuberculosis: time to move beyond symptoms
Publication date: March 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 3Author(s): Christina Yoon, David W Dowdy, Hanif Esmail, Peter MacPherson, Samuel G Schumacher (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 28, 2019 Category: Respiratory Medicine Source Type: research

The way forward for tuberculosis vaccines
Publication date: March 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 3Author(s): Richard G White, Willem A Hanekom, Johan Vekemans, Rebecca C Harris (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 28, 2019 Category: Respiratory Medicine Source Type: research

Smoking prevalence and chronic diseases in China
Publication date: March 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 3Author(s): Asghar Shah, Jaffer Shah, Naveed Shah, Raida Shah (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 28, 2019 Category: Respiratory Medicine Source Type: research

Our patients and our planet—holistic considerations for inhaler choice
Publication date: March 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 3Author(s): Alexander Wilkinson, Toby Hillman, Nicholas S Hopkinson, Christer Janson, James Smith, Ashley A Woodcock (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 28, 2019 Category: Respiratory Medicine Source Type: research

Correction to Lancet Respir Med 2019; 7: 115–28
Publication date: March 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 3Author(s): (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 28, 2019 Category: Respiratory Medicine Source Type: research

Correction to Lancet Respir Med 2019; 7: 213–26
Publication date: March 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 3Author(s): (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 28, 2019 Category: Respiratory Medicine Source Type: research