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Source: European Respiratory Journal
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Total 2423 results found since Jan 2013.
Association of blood trihalomethane concentrations with asthma in US adolescents: nationally representative cross-sectional study
Conclusions
Exposure to THMs is associated with a higher risk of asthma in adolescents, particularly among those exposed to tobacco smoke.
Source: European Respiratory Journal - May 26, 2022 Category: Respiratory Medicine Authors: Sun, Y., Xia, P.-F., Xie, J., Mustieles, V., Zhang, Y., Wang, Y.-X., Messerlian, C. Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Short-acting {beta}2-agonist prescriptions are associated with poor clinical outcomes of asthma: the multi-country, cross-sectional SABINA III study
Conclusions
This study indicates an association between high SABA prescriptions and poor clinical outcomes across a broad range of countries, healthcare settings and asthma severities, providing support for initiatives to improve asthma morbidity by reducing SABA overreliance.
Source: European Respiratory Journal - May 5, 2022 Category: Respiratory Medicine Authors: Bateman, E. D., Price, D. B., Wang, H.-C., Khattab, A., Schonffeldt, P., Catanzariti, A., van der Valk, R. J. P., Beekman, M. J. H. I. Tags: Asthma and allergy Original Articles: Asthma Source Type: research
A randomised trial of prednisolone versus prednisolone and itraconazole in acute-stage allergic bronchopulmonary aspergillosis complicating asthma
Conclusions
There was a trend towards a decline in ABPA exacerbations at 1 year with the prednisolone–itraconazole combination versus prednisolone monotherapy. A three-arm trial comparing itraconazole and prednisolone monotherapies with their combination, preferably in a multicentric design, is required to define the best treatment strategy for acute-stage ABPA.
Source: European Respiratory Journal - April 28, 2022 Category: Respiratory Medicine Authors: Agarwal, R., Muthu, V., Sehgal, I. S., Dhooria, S., Prasad, K. T., Garg, M., Aggarwal, A. N., Chakrabarti, A. Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Asthma and COVID-19 risk: a systematic review and meta-analysis
Background
Individual case series and cohort studies have reported conflicting results in people with asthma on the vulnerability to and risk of mortality from coronavirus disease 2019 (COVID-19).
Research question
Are people with asthma at a higher risk of being infected or hospitalised or poorer clinical outcomes from COVID-19?
Methods
A systematic review and meta-analysis based on five main databases including the World Health Organization COVID-19 database between 1 December 2019 and 11 July 2021 on studies with a control (non-asthma) group was conducted. Prevalence and risk ratios were pooled using Sidik–Jonkm...
Source: European Respiratory Journal - March 31, 2022 Category: Respiratory Medicine Authors: Sunjaya, A. P., Allida, S. M., Di Tanna, G. L., Jenkins, C. R. Tags: Asthma and allergy, Respiratory infections and tuberculosis Original Articles: Asthma and infection Source Type: research
Anti-IL5 mepolizumab minimally influences residual blood eosinophils in severe asthma
We report that restriction of IL5 availability did not elicit any detectable transcriptional response in steady-state residual eosinophils in mepolizumab-treated patients or IL5-deficient mice, and influenced only a handful of genes in their response to IL33. Together, these results support the notion that treatment with IL5 neutralising antibodies spares a pool of circulating residual eosinophils largely resembling those of healthy individuals.
Source: European Respiratory Journal - March 17, 2022 Category: Respiratory Medicine Authors: Van Hulst, G., Jorssen, J., Jacobs, N., Henket, M., Louis, R., Schleich, F., Bureau, F., Desmet, C. J. Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Novel mechanisms of action contributing to benralizumab's potent anti-eosinophilic activity
Conclusions
Our data provide deeper insights into the timely appearance of events leading to benralizumab-induced eosinophil apoptosis and suggest that additional mechanisms may contribute to the potent anti-eosinophilic activity of benralizumab in vivo. Importantly, afucosylation of benralizumab strongly enhanced its potency for all mechanisms investigated.
Source: European Respiratory Journal - March 3, 2022 Category: Respiratory Medicine Authors: Dagher, R., Kumar, V., Copenhaver, A. M., Gallagher, S., Ghaedi, M., Boyd, J., Newbold, P., Humbles, A. A., Kolbeck, R. Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Obesity, tidal volume, and pulmonary deposition of fine particulate matter in children with asthma
Conclusions
Obese children with asthma breathe at higher tidal volumes that may increase the efficiency of PM2.5 deposition in the lung. This finding may partially explain why obese children with asthma exhibit greater sensitivity to air pollution.
Source: European Respiratory Journal - March 3, 2022 Category: Respiratory Medicine Authors: Afshar-Mohajer, N., Wu, T. D., Shade, R., Brigham, E., Woo, H., Wood, M., Koehl, R., Koehler, K., Kirkness, J., Hansel, N. N., Ramchandran, G., McCormack, M. C. Tags: Asthma and allergy, Paediatric pulmonology Original Articles: Asthma and paediatrics Source Type: research
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation
Conclusions
The plasma proteomic panel revealed previously unexplored yet potentially useful Type-2-independent biomarkers and validated several proteins with established involvement in the pathophysiology of SA.
Source: European Respiratory Journal - February 17, 2022 Category: Respiratory Medicine Authors: Sparreman Mikus, M., Kolmert, J., Andersson, L. I., Östling, J., Knowles, R. G., Gomez, C., Ericsson, M., Thörngren, J.-O., Emami Khoonsari, P., Dahlen, B., Kupczyk, M., De Meulder, B., Auffray, C., Bakke, P. S., Beghe, B., Bel, E. H., Car Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Prenatal tobacco exposure and risk of asthma and allergy outcomes in childhood
Conclusion
Prenatal tobacco exposure was associated with asthma dependent on 17q12-21 genotype and with exacerbations, lung function and bronchial responsiveness, but not with any allergy-related outcomes. This suggests that tobacco exposure in utero leads to adverse lung developmental/structural effects rather than susceptibility to develop allergy and type 2 inflammation.
Source: European Respiratory Journal - February 17, 2022 Category: Respiratory Medicine Authors: Sunde, R. B., Thorsen, J., Pedersen, C.-E. T., Stokholm, J., Bonnelykke, K., Chawes, B., Bisgaard, H. Tags: Asthma and allergy, Paediatric pulmonology Original Articles: Asthma and paediatrics Source Type: research
The quest for biomarkers in asthma: challenging the T2 versus non-T2 paradigm
The diversity in pathophysiological, immunological and clinical patterns seen in asthma patients was the key driver for a wealth of biomarker studies during the past decades. Early on, asthma was divided into allergic and non-allergic disease. It was the use of cluster analysis approaches that further increased our understanding of the variety of clinical asthma phenotypes. Several variables were identified to be important to classify patients into clusters, such as the patients’ age of onset, body mass index (BMI), allergy status and sputum eosinophil levels [1, 2]. On a cellular level, four phenotypes based on the ...
Source: European Respiratory Journal - February 17, 2022 Category: Respiratory Medicine Authors: Seys, S. F., Long, M. B. Tags: Editorials Source Type: research
Glucocorticoid toxicity reduction with mepolizumab using the Glucocorticoid Toxicity Index
Conclusion
Mepolizumab resulted in substantial oral glucocorticoid reduction, but this did not correlate with reduction in oral glucocorticoid toxicity, which varies widely at the individual patient level. Oral glucocorticoid reduction is not a comprehensive measure of response to mepolizumab.
Source: European Respiratory Journal - January 20, 2022 Category: Respiratory Medicine Authors: McDowell, P. J., Stone, J. H., Zhang, Y., Honeyford, K., Dunn, L., Logan, R. J., McGarvey, L. P. A., Butler, C. A., Heaney, L. G. Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Stopping versus continuing long-term mepolizumab treatment in severe eosinophilic asthma (COMET study)
Conclusion
Patients who stopped mepolizumab had an increase in exacerbations and reduced asthma control versus those who continued.
Source: European Respiratory Journal - January 6, 2022 Category: Respiratory Medicine Authors: Moore, W. C., Kornmann, O., Humbert, M., Poirier, C., Bel, E. H., Kaneko, N., Smith, S. G., Martin, N., Gilson, M. J., Price, R. G., Bradford, E. S., Liu, M. C. Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Evaluation of bronchial wall thickness in asthma using magnetic resonance imaging
Conclusions
We have demonstrated that MRI-UTE is an accurate and reliable radiation-free method to assess bronchial wall dimensions in asthma, with enough spatial resolution to differentiate severe from non-severe asthma.
Source: European Respiratory Journal - December 31, 2021 Category: Respiratory Medicine Authors: Benlala, I., Dournes, G., Girodet, P.-O., Benkert, T., Laurent, F., Berger, P. Tags: Lung imaging, Asthma and allergy Original Articles: Asthma and imaging Source Type: research
Long-term modulation of airway remodelling in severe asthma following bronchial thermoplasty
Conclusions
Bronchial thermoplasty primarily affects airway smooth muscle and nerves with the effects still present at 12 months post-treatment.
Source: European Respiratory Journal - December 31, 2021 Category: Respiratory Medicine Authors: Jendzjowsky, N., Laing, A., Malig, M., Matyas, J., de Heuvel, E., Dumonceaux, C., Dumoulin, E., Tremblay, A., Leigh, R., Chee, A., Kelly, M. M. Tags: Asthma and allergy Original Articles: Asthma Source Type: research
The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM)
Conclusions
Inhibiting TSLP signalling with tezepelumab reduced the proportion of patients with AHR and decreased eosinophilic inflammation in BAL and airway tissue.
Source: European Respiratory Journal - December 31, 2021 Category: Respiratory Medicine Authors: Sverrild, A., Hansen, S., Hvidtfeldt, M., Clausson, C.-M., Cozzolino, O., Cerps, S., Uller, L., Backer, V., Erjefält, J., Porsbjerg, C. Tags: Asthma and allergy Original Articles: Asthma Source Type: research