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Source: European Respiratory Journal
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Total 2423 results found since Jan 2013.
Clinico-demographic, radiological and immunological profile of allergic bronchopulmonary aspergillosis in a tertiary care institute of east India.
Conclusion: There was no significant association between lung function abnormalities and eosinophil count. ABPA-S was the most common finding among ABPA patients. High eosinophil count is associated with high incidence of bronchiectasis and hyper attenuated mucus (HAM) although severity of bronchiectasis is not directly related to higher peripheral eosinophil count. There may be some correlation between peripheral eosinophil count and total IgE but no significant correlation with aspergillus specific IgE.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Shankar, M., Ejazi, A., Chaubey, S., Kumar, D. Tags: 05.03 - Allergy and immunology Source Type: research
Three clinical phenotypes of COPD with each a characteristic immunological profile
Conclusion: Cluster analysis differentiated COPD in three clinical phenotypes with each a characteristic immunological profile, which may have relevance for development of targeted therapy strategies.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: van Zelst, C., In'T Veen, J., De Bruijn, M., Van Nimwegen, M., Van Der Ploeg, E., Krabbendam, L., Van Uden, D., Stadhouders, R., Hendriks, R., Braunstahl, G. Tags: 05.03 - Allergy and immunology Source Type: research
Forced Oscillation Technique (FOT) and spirometry in school aged children with stable asthma
Conclusion: Despite the strong correlation noted between the Rrs5, FEV1, and FEV1/FVC in children with well-defined asthma, there were no similar relationships in children where asthma diagnosis was less certain. This suggests that the two techniques may reflect different aspects of the pathophysiological changes in childhood asthma.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: AlRaimi, A., Devani, P., Alshlowi, M., Beardsmore, C., Gaillard, E. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Dupilumab treatment increases transitional B-cells (regulatory B-cells) in severe asthma
Conclusion: Treatment of patients with severe asthma with Dupilumab is associated with an increase in transitional (regulatory) B cells and a decrease in total IgE.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Lommatzsch, M., Dost, M., Jaishankar, N., Weise, M., Stoll, P., Virchow, J. C., Bratke, K. Tags: 05.03 - Allergy and immunology Source Type: research
Predictors of suboptimal asthma control and of asthma attacks differ: the Swiss Paediatric Airway Cohort (SPAC)
Conclusion: Predictors of suboptimal asthma control differ from those of asthma attacks. Future prediction scores and preventive efforts should differentiate these two asthma outcomes.Funding: SNSF:320030_182628 and SLA:2019-03_641670
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Ardura-Garcia, C., Mallet, M. C., Berger, D. O., Pedersen, E. S. L., Hoyler, K., Jochmann, A., Kuhn, A., Moeller, A., Regamey, N., Singer, F., Kuehni, C. E. Tags: 07.06 - Paediatric respiratory epidemiology Source Type: research
Type 2 biomarker expression according to age of asthma onset: an analysis of the German severe asthma registry (GAN)
Conclusion: Severe adult-onset asthma is characterised by a stronger expression of type 2 biomarkers than severe early-onset asthma.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Lommatzsch, M., Taube, C., Hamelmann, E., Milger-Kneidinger, K., Skowasch, D., Jandl, M., Schmitz, F. S., Koerner-Rettberg, C., Idzko, M., Buhl, R., Korn, S. Tags: 05.03 - Allergy and immunology Source Type: research
Does Omalizumab lead to sustained improvement in Asthma Control?
Conclusion: Omalizumab improved asthma control in some patients, but many still remained sub optimally controlled. Other variables are likely to influence asthma control.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Gregson, E., Tang, A., Brookman, S., Tarr, J., Amin, A., Shenoy, A., Kansra, S., Murray, C., Gupta, A. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Is the measurement of particles in exhaled air feasible and useful in children with suspected asthma?
Conclusion: PExA was feasible in more than half of those aged nine and over. Although numbers were small, there was no significant differences in any PExA variables between the three cohorts.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Healy, L., Al-Huda, F., Barrett, E., Willmore, L., Tudge, R., Kerry, G., Murray, C. S., Simpson, A., Fowler, S., Drake, S., Wang, R. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Insilico study of COVID-19 ORF1ab protein allergenicity
Conclusions: According to our data, ORF1ab protein of COVID-19 was potentially allergenic. Hypersensitivity reactions to some SARS-CoV-2 vaccines reported by various studies may be partly due to ORF1ab protein allergenicity. Meanwhile ORF1ab protein being a valuable source of conserved epitopes is suitable to make efficient protein vaccines for control of many SARS-CoV-2 variants. For preparation of safe and effective anti- SARS-CoV-2 vaccines from ORF1ab protein, recognition and elimination of its allergenic epitope (s) is necessary. Altogether immunization with an allergenically engineered ORF1ab protein might have poten...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Hajighasemi, F., Shirkavand, A. Tags: 05.03 - Allergy and immunology Source Type: research
Soluble epoxide hydrolase inhibition alleviates inflammation in cigarette smoke-induced experimental COPD irrespective of dietary fat content
Conclusion: Both amount and composition of dietary fats impact disease features in COPD. Inhibition of sEH reduced airway inflammation and may prove useful as a therapeutic strategy.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Rehman, S. F., Budden, K. F., Quaranta, A., Fuchs, D., Shukla, S. D., Brown, A., Alemao, C., Balachandra, L., Gomez, H., Kumar, V., Idrees, S., Horvat, J., Wood, L. G., Wheelock, C., Hansbro, P. M. Tags: 05.03 - Allergy and immunology Source Type: research
Role of sex and puberty on respiratory outcomes
Conclusion: Girls have a lower risk of wheezing from birth until age 13ys than boys. At school-age, no sex-change in wheezing/asthma prevalence was found during puberty. In addition, girls and boys with a greater puberty maturation had a higher lung function.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Attanasi, M., Mian, A., Van Meel, E. R., Blaauwendraad, S. M., Jaddoe, V. W., Duijts, L. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Secondary adrenal insufficiency with long-term inhaled corticosteroids therapy in asthmatic children
Conclusion: In this study, the prevalence of secondary adrenal insufficiency with long-term ICS therapy was low, and it was not associated with ICS dosage, duration, and asthma control.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Shambhu, L., Kumar, P., Goyal, J., Vyas, V., Singh, K. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Detection of structural airway changes on computed tomography in paediatric severe asthma
Conclusion: Bronchiectasis and airway wall thickening is frequently observed on CTs of children with SA. SAD is related to airway wall thickening.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: van den Bosch, W., Lv, Q., Andrinopoulou, E., Janssens, H., Ciet, P., Tiddens, H. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Impact of COVID-19 related alterations in circulating respiratory viruses on children and adult patients with recurrent wheeze and asthma
Conclusion: COVID-19 related measures caused a reduction and re-emerge of respiratory virus infections, which influenced the course of disease in preschool children with recurrent wheeze, but not in older children and adults with asthma.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Peck, A., Maison, N., Hose, A., Omony, J., Schaub, B., Grychtol, R., Dittrich, A., Nitsche, C., Foth, S., Weckmann, M., Abdo, M., Bahmer, T., Rabe, K. F., Renz, H., Hansen, G., Kopp, M. V., Von Mutius, E. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Benralizumab leads to sustained asthma control improvement after 1 year in real-life severe asthmatics.
Benralizumab is a monoclonal antibody used in the treatment of severe eosinophilic asthmatics. Our own previous real-life study has shown rapid clinical improvements after already the first dose of benralizumab (Renner et al. Allergy. 2020 Dec).The primary aim of this real-life study is to investigate if these rapid improvements are sustained at 12 months.We retrospectively analysed asthma control in all patients who had received benralizumab at our asthma clinic for at least 12 months.38 patients received benralizumab for at least 12 months and 9 patients for at least 24 months. Asthma control, measured with the asthma co...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Renner, A., Marth, K., Patocka, K., Idzko, M., Pohl, W. Tags: 05.01 - Airway pharmacology and treatment Source Type: research
