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Source: European Respiratory Journal
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Total 2423 results found since Jan 2013.
Differences in COVID-19-triggered pediatric asthma exacerbations across variant waves
Conclusions: The omicron variant is more likely to trigger pediatric asthma exacerbations than prior variants, supporting the need for ongoing surveillance of children with asthma who develop COVID-19.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Gaietto, K., Snyder, O., Bergum, N., Dicicco, L. A., Rauenswinter, S., Iagnemma, J., Wolfson, D., Kazmerski, T., Forno, E. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Multidisciplinary checklist approach for the 'severe phenotype: Asthma with Nasal Polyps
Asthma with chronic rhinosinusitis with nasal polyps (CRSwNP) associates with higher burden and more difficult treatment.Aim: To propose an evidence-based data checklist for a coordinated management of these patients.A multidisciplinary team of ENT physicians, allergologists, pneumologists and hospital pharmacist aimed to develop a checklist for the assessment of patients, based on the diagnostic definition, and the control and severity criteria establish in guidelines such GINA, ARIA, EPOS, and international consensus on biologic therapies for CRSwNP and Asthma from EUFOREA and from EAACI, and a multidisciplinary consensu...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Castillo Vizuete, J. A., Armengot, M., Delgado, J., Gil, M., Colas, C., Plasencia, I., Cisneros, C. Tags: 05.03 - Allergy and immunology Source Type: research
Study Of The Correlation Between rs242941 polymorphism in CRHR1 Gene WithThe Responsiveness of Inhaled Corticosteroid Therapy in Children with Asthma
Conclusion: No link between rs242941 polymorphism on CRHR1 gene with corticosteroid response levels has been established; further studies on large sample sizes are needed in a long time.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Nguyen-Bich, H., Nguyen-Ngoc-Quynh, L., Le-Thi-Minh, H., Duong-Quy, S. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Transcriptomic analysis of cellular senescence signatures in severe asthma
Conclusions: Cellular senescence may be involved in the pathophysiology of severe asthma, particularly in patients with comorbid nasal polyps. Further studies are warranted to validate the causal relationships.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Song, W., Zounemat-Kermani, N., Guo, Y., Adcock, I., Chung, K. F. Tags: 05.03 - Allergy and immunology Source Type: research
Post-bronchodilator 1-FEV1/FEV3 as a measure of small airway dysfunction in childhood asthma
In preschool children, forced expiratory volume in 3 seconds (FEV3) has been suggested to estimate forced vital capacity with reasonable accuracy. The latter fraction of forced exhalation – exhalation after one second – could be more sensitive to detect early airway obstruction in asthma. We hypothesized that the ratio of the terminal expiration volume to FEV3 (1-FEV1/FEV3) would be a good reflection of airflow limitation and aimed to determine the clinical usefulness of post-bronchodilator 1-FEV1/FEV3 in childhood asthma.We utilized a retrospective observational cohort of children who underwent spirometry and ...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Roh, Y., Kim, H., Jung, J. H., Park, M., Kim, J. D., Kim, M. J., Kim, Y. H., Sohn, M. H., Kim, K. W., Kim, S. Y. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Translating host-respiratory virus genetic susceptibility signals to candidate casual genes and pathways to provide therapeutic opportunities
Conclusions: Identification of candidate causal genes helps give a mechanistic understanding of important host-virus mechanisms and may serve as target for novel therapeutics or drug repurposing to treat viral infection.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Shrees, C., Rakkar, K., Portelli, M., Hannan, N., Tarr, A., Sayers, I. Tags: 03.01 - Molecular pathology and functional genomics Source Type: research
Inflammatory phenotypes and comorbidities in mild-to-moderate COPD
Conclusion: Comorbidities among patients with mild-to-moderate COPD are associated with distinct inflammatory phenotypes. This confirms that the association between comorbidities and systemic inflammation in COPD is more complex than assumed until now.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Soumagne, T., Hue, S., Dalphin, J., Degano, B. Tags: 05.03 - Allergy and immunology Source Type: research
Follow-up of severe asthmatic children during COVID-19 pandemic: A comparative analysis
Conclusion: Virtual team clinics and electronic ACT at home were introduced easily and effectively during pandemic to manage SA children. Follow-up of almost all patients could be ensured.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Pelaez, G., Giubergia, V., Figueroa, J. M., Castanos, C. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Efficacy of oral corticosteroids in treating preschool wheeze: A systematic review and meta-analysis
Using oral corticosteroids (OCS) to treat acute wheeze in children aged 1-6 yrs has been contentious. Trial evidence is heterogeneous, as is clinical practice. We aimed to update the evidence on the efficacy of OCS as a treatment for acute preschool wheeze.We systematically searched studies published between 1994 and 2020 in eight databases. Eligible studies reported pooled estimates of the efficacy of OCS treatment for preschool wheeze. We performed a random-effects meta-analysis, employing the Hartung-Knapp-Sidik-Jonkman approach (1).Of 16,101 studies, 3 additional recent RCTs were included to those in previous systemati...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Lee, B., Twynam-Perkins, J., Turner, S., Lewis, S., Cunningham, S. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Serum Eosinophil-Derived Neurotoxin (EDN) is a Promising Biomarker for Recurrent Wheezing and Asthma in Preschool Children
Conclusions: Serum EDN is a promising eosinophil biomarker in preschool children with allergic symptoms and may help identify asthmatic children with recurrent wheezing.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Rydell, N., Kobori, T., Nagao, M., Moverare, R., Ekoff, H., Sjölander, A., Borres, M. P., Fujisawa, T. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Serum Eosinophil-Derived Neurotoxin is Associated with Symptom Severity During Acute Wheeze in Preschool Children
Conclusions: Serum EDN is a biomarker associated with IgE sensitization and severe symptoms in preschool children with acute wheeze.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Kobori, T., Rydell, N., Nagao, M., Moverare, R., Sjölander, A., Ekoff, H., Borres, M. P., Fujisawa, T. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Urinary eosinophil-derived neurotoxin in wheezing and asthmatic children
Conclusion: Children with atopic wheeze exhibit higher uEDN/uCr than non-atopic wheezers. Males showed higher uEDN/uCr than females for wheezers and asthmatics. Measurements of additional uEDN samples are on-going, intending to strengthen our inferences.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Omony, J., Thölken, C., Salimi, A., Laubhahn, K., Weckmann, M., Grychtol, R., Thiele, D., Kopp, M. V., Hansen, G., Renz, H., Von Mutius, E., Schaub, B., Skevaki, C. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Evaluation of nocturnal asthma control (NAC-study): Comparative multicenter analysis of subjective and objective methods
Conclusions: Objectively determined nocturnal symptoms are present in a considerable propotion of both fully and partially controlled asthmatic children. Night-time cough monitoring may be useful in evaluating asthma control.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Weisser, S., Lex, C., Roth, L., Kainz, K., Fajgelj, V., Schuetzenmeier, A., Fischer, P., Gross, V., Reinweber, M., Zacharasiewicz, A., Kerzel, S. Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Endotyping severe asthma with qPCR for five mast cell transcripts in induced sputum correlates with microscopy
Conclusion: This pilot study illustrates the potential of qPCR to endotype asthma at high resolution. It may improve the clinical impact of asthma endotyping.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Toennesen, B., Schmid, J. M., Fricker, M., Hoffmann, H. J. H. Tags: 05.03 - Allergy and immunology Source Type: research
The association between complement C3 and small airway impairment in asthma
In conclusion, we observed that both high and low levels of C3 in the lining fluid were associated with small airway impairment in asthma. Furthermore, high levels of C3 were associated with more systemic inflammation and less asthma control. These findings highlight the importance of the complement system in the pathogenesis of asthma.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Kokelj, S., Östling, J., Fromell, K., Nilsson Ekdahl, K., Nilsson, B., Olsson, H. K., Olin, A. Tags: 05.03 - Allergy and immunology Source Type: research
