Filtered By:
Source: European Respiratory Journal

This page shows you your search results in order of date.

Order by Relevance | Date

Total 2423 results found since Jan 2013.

Severe asthma trajectories in adults: findings from the NORDSTAR cohort
Conclusions Four distinct trajectories of severe asthma were identified illustrating different patterns of progression of asthma severity. This may eventually enable the development of better preventive management strategies in severe asthma.
Source: European Respiratory Journal - September 9, 2023 Category: Respiratory Medicine Authors: von Bülow, A., Hansen, S., Sandin, P., Ernstsson, O., Janson, C., Lehtimäki, L., Kankaanranta, H., Ulrik, C., Aarli, B. B., Geale, K., Tang, S. T., Wolf, M., Backer, V., Hilberg, O., Altraja, A., Backman, H., Ludviksdottir, D., Bjö Tags: Asthma and allergy Original Articles: Asthma and natural history Source Type: research

Simplifying pharmacotherapy for patients with COPD: a viewpoint
Source: European Respiratory Journal - August 17, 2023 Category: Respiratory Medicine Authors: Celli, B., Vestbo, J. Tags: Asthma and allergy Editorials Source Type: research

Revisiting asthma pharmacotherapy: where do we stand and where do we want to go?
Several current guidelines/strategies outline a treatment approach to asthma, which primarily consider the goals of improving lung function and quality of life and reducing symptoms and exacerbations. They suggest a strategy of stepping up or down treatment, depending on the patient's overall current asthma symptom control and future risk of exacerbation. While this stepwise approach is undeniably practical for daily practice, it does not always address the underlying mechanisms of this heterogeneous disease. In the last decade, there have been attempts to improve the treatment of severe asthma, such as the addition of a l...
Source: European Respiratory Journal - August 17, 2023 Category: Respiratory Medicine Authors: Cazzola, M., Page, C. P., Matera, M. G., Rogliani, P., Hanania, N. A. Tags: Asthma and allergy State of the Art Source Type: research

The impact of steroid-sparing biologic therapies on weight loss in obese individuals with severe eosinophilic asthma
Extract Asthma and obesity are prevalent disorders with significant impact on public health. Obesity is a reported risk factor for the development of asthma and is associated with increased exacerbation rates, medication usage and higher symptoms scores in patients with asthma. It should therefore be addressed and treated as an important asthma related comorbidity [1]. Oral corticosteroids (OCS) are widely prescribed for asthma exacerbations and for chronic management of severe asthma despite well-known adverse side-effects, including weight gain. Biologic therapies for severe asthma reduce exacerbation rates and the anti-...
Source: European Respiratory Journal - August 3, 2023 Category: Respiratory Medicine Authors: Nanzer, A. M., Taylor, V., Hearn, A. P., Kavanagh, J. E., Patrick, T., Green, L., Thomson, L., Lam, J., Fernandes, M., Roxas, C., d'Ancona, G., Kent, B. D., Dhariwal, J., Jackson, D. J. Tags: Asthma and allergy Research Letters Source Type: research

Nasal airway microRNA profiling of infants with severe bronchiolitis and risk of childhood asthma: a multicentre prospective study
Conclusion In a multicentre cohort of infants with severe bronchiolitis, we identified nasal miRNAs during illness that were associated with major asthma-related clinical features, immune response, and risk of asthma development.
Source: European Respiratory Journal - August 3, 2023 Category: Respiratory Medicine Authors: Zhu, Z., Freishtat, R. J., Harmon, B., Hahn, A., Teach, S. J., Perez-Losada, M., Hasegawa, K., Camargo, C. A., on behalf of the MARC-35 Investigators Tags: Asthma and allergy Original Articles: Asthma and biomarkers Source Type: research

Associations of improved air quality with lung function growth from childhood to adulthood: the BAMSE study
Conclusions Long-term reduction of air pollution is associated with positive lung function development from childhood to young adulthood.
Source: European Respiratory Journal - May 5, 2023 Category: Respiratory Medicine Authors: Yu, Z., Merid, S. K., Bellander, T., Bergström, A., Eneroth, K., Georgelis, A., Hallberg, J., Kull, I., Ljungman, P., Klevebro, S., Stafoggia, M., Wang, G., Pershagen, G., Gruzieva, O., Melen, E. Tags: Epidemiology, occupational and environmental lung disease Original Articles: Environment and air pollution Source Type: research

Minimal clinically important difference for impulse oscillometry in adults with asthma
Conclusions This study provides MCIDs for IOS-derived measures in adult patients with asthma and emphasises that small airway function is a distinguished end-point beyond the conventional measure of FEV1.
Source: European Respiratory Journal - May 5, 2023 Category: Respiratory Medicine Authors: Abdo, M., Kirsten, A.-M., von Mutius, E., Kopp, M., Hansen, G., Rabe, K. F., Watz, H., Trinkmann, F., Bahmer, T., on behalf of the ALLIANCE study group Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)
Conclusions This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma.
Source: European Respiratory Journal - April 3, 2023 Category: Respiratory Medicine Authors: Khaleva, E., Rattu, A., Brightling, C., Bush, A., Bossios, A., Bourdin, A., Chung, K. F., Chaudhuri, R., Coleman, C., Dahlen, S.-E., Djukanovic, R., Deschildre, A., Fleming, L., Fowler, S. J., Gupta, A., Hamelmann, E., Hashimoto, S., Hedlin, G., Koppelman Tags: Asthma and allergy Reviews Source Type: research

Identifying and appraising outcome measures for severe asthma: a systematic review
Conclusions Only two outcome measures had robust developmental data for severe asthma. This review informed development of core outcome measures sets for severe asthma.
Source: European Respiratory Journal - April 3, 2023 Category: Respiratory Medicine Authors: Rattu, A., Khaleva, E., Brightling, C., Dahlen, S.-E., Bossios, A., Fleming, L., Chung, K. F., Melen, E., Djukanovic, R., Chaudhuri, R., Exley, A., Koppelman, G. H., Bourdin, A., Rusconi, F., Porsbjerg, C., Coleman, C., Williams, C., Nielsen, H., Davin, E Tags: Asthma and allergy Reviews Source Type: research

Development of a tool to detect small airways dysfunction in asthma clinical practice
Conclusions If access to respiratory tests is limited (e.g. primary care in many countries), patients with SAD could reasonably well be identified by asking about wheezing at rest and a few patient characteristics. In (advanced) hospital settings patients with SAD could be identified with considerably higher accuracy using spirometry and oscillometry.
Source: European Respiratory Journal - March 30, 2023 Category: Respiratory Medicine Authors: Kocks, J., van der Molen, T., Voorham, J., Baldi, S., van den Berge, M., Brightling, C., Fabbri, L. M., Kraft, M., Nicolini, G., Papi, A., Rabe, K. F., Siddiqui, S., Singh, D., Vonk, J., Leving, M., Flokstra-de Blok, B. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Dupilumab increases aspirin tolerance in NSAID-exacerbated respiratory disease
Conclusion In this study, 57% of N-ERD patients tolerated higher doses of aspirin under dupilumab therapy.
Source: European Respiratory Journal - March 16, 2023 Category: Respiratory Medicine Authors: Schneider, S., Poglitsch, K., Morgenstern, C., Quint, T., Gangl, K., Sinz, C., Bartosik, T., Campion, N. J., Liu, D. T., Landegger, L. D., Tu, A., Stanek, V., Rocha-Hasler, M., Bangert, C., Eckl-Dorna, J. Tags: Asthma and allergy Original Articles: Asthma and allergy Source Type: research

Inhaled anti-TSLP antibody fragment, ecleralimab, blocks responses to allergen in mild asthma
Conclusion Ecleralimab significantly attenuated allergen-induced bronchoconstriction and airway inflammation, and was safe in subjects with mild atopic asthma.
Source: European Respiratory Journal - March 9, 2023 Category: Respiratory Medicine Authors: Gauvreau, G. M., Hohlfeld, J. M., FitzGerald, J. M., Boulet, L.-P., Cockcroft, D. W., Davis, B. E., Korn, S., Kornmann, O., Leigh, R., Mayers, I., Watz, H., Grant, S. S., Jain, M., Cabanski, M., Pertel, P. E., Jones, I., Lecot, J. R., Cao, H., O'Byrne, P. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Rhinitis phenotypes and multimorbidities in the general population: the CONSTANCES cohort
Conclusions In this large population-based cohort, 40% reported current rhinitis, with a lower prevalence of moderate-to-severe rhinitis than in clinical practice. For the first time in a general adult population, we showed that AR and NAR alone or in combination with asthma or in combination with asthma and conjunctivitis are different phenotypes. These results provide new insights on how best to manage rhinitis and its multimorbidities.
Source: European Respiratory Journal - February 9, 2023 Category: Respiratory Medicine Authors: Savoure, M., Bousquet, J., Leynaert, B., Renuy, A., Siroux, V., Goldberg, M., Zins, M., Jacquemin, B., Nadif, R. Tags: Asthma and allergy Original Research Articles Source Type: research

Narrative review to capture patients perceptions and opinions about non-response and response to biological therapy for severe asthma
Conclusions Definitions of non-response and response need to be patient-centred, yet there is a complete lack of qualitative research focused on this topic. By combining relevant published and grey literature we have provided a description of adult patients’ perceptions of response to biological therapy in severe asthma. We now need to understand the views of children and adolescents with severe asthma and their carers, and diverse patient experiences in real-world settings.
Source: European Respiratory Journal - January 19, 2023 Category: Respiratory Medicine Authors: Coleman, C., Khaleva, E., Rattu, A., Frankemölle, B., Nielsen, H., Roberts, G., Williams, C., on behalf of the 3TR Respiratory Work Package Tags: Asthma and allergy Reviews Source Type: research

Living without eosinophils: evidence from mouse and man
The enduring view of eosinophils, as immune effector cells whose primary function is host defence against infection by helminths and other microbial pathogens, sets the stage for a fundamental question regarding the safety of therapeutic eosinophil depletion. If eosinophils are significantly reduced or altogether depleted in an effort to alleviate the negative effects of tissue eosinophilia and eosinophilic inflammation in conditions such as asthma, COPD, chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome, would these patients become susceptible to infecti...
Source: European Respiratory Journal - January 12, 2023 Category: Respiratory Medicine Authors: Jackson, D. J., Pavord, I. D. Tags: Asthma and allergy Reviews Source Type: research