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Source: European Respiratory Journal

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Total 2423 results found since Jan 2013.

Association between Th2 biomarker levels and efficacy of house dust mite sublingual allergy immunotherapy in adults with allergic asthma
Many individuals with asthma have an underlying allergy, and house dust mites (HDMs) are a common trigger. Biomarkers of the type 2 (Th2) immune response are associated with severity of allergic asthma.The aim of this study was to investigate the association between baseline values of Th2 biomarkers and efficacy of sublingual allergy immunotherapy (SLIT)-tablet treatment.MITRA (Clinicaltrialsregister.eu 2010-018621-19) was a phase III, randomized, double-blind, placebo-controlled trial of HDM SLIT-tablets in 834 adults with HDM allergic asthma. A post-hoc analysis of the MITRA study population was performed to evaluate the...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Hoof, I., Witten, M., Stranzl, T., Brand, S., Shamji, M. H., Bateman, E. D., Bleecker, E. R., Andersen, P. S. Tags: Airway pharmacology and treatment Source Type: research

Long-Acting Beta Agonist Asthma Pharmacogenetic Loci Identified in Two Multi-Racial Asthma Clinical Trials
Conclusions: GWAS identified plausible pharmacogenetic loci requiring replication including FOXP1 whose deletion in airway epithelium results in airway hyperresponsiveness (Li J Clin Invest 2016), an asthma epigenetic locus (TBC1D1, Hoang Eur Respir J 2020), and albuterol response locus in African descent minorities (PLCB1, Mak Am J Respir Crit Care Med 2018).
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Ortega, V., Daya, M., Ampleford, E., Hawkins, G., Moore, W., Peters, S., Barnes, K., Bleecker, E., Meyers, D. Tags: Airway pharmacology and treatment Source Type: research

Effects of anti-IL-17 on inflammation and oxidative stress in an ASTHMA-COPD overlap syndrome (ACO) model
Conclusions: Inhibition of IL-17 contributes to control of Th2/Th17 inflammation and oxidative stress in an ASTHMA-COPD overlap syndrome (ACO) model.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: D. N. Camargo, L., Martins, N., M. D. Almeida, F., Lourenco, J., Bezerra, S., M.D. Santos, T., Fukuzaki, S., D. T. Q. D. S. Lopes, F., M. Martin, M., A. Leick, E., F. Righetti, R., M. Prado, C., D. F. L. C.Tiberio, I. Tags: Allergy and immunology Source Type: research

Identifying eosinophil subsets in a mouse model of pollutant-aggravated allergic asthma
In conclusion, both rEOS and iEOS were significantly increased in the lungs of mice exposed to HDM+DEP.Funding: Fund for Scientific Research Flanders (G041819N; G0G2318N), Ghent University (BOF19-GOA-008; AAP position) and Chiesi Chair on Environmental factors in asthma.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Bontinck, A., De Volder, J., Roffel, M. P., Brusselle, G. G., Joos, G. F., Maes, T. Tags: Allergy and immunology Source Type: research

The effect of IL-33 and IL-25 on the rhinovirus-induced susceptibility of the lung vascular endothelium to SARS-CoV-2, MERS and 229E coronaviral infections
Conclusion: By the regulation of coronaviral entry receptors on the lung vascular endothelium, rhinovirus, IL-33 and IL-25 may determine the susceptibility to coronaviral 229E, MERS and SARS-CoV-1/2 infection.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Chalubinski, M., Gulbas, I., Gawrysiak, M., Szewczyk, R., Gajewski, A., Kowalski, M. L. Tags: Allergy and immunology Source Type: research

Traffic-related air pollution induces mitochondrial oxidative stress and transgenerational mitochondrial dysfunction
Conclusion: Maternal PM exposure induced transgenerational hyper-responsiveness and is highly associated with mitochondrial dysfunction. Mitochondrial dysfunction is driven by oxidative stress.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: WANG, B., Chan, Y., Anwer, A., Saad, S., Chen, H., Oliver, B. Tags: Allergy and immunology Source Type: research

Mast cell chymase induce functional and morphological alterations in bronchial epithelial cells
Conclusion: We show that MC chymase can induced cell migration, morphological alterations and impaired barrier properties in BECs. Thus, our data implies that intraepithelial MC release of chymase may play a critical role in airway remodelling and disruption of epithelial function in patients with increased numbers of MCTC.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Berlin, F., Mogren, S., Uller, L., Andersson, C. Tags: Allergy and immunology Source Type: research

Thymic stromal lymphopoietin (TSLP) as a local biomarker of hypertrophic changes in the synonasal mucosa in children with atopic bronchial asthma (BA) and allergic rhinitis (AR)
Conclusion: Hypertrophic changes in the nasal mucosa are accompanied by a statistically significant increase of TSLP content in the nasal secret in children with atopic BA and AR, which allows to consider this biomarker as a potential non-invasive predictor of pathological airway remodeling in patients with chronic allergic airway inflammation.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Klimanov, I. A., Soodaeva, S., Eruslankin, N., Ovsyannikov, D., Frolov, P., Eliseeva, T., Krasilnikova, S., Glukhova, M., Nikitina, L. Tags: Allergy and immunology Source Type: research

Hypertrophic and polyposis synonasal mucosa (SM) changes in children with atopic bronchial asthma (BA) and allergic rhinitis (AR)
Conclusions: Children with hypertrophic and polyposis changes in SM showed a statistically significantly higher level of total serum IgA compared with children without SM hypertrophy. Apparently, BA and AR patients with hypertrophic SM changes have a unique systemic immunological profile that requires serious study.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Klimanov, I. A., Eruslankin1, N., Vagina, A., Eliseeva, T., Krasilnikova, S., Bulgakova, V., Balabolkin, I., Glukhova, M., Nikitina, L., Soodaeva, S. Tags: Allergy and immunology Source Type: research

Interleukin-10 expressing regulatory B cells are decreased in blood of smokers and COPD patients
Conclusion: We demonstrate decreased numbers of IL10+ memory Breg cells in blood of smokers and COPD patients ex vivo, and decreased percentages and impaired Breg function, upon CSE exposure in vitro. Further research is needed to elucidate whether Breg cell numbers are decreased and/or impaired in lung tissue of smokers or COPD patients in vivo and whether this contributes to COPD pathogenesis.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Jacobs, M., Verschraegen, S., Salhi, B., Brusselle, G., Bracke, K. Tags: Allergy and immunology Source Type: research

IL-33 may augment the effect of rhinovirus HRV16 on the inflammatory activity of human lung vascular endothelium - possible implication for asthma exacerbations
Human rhinovirus (HRV) may cause severe exacerbations of asthma, which is accompanied by increased airway IL-33 concentrations. The aim of the study was to analyze the effect of IL-33 on the HRV-induced inflammatory response by the lung vascular endothelium.Human pulmonary microvascular endothelial cells (HMVEC-L) were exposed to HRV-16 alone or in the presence of IL-33. Number of HRV-16 copies in HMVEC-L, cytokines, chemokines and growth factors mRNA expression were assessed in real-time PCR. Protein concentrations were assessed in BioPlex.HRV16 strongly increased the release of plenty of inflammatory cytokines, including...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Gajewski, A., Gawrysiak, M., Szewczyk, R., Kowalski, M. L., Chałubinski, M. Tags: Allergy and immunology Source Type: research

Respiratory syncytial-virus induced cytokine production from leukocytes is impaired in severe asthma
Conclusion: The impaired activation of circulating leukocytes in response to acute RSV infections may explain the increased susceptibility to RSV in asthma and could be influenced by the severity of type2 inflammation.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Jamal Jameel, K., Yanik, S., Bülthoff, E., Rohde, S., Weidinger, D., Yusuf, F., Kronsbein, J., Tenbusch, M., Knobloch, J. Tags: Allergy and immunology Source Type: research

Different paterns of autoAbs in asthma-COPD overlap cogort
The high heterogeneity of bronchial asthma (BA) and COPD endotypes and the lack of effective tools for early prognosis of its further progression and overlap (ACO) still represent the priority tasks in respiratory medicine. We have evaluated autoreactivity profiles in patients with chronic immune-mediated respiratory diseases: BA, COPD and their overlap ACO (155 patients in total), using modified quantitative ELISA for detection of IgE and IgG4-ABs to commercial tissue antigens of epithelial keratin, type III and VI collagens, myosin and elastin (Sigma USA), conjugates of monoclonal anti-IgE or anti-IgG4 Abs(Polygnost, Rus...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Konishcheva, A., Gervazieva, V., Osipova, G., Ospelnikova, T., Fomina, D. Tags: Allergy and immunology Source Type: research

Interferon-dependant and immune cell-based mechanisms of antiviral resistance of the human lung vascular endothelium infected with rhinovirus HRV16
Conclusions: HRV16 may activate intracellular interferon-dependent and immune cell-based mechanisms of antiviral resistance in HMVEC-L, which suggests the lung endothelium as an orchestrator of antiviral immune response in rhinoviral asthma exacerbations. NCN 2017/25/B/NZ5/01575; Student Grants of the Medical University of Lodz 564/1-000-00/564-20-041
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Gawrysiak, M., Gajewski, A., Szewczyk, R., Kobierecki, M., Szymanski, M., Gulbas, I., Likonska, A., Michlewska, S., Kowalski, M. L., Chałubinski, M. Tags: Allergy and immunology Source Type: research

LSC - 2021 - Mesenchymal stromal cells reduce house dust mite induced allergic airway inflammation in a humanised MIF expressing mouse model
This study sought to elucidate the influence that MIF licensing has on human MSC cytoprotection and immune modulation in vitro. Moreover, the effect of MIF on MSCs therapeutic efficacy in vivo was investigated using a clinically relevant acute house dust mite (HDM) (Dermatophagoides pteronyssinus) model of allergic airway inflammation in humanised MIF mice. MIF pre-stimulation enhanced MSC promotion of wound healing in airway epithelial cells in a VEGF dependent manner. Periodic acid-Schiff and Masson’s Trichrome staining showed that intranasal HDM challenge induced severe mucus production and collagen depositio...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Ian, H., Dunbar, H., Donnelly, S., English, K. Tags: Allergy and immunology Source Type: research