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Source: European Respiratory Journal

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Total 2423 results found since Jan 2013.

Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma
Conclusions We report SNPs in/near a zinc finger gene as novel sex-differential loci for atopy-related markers with opposite effect directions in females and males. A potential role for ZNF33B should be studied further as an important driver of sex-divergent features of atopy in childhood asthma.
Source: European Respiratory Journal - January 6, 2023 Category: Respiratory Medicine Authors: Lee, S., Prokopenko, D., Kelly, R. S., Lutz, S., Ann Lasky-Su, J., Cho, M. H., Laurie, C., Celedon, J. C., Lange, C., Weiss, S. T., Hecker, J., DeMeo, D. L. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Adrenal function recovery after durable oral corticosteroid sparing with benralizumab in the PONENTE study
Conclusions Most patients successfully maintained maximal OCS reduction while achieving improved asthma control with few exacerbations and maintaining or recovering adrenal function.
Source: European Respiratory Journal - December 22, 2022 Category: Respiratory Medicine Authors: Menzies-Gow, A., Gurnell, M., Heaney, L. G., Corren, J., Bel, E. H., Maspero, J., Harrison, T., Jackson, D. J., Price, D., Lugogo, N., Kreindler, J., Burden, A., de Giorgio-Miller, A., Faison, S., Padilla, K., Martin, U. J., Garcia Gil, E., the PONENTE St Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Increasing physical activity in severe asthma: a systematic review and meta-analysis
Conclusion While there is some evidence supporting the effectiveness of interventions in improving physical activity in adults with severe asthma, higher-quality, large-scale studies of longer duration are needed to determine the optimal intervention.
Source: European Respiratory Journal - December 15, 2022 Category: Respiratory Medicine Authors: McLoughlin, R. F., Clark, V. L., Urroz, P. D., Gibson, P. G., McDonald, V. M. Tags: Asthma and allergy Reviews Source Type: research

Benefits of specialist severe asthma management: demographic and geographic disparities
Conclusions Specialist assessment and management is associated with substantially improved patient outcomes, which are broadly consistent across demographic groups and are not restricted to those receiving biologic therapy. Significant variation exists between hospitals, which requires further investigation.
Source: European Respiratory Journal - December 15, 2022 Category: Respiratory Medicine Authors: Redmond, C., Heaney, L. G., Chaudhuri, R., Jackson, D. J., Menzies-Gow, A., Pfeffer, P., Busby, J., on behalf of the UK Severe Asthma Registry Tags: Asthma and allergy Original Articles: Asthma Source Type: research

An observational study to determine the relationship between cough frequency and markers of inflammation in severe asthma
Conclusions In patients with low biomarkers of T2 inflammation, cough frequency measurements were not elevated, suggesting that the mechanism for cough in asthma is underlying T2 eosinophilic inflammation and the logical first step for treating cough in asthma may be to achieve adequate suppression of T2 inflammation with currently available therapies.
Source: European Respiratory Journal - December 8, 2022 Category: Respiratory Medicine Authors: Holmes, J., McGarvey, L. P. A., Birring, S. S., Fletcher, H., Heaney, L. G. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Innate immunity plays an important role during NTHI and RV sequential infection
Conclusion: NTHI infection suppressed innate epithelial cell immunity, which enhances susceptibility to RV infection in vitro. The antiviral immunomodulatory role of AZM in airway epithelium was identified.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Long, Y., Morgan, S., Klenerman, P., Hinks, T. Tags: 05.03 - Allergy and immunology Source Type: research

Viral co-detection in severe bronchiolitis and lung function, allergic sensitization and asthma prevalence in school-aged children
Conclusions: The prevalence of asthma at 7-9 years after bronchiolitis was significantly higher in single-HRV or viral coinfection patients that in single-RSV ones. Single-HRV-bronchiolitis was independently associated with lower lung function at school-age.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Gonzalez-German, M. F., Ruiz-Gonzalez, S., Alcolea, S., Pozo, F., Casas, I., Calvo, C., Garcia-Garcia, M. L. Tags: 07.02 - Paediatric asthma and allergy Source Type: research

How pediatrician manage asthma in tertiary care hospitals of Multan, Pakistan- A cross sectional study.
Conclusions: The management of asthma in children lacks the precision. This is far from the evidence based best standard practices. There is a need to provide knowledge, training and logistics to the staff to accomplish the goal.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Mustafa, G. Tags: 07.02 - Paediatric asthma and allergy Source Type: research

Screening and verification of differentially expressed genes for airway remodeling in asthma
Conclusion: The expression of CTSK may related to the airway remodeling of asthma by up-regulating the TGF-β1 expression in BECs.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Qin, L., Liu, C., Wu, M., Yao, Y. Tags: 05.03 - Allergy and immunology Source Type: research

Airway autoantibodies are determinants of asthma severity
Conclusion We report 55% of moderate–severe asthmatic patients to have airway autoreactivity that persists despite anti-inflammatory treatment and is associated with exacerbations.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Salter, B., Zhao, N., Son, K., Tan, N. S., Dvorkin-Gheva, A., Radford, K., LaVigne, N., Huang, C., Kjarsgaard, M., Li, Q.-Z., Tselios, K., Lim, H. F., Khalidi, N., Nair, P., Mukherjee, M. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Bronchodilator reversibility in patients with severe asthma included in the GAN registry.
Conclusion: The majority of patients had negative BDR test and this was associated with lower FeNO levels and history of GERD and EGPA.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Milger-Kneidinger, K., Skowasch, D., Hamelmann, E., Mümmler, C., Idzko, M., Taube, C., Holtdirk, A., Timmerman, H., Buhl, R., Korn, S. Tags: 05.03 - Allergy and immunology Source Type: research

Nurses specialized through higher education in asthma, allergy and COPD. Experiences from a Swedish perspective - A winning concept for the clinic
Conclusion: Advanced education after bachelor’s degree has benefits both for the patient and for the society.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Stridsman, C., Zakrisson, A., Sterner, T. Tags: 09.03 - Nurses Source Type: research

The impact of the Mediterranean diet on rhinitis prevalence
Conclusions: Higher adherence to MD seems to be associated with higher prevalence of rhinitis
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Gonzalez Barcala, F., Acevedo-Prado, A., Seoane-Pillado, M., Lopez-Silvarrey, A., Pertega, S., Salgado, F., Nieto-Fontarigo, J. J., San-Jose-Gonzalez, M., Sanchez-Lastres, J., Sampedro, M., Perez-Castro, T., Garnelo, L., Bamonde, L. Tags: 07.02 - Paediatric asthma and allergy Source Type: research

G-CSF drives pathophysiology of RV-induced allergic asthma exacerbations by potentiating neutrophilic inflammation and ILC2 function
Conclusions G-CSF acts as an instigator of pathophysiology in the context of viral exacerbations of allergic asthma, owing to its capacity to potentiate both neutrophilic and type 2 inflammation. Antibodies targeting G-CSF receptor have completed phase I trials and could represent a new therapeutic strategy for asthma exacerbations.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Bruno, N., Singanayagam, A., Farne, H. A., Aniscenko, J., Glanville, N., Pyle, C. J., Patel, D. F., Johnston, S. L., Snelgrove, R. J. Tags: 05.03 - Allergy and immunology Source Type: research

Distinct metabolic reprogramming of airway epithelium in asthma in response to infection with rhinovirus
Conclusions: Rhinovirus infection in asthmatics leads to less pronounced mitochondrial respiration may suggest less efficient antiviral response. In contrast, enhanced glycolysis may support viral replication in those patients. Only healthy controls actively suppress energy production at later infection stage may indicate resolution of inflammation.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Huang, M., Ding, M., Radzikowska, U., Rodriguez-Coira, J., Stocker, N., Tan, G., Heider, A., Johnston, S., A. Akdis, C., Sokolowska, M. Tags: 05.03 - Allergy and immunology Source Type: research