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Source: European Respiratory Journal

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Total 2423 results found since Jan 2013.

Swiss Severe Asthma Registry (SSAR)- Good asthma control and high number of exacerbations. How does this fit?
Discussion: Despite rather good asthma control, the number of reported exacerbations is high, the findings evokes questions for further analyses.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Jaun, F., Capponi, J., Jochmann, A., Pavlov, N., Kern, L., Widmer, S., Clarenbach, C., Sievi, N., Steurer-Stey, C., Duchna, H.-W., Rothe, T., Dinic, M., Oberhänsli, C., Gianella, P., Paronitti Lovera, M., Charbonnier, F., Salamin, M., Bridevaux, P Tags: Monitoring airway disease Source Type: research

Biomarkers for the management of severe asthma: a survey
Conclusions: A close collaboration between Allergists and Pulmonologists is pivotal to recognize the importance of biomarkers in the diagnosis, phenotyping and monitoring of SA.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Micheletto, C., Antonicelli, L., Cecchi, L., Menzella, F., Vaghi, A. Tags: Monitoring airway disease Source Type: research

Airway hyperresponsiveness in adult patients with and without allergies
Conclusion: Unlike men, AHR cases increase significantly in women without allergies after the age of 50, possibly due to hormonal changes. The highest number of AHR is found in young men with allergies, which decreases with age.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Strazda, G., Jurka, N., Madaja, O., Taivans, I. Tags: Monitoring airway disease Source Type: research

Impact of asthma-associated genetic polymorphisms on the efficacy of house dust mite sublingual allergy immunotherapy in adults with allergic asthma
Allergy to house dust mites (HDM) is a common cause of allergic asthma and can be effectively treated with allergy immunotherapy (AIT). Specific single-nucleotide polymorphisms (SNPs) have been associated with asthma, and specifically for the 17q12-21 locus, this association has been shown to be modifiable by environmental factors.The aim of this study was to test whether asthma-associated SNPs have an impact on the response to AIT.MITRA (Clinicaltrialsregister.eu 2010-018621-19) was a phase III, randomized, double-blind, placebo-controlled trial of HDM sublingual immunotherapy (SLIT)-tablets in adults with HDM allergic as...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Hoof, I., Bonnelykke, K., Witten, M., Stranzl, T., Li, X., Meyers, D. A., Bleecker, E. R., Andersen, P. S. Tags: Airway pharmacology and treatment Source Type: research

Effect of bronchial thermoplasty on histopathological parameters in distinct asthma endotypes/phenotypes
Conclusions: BT is associated with decreased ASM, epithelial cell regeneration and increased expression of HSPs in the epithelium. Histopathological effects appear to be distinct in different endotypes/phenotypes indicating that the beneficial effects of BT are achieved by diverse molecular targets associated with asthma endotypes/phenotypes.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Papakonstantinou, E., Koletsa, T., Zhou, L., Fang, L., Roth, M., Karakioulaki, M., Savic, S., Grize, L., Tamm, M., Stolz, D. Tags: Airway pharmacology and treatment Source Type: research

Caregiver burden in paediatric asthma and preschool wheeze and the role of asthma education
Conclusions: Caring for children with PSW and paediatric asthma has both economic and QoL impacts. Asthma education for the caregiver may help reduce burden, but further research is needed.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Lu, E., Boccaletti, S., Keeley, T., Richards, A. Tags: Paediatric asthma and allergy Source Type: research

Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers
Conclusion: Mitochondria act as a key player in BSM cell proliferation in severe preschool wheezers and could thus represent a potential target to treat BSM remodeling at early stage of the disease.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Beaufils, F., Esteves, P., Enaud, R., Germande, O., Celle, A., Marthan, R., Trian, T., Fayon, M., Berger, P. Tags: Paediatric asthma and allergy Source Type: research

Three years follow up: relationship of maternal depression and anxiety with ever-wheezing
In conclusion, prenatal depression and anxiety was not related to ever-wheezing during the first three years of life.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Yilmaz, O., Yasar, A., Ocalan, M., Ay, P., Alkin, T., Hasdemir, S., Yuksel, H. Tags: Paediatric asthma and allergy Source Type: research

Severity scores published for acute wheeze in preschool children: a systematic review
Conclusion: Our systematic review identified 89 severity scores used to assess acute wheeze in preschool children. Few are validated, some are unfeasible, and overlap is significant. One validated severity score should be used routinely, to improve research utility.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Wilkinson, E., Bedson, W., Mcnamara, P., Hawcutt, D. Tags: Paediatric asthma and allergy Source Type: research

How does the Canadian Acute Respiratory Illness and Flu Scale relate to other scales in paediatric asthma exacerbations?
Conclusions: CARIFS and ADS scores correlated well as a disease severity measure during the recovery period in children with acute asthma. Although the CARIFS questionnaire takes longer to complete, it reflects different aspects to acute asthma severity and QoL.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Teoh, L., Chatfield, M., Acworth, J., Mccallum, G., Chang, A. Tags: Paediatric asthma and allergy Source Type: research

Identification of two distinct microbial enterophenotypes in children with moderate-to-severe asthma: results from the SysPharmPediA study
Conclusion: In our study of children with moderate-to-severe asthma, two distinct enterophenotypes correlating with clinical characteristics are present. Further research should assess if signatures in the gut microbiome could become a suitable precision medicine approach for diagnostics and treatment of asthma.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Abdel-Aziz, M. I., Neerincx, A. H., Vijverberg, S. J. H., Hashimoto, S., Gorenjak, M., Toncheva, A. A., Kheiroddin, P., Harner, S., Brandstetter, S., Wolff, C., Sardon Prado, O., Elosegui, P. C., Murua, J. K., Pino-Yanes, M., Potocnik, U., Kabesch, M., Kr Tags: Paediatric asthma and allergy Source Type: research

Severe asthma in children: shall we carry out systematic bronchoalveolar lavage?
This study aims at deciphering if a systematic BAL during a flexible bronchoscopy procedure could improve phenotyping severe asthma. Secondary objectives were to evaluate BAL impact on asthma control and on flexible bronchoscopy morbidity.Patients and methods: The study was held in two departments of Armand Trousseau University Hospital in Paris, France. Children who underwent a flexible bronchoscopy for severe asthma exploration were retrospectively included between April 2017 and September 2019.Results: A total of 203 children were included, 107 had a BAL and 96 did not. BAL fluid cell count showed no abnormality in most...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Ben Tkhayat, R., Just, J., Nathan, N. Tags: Paediatric asthma and allergy Source Type: research

Occupational exposure as a predictor of asthma exacerbation - a multicenter multivariate logistical analysis
Conclusion: More than one third of patients had uncontrolled asthma. One of the strongest predictors for exacerbation is occupational exposure.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Mihaicuta, S., Udrescu, L., Tiotiu, A., Nadasan, V., Frent, S. M. Tags: Occupational and environmental health Source Type: research

HBD-2 mutations are associated with childhood asthma and prophylactic hBD-2 application prevents asthma in mice
Conclusions: Variations in hBD-2 coding genes associate with increased asthma and allergy risk, while early hBD-2 administration hinders atopic asthma symptoms in mice. Further research is needed to evaluate if and how hBD-2 is involved in the protective farm effect against asthma and allergy.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Borchers, N., Santos-Valente, E., Toncheva, A. A., Wehkamp, J., Franke, A., Gaertner, V. D., Nordkild, P., Genuneit, J., Jensen, B. A. H., Kabesch, M. Tags: Paediatric lung cell and molecular biology Source Type: research

Correlation between lactate dehydrogenase and therapeutic strategy in Covid-19 pneumonia
Conclusions: LDH seems to be related to severity of Covid-19 pneumonia and to the type of therapeutic strategy. Moreover could guide physicians in the choice of respiratory support such as non-invasive ventilation.[1] Li X et al. J Allergy Clin Immunol. 2020 Jul;10.1016/j.jaci.2020.04.006.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Cianci, R., Capitelli, L., Buonincontro, M., Donizzetti, R., Cuomo, D., Prisco, A., Squillante, F., Bocchino, V. Tags: Noninvasive ventilatory support Source Type: research