Filtered By:
Source: European Respiratory Journal

This page shows you your search results in order of date. This is page number 6.

Order by Relevance | Date

Total 2423 results found since Jan 2013.

Onset, Maintenance, and Durability of Response with Dupilumab in Chronic Rhinosinusitis with Nasal Polyps
Conclusion: By W16, more dupilumab than pbo pts achieved clinically relevant response (onset), with the response maintained at W52 in >82% of dupilumab pts.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Bachert, C., Khan, A., Fokkens, W., Hopkins, C., Gevaert, P., Han, J., Hellings, P., Lee, S., Msihid, J., Nash, S., Siddiqui, S., Jacob-Nara, J., Deniz, Y., Rowe, P. Tags: 05.03 - Allergy and immunology Source Type: research

Salivary immunoglobulin E levels in patients treated with Omalizumab
Conclusion: In severe asthmatics, total IgE in saliva is associated with FEV1 and FVC. It has the potential to be a useful marker for monitoring the effects of IgE-targeting therapy. The small number of patients is the limitation of our ongoing study.Acknowledgments: The study is supported by the European Fund for regional development through Operational Program Science and Education for Smart Growth, Grant BG05M2OP001-1.002-0001-C04
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Hristova, D., Emilova, R., Todorova, Y., Aleksova, M., Nikolova, M. Tags: 05.03 - Allergy and immunology Source Type: research

Influence of polymorphisms in vitamin D receptor gene on severity and exacerbations of asthma
Conclusions: In this study, we found that the VDR rs2228570 AA genotype is associated with asthma severity and exacerbations. In addition, patients with the AA genotype have lower mRNA expression levels of VDR and molecules involved in steroid response. Our findings suggested the influence of polymorphisms VDR gene on the pathophysiology of asthma.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Uehara, S., Hirai, K., Shirai, T., Otaki, H., Akamatsu, T., Itoh, K. Tags: 05.03 - Allergy and immunology Source Type: research

Handgrip strength in adolescence - sex differences, determinants, and associations with Asthma-related Traits
Conclusion: We found sex-specific prenatal programming of HGS at age 18 years. HGS was associated with FEV1 and FVC, but not with airway resistance, reactivity, inflammation, or allergy measurements. HGS improved the accuracy of FEV1 estimation, but did not improve classification of asthma status, suggesting that the observed associations are not asthma-specific.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Hesselberg, L., Kyvsgaard, J. N., Stokholm, J., Bonnelykke, K., Bisgaard, H., Chawes, B. Tags: 07.02 - Paediatric asthma and allergy Source Type: research

The long-term effectiveness of allergy immunotherapy in subjects with asthma is associated with a lower prevalence of sleep disturbances. Results from the REACT-study
Respiratory allergy often affects the upper and lower airways as allergic rhinitis (AR) and asthma, with a negative impact on sleep. Allergy immunotherapy (AIT), particularly for house dust mite (HDM) allergy, has proven to be an effective treatment in asthma, but long-term data for AIT in asthma and sleep are sparse. The real-world effectiveness of AIT (REACT)-study was a large, retrospective German cohort study (2007-2017) with up to 9 years of follow-up. AIT was associated with long-term improved asthma control, reduced risk of asthma exacerbations and hospitalisations in patients with AR and pre-existing asthma (Fritzs...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Contoli, M., Fritzsching, B., Freemantle, N., Buchs, S., Larsen, J., Porsbjerg, C. Tags: 05.03 - Allergy and immunology Source Type: research

Mast cell gene expression in eosinophilic COPD patients
We examined associations between mast cell gene expression and T2 biomarkers. We measured mast cell numbers in bronchial biopsies by immunohistochemistry.Results: We observed increased expression of tryptase and carboxypeptidase mRNA, and a mast cell specific 11-gene signature in bronchial brushings and sputum cells of eosinophilhigh compared to eosinophillow COPD patients. The 11-gene signature was associated with airway eosinophil numbers, and IL-13 gene expression in bronchial brushings and sputum, and with IL-5 in sputum only (rho 0.4 – 0.8 p<0.05). There was no difference in the number of tissue mast cells be...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Higham, A., Dungwa, J., Pham, T., Mccrae, C., Singh, D. Tags: 05.03 - Allergy and immunology Source Type: research

Genome-wide exploration of inflammation-related proteins and Type 2 asthma
Conclusions: These results strongly suggest the existence of a genetic component influencing the levels of plasma proteins involved in inflammatory processes including MMP10, which could be a potential marker of high Type 2 inflammation patterns in asthma.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Hernandez-Pacheco, N., Björkander, S., Klevebro, S., Kebede Merid, S., Kumar, A., Mogensen, I., Janson, C., Palmberg, L., Van Hage, M., Georgellis, A., Bergström, A., Kull, I., Melen, E. Tags: 07.02 - Paediatric asthma and allergy Source Type: research

Allergy immunotherapy is associated with a reduced risk of asthma severity progression and lower airway infections. Results from the REACT-study
Respiratory allergy often affects upper and lower airways as allergic rhinitis (AR) and asthma as well as increases the risk of asthma exacerbations and pneumonia. Allergy immunotherapy (AIT) administered as the SQ house dust mite (HDM) sublingual immunotherapy (SLIT)-tablet has demonstrated efficacy for both AR and asthma in adults, but long-term data for AIT in asthma are sparse.The real-world effectiveness of AIT (REACT)-study was a retrospective cohort study (2007-2017). AIT was associated with a greater likelihood of step down in asthma controller treatment and reduced risk of asthma exacerbations and pneumonia in sub...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Porsbjerg, C., Fritzsching, B., Freemantle, N., Buchs, S., Larsen, J., Contoli, M. Tags: 05.03 - Allergy and immunology Source Type: research

Population PK/PD modelling of the anti-IL-33 antibody tozorakimab to predict pulmonary target engagement in patients with COPD
Conclusions: Our PK/PD model reliably predicts systemic target engagement by tozorakimab and can predict pulmonary target engagement. The model will help determine optimal tozorakimab dosing in future clinical trials.Reference1. Scott IC et al. Eur Respir J 2019 54:PA4072.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Sadiq, M. W., Yu, H., Astrand, M., Scott, I. C., Williams, A., Hewitt, L., White, N., Killick, H., Gavala, M., Reid, F., Kell, C., Pandya, H., Jimenez, E. Tags: 05.03 - Allergy and immunology Source Type: research

Airway inflammation before and after bronchial thermoplasty
Conclusion: Differences in gene sets pertaining to inflammatory status between treated and untreated airways after BT were identified, which was not reflected in cell counts and cytokines from BALF. Secondly, baseline epithelial glycolysis genes and eosinophils in BALF were different between responders and non-responders.Implication: This study shows the impact of BT on airway inflammation and can contribute to identify a BT responder profile.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Goorsenberg, A. W., Wijsman, P. C., Ravi, A., D'Hooghe, J. N., Dierdorp, B. S., Dekker, T., Van Schaik, C. C., Ten Hacken, N. H., Shah, P. L., Weersink, E. J., Bel, E. H., Annema, J. T., Lutter, R., Bonta, P. I. Tags: 05.03 - Allergy and immunology Source Type: research

Overall response to anti-IL5/anti-IL5R{alpha} treatment in severe asthma does not depend on initial bronchodilator responsiveness
Conclusions: Pulmonary function improved in both groups during anti-IL5/anti-IL5Rα treatment, but response patterns differed. However, both groups showed similar overall responses concerning reduction of OCS therapy, exacerbations and improvement of symptom control.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Mümmler, C., Suhling, H., Kneidinger, N., Buhl, R., Kayser, M., Drick, N., Behr, J., Welte, T., Korn, S., Milger, K. Tags: 05.03 - Allergy and immunology Source Type: research

Living with the risk of being infected: Asthma patients' experiences during the Covid-19 pandemic.
Conclusion: Patients with moderate to severe asthma feared death from COVID-19 and therefore felt compelled to self-insulate. Hence the need for more distance education and telemedicine.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: bounoua, F., Khannous, A., Moubachir, H., Serhane, H. Tags: 07.02 - Paediatric asthma and allergy Source Type: research

The prevalence, severity and risk factors of asthma in school-going adolescents in KwaZulu Natal, South Africa.
Conclusion: Asthma prevalence in this population is similar to the global average. Severe asthma symptoms are more common and are associated with atopy, environment, and lifestyle.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Mphahlele, R., Masekela, R. Tags: 07.02 - Paediatric asthma and allergy Source Type: research

Factors associated with middle-aged adult obstructive lung function deficits in the grass pollen season
Conclusion: Middle-aged adults with allergic disease or TRAP exposure may be more susceptible to obstructive lung function deficits during the grass pollen season. Genetics may also play a role, but further research on this is required.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Idrose, S., Vicendese, D., Abramson, M., Walters, E. H., Hamilton, G., Lowe, A., Douglass, J., Lodge, C., Dharmage, S. Tags: 05.03 - Allergy and immunology Source Type: research

Application of urinary proteomics for biomarker discovery in respiratory diseases
Conclusion: We have developed a protocol for the detection of proteomic biomarkers in urine. This proteome is enriched in proteins from the immune and respiratory systems, with a potential clinical and translational relevance.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Martelo-Vidal, L., Vazquez-Mera, S., Miguens-Suarez, P., Salgado-Castro, F. J., Blanco-Aparicio, M., Mosteiro-Anon, M., Martinez-Capoccioni, G., Mendez-Brea, P., Bravo, S. B., Gonzalez-Barcala, F., Nieto-Fontarigo, J. J. Tags: 05.03 - Allergy and immunology Source Type: research