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226 Characteristics of immune response profile in patients with immediate allergic and autoimmune urticarial reactions induced by COVID-19 vaccines
Allergic and hypersensitivity reactions induced by COVID-19 vaccines are increasingly reported and some patients may develop prolonged urticarial reactions following COVID-19 vaccination. Herein, we investigated the risk factors and immune mechanisms for patients with COVID-19 vaccines-induced immediate allergy and chronic urticaria (CU). We prospectively recruited and analyzed 129 patients with COVID-19 vaccine –induced immediate allergic and urticarial reactions as well as 115 COVID-19 vaccines–tolerant individuals from multiple medical centers during 2021–2022.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: C. Wang, C. Chen, W. Chung Source Type: research

Immediate Reaction to Propranolol: An Extremely Rare but Important Condition. A Case Report
CONCLUSION: We describe a new case of urticaria secondary to propranolol, presenting as an immediate hypersensitivity reaction. Bisoprolol has been succesfully proved to be a safe option. Bisoprolol is a second-generation beta-blocker, it is available and commercialized worldwide, which makes it a good alternative.PMID:37073669 | DOI:10.2174/1574886318666230417103423
Source: Current Drug Safety - April 17, 2023 Category: Drugs & Pharmacology Authors: Luc ía González-Bravo Mar ía-José Sánchez-González Jos é Barbarroja-Escudero Josefa Monjo-Paz Dorotea Matas-Dominguez Melchor Alvarez-Mon Source Type: research

Hymenoptera venom skin testing: Adopting an accelerated test protocol
CONCLUSION: The study underscores the overall safety of venom intradermal skin test. Majority of positive results occurred at 0.1 or 1 μg/ml. Adopting an accelerated approach would reduce time and cost associated with testing.PMID:37075978 | DOI:10.1016/j.anai.2023.04.004
Source: Annals of Allergy, Asthma and Immunology - April 17, 2023 Category: Allergy & Immunology Authors: Qing Wang Nora L Watson Douglas E Beakes David J Schwartz Source Type: research

Alpha-gal Syndrome Misdiagnosed As Chronic Spontaneous Urticaria Alpha-gal Syndrome Misdiagnosed As Chronic Spontaneous Urticaria
While alpha-gal syndrome usually is found in adults, this case illustrates that children can also present with this potentially life-threatening allergy to red meat.Journal of Medical Case Reports
Source: Medscape Allergy Headlines - April 14, 2023 Category: Allergy & Immunology Tags: Family Medicine/Primary Care Journal Article Source Type: news

Clavulanic Acid Is a Leading Culprit Beta-Lactam in Immediate Allergic Reactions to Penicillins
CONCLUSIONS: Selective immediate reactions to clavulanate accounted for over a third of cases with confirmed reactions after amoxicillin-clavulanate intake, with more than half experiencing anaphylaxis. Within this group, skin test sensitivity was below 50%. People taking amoxicillin-clavulanate may also be co-sensitized to both drugs.PMID:37021506 | DOI:10.4168/aair.2023.15.2.201
Source: Allergy, Asthma and Immunology Research - April 6, 2023 Category: Allergy & Immunology Authors: Isabel Torres-Rojas Diana P érez-Alzate Maria Luisa Somoza Ana Prieto-Moreno Pfeifer Elisa Haroun Diaz Teodorikez W Jimenez-Rodriguez Javier Fern ández Sánchez Francisco J Ruano Miguel Blanca Natalia Blanca-L ópez Source Type: research