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Efficacy of Second-Line Treatments in Chronic Urticaria Refractory to Standard Dose Antihistamines
CONCLUSIONS: In patients with CU refractory to standard doses of nsAHs, both updosing of nsAHs 4-fold and multiple combination treatment with 4 nsAHs increased the rate of well-controlled cases without causing significant adverse effects. Updosing of nsAHs is more effective for complete CU control than combination treatment.PMID:37153977
Source: Allergy, Asthma and Immunology Research - May 8, 2023 Category: Allergy & Immunology Authors: Mi-Ae Kim Jeong-Hee Choi Yoo-Seob Shin Hae-Sim Park Young-Min Ye KAAACI Work Group on Urticaria/Angioedema/Anaphylaxis Source Type: research

A Case Series of Chronic Spontaneous Urticaria After COVID-19 Vaccination
Allergy Asthma Immunol Res. 2023 Jan 26. Online ahead of print.NO ABSTRACTPMID:37153976
Source: Allergy, Asthma and Immunology Research - May 8, 2023 Category: Allergy & Immunology Authors: Jeong-Hee Choi Soo Jie Chung Source Type: research

Alpha-gal syndrome: a review for the dermatologist.
Alpha-gal syndrome (AGS) is an allergy to “red” meat and other mammalian products due to immunoglobulin E (IgE) antibodies against the sugar moiety galactose-alpha-1,3-galactose (alpha-gal), which is acquired following tick bites. Clinically, AGS presents with urticaria, abdominal pain, nausea, and occasionally anaphylaxis, and has wide inter- and intra-personal variability. Because symptom onset is generally delayed by two to six hours after meat consumption, AGS can be easily confused with other causes of urticaria and anaphylaxis, such as chronic spontaneous urticaria (CSU) and mast cell activation syndrome (MCAS).
Source: Journal of the American Academy of Dermatology - May 5, 2023 Category: Dermatology Authors: Soumya Reddy, Lauren Yi, Bridget Shields, Thomas Platts-Mills, Jeffrey Wilson, R. Hal Flowers Source Type: research

Alpha-gal syndrome: A review for the dermatologist
Alpha-gal syndrome (AGS) is an allergy to “red meat” and other mammalian products due to immunoglobulin E (IgE) antibodies against the sugar moiety galactose-alpha-1,3-galactose (alpha-gal), which is acquired following tick bites. Clinically, AGS presents with urticaria, abdominal pain, nausea, and occasionally anaphylaxis, and has wide inter- and intra-personal variability. Because symptom onset is generally delayed by 2 to 6 hours after meat consumption, AGS can be easily confused with other causes of urticaria and anaphylaxis, such as chronic spontaneous urticaria (CSU) and mast cell activation syndrome (MCAS).
Source: Journal of the American Academy of Dermatology - May 5, 2023 Category: Dermatology Authors: Soumya Reddy, Lauren Yi, Bridget Shields, Thomas Platts-Mills, Jeffrey Wilson, R. Hal Flowers Tags: Clinical review Source Type: research

Dermatological conditions associated with dental professionals in Saudi Arabia
CONCLUSION: There was a lack of awareness among both the dentists and students regarding work-related skin lesions and getting them treated by dermatologists at the earliest, though the dentists' level of knowledge was better than that of the students. Thus, various educational programs on dermatological lesions should be implemented so that dental professionals and students take necessary precautions and seek treatment for skin disorders.PMID:37122669 | PMC:PMC10131953 | DOI:10.4103/jfmpc.jfmpc_1051_22
Source: Primary Care - May 1, 2023 Category: Primary Care Authors: Raghad Mohammed Alzaid Rafi Ahmad Togoo Amjad Saad Alshehri Raneem Mohammed Alribah Rawan Zaid Asiri Raneem Mohammed Alhefze Source Type: research

Safety and outcomes of "at-home self-provocation tests" in patients with mild NSAID-induced urticaria/angioedema (NIUA)
Ann Allergy Asthma Immunol. 2023 Apr 23:S1081-1206(23)00284-3. doi: 10.1016/j.anai.2023.04.017. Online ahead of print.NO ABSTRACTPMID:37098402 | DOI:10.1016/j.anai.2023.04.017
Source: Annals of Allergy, Asthma and Immunology - April 25, 2023 Category: Allergy & Immunology Authors: So-Young Park Young-Sang Yoo Jin-Young Huh Daegeun Lee Jae-Woo Jung Ji-Hyang Lee Woo-Jung Song Tae-Bum Kim You-Sook Cho Hyouk-Soo Kwon Source Type: research

Safety and outcomes of “at-home self-provocation tests” in patients with mild NSAID-induced urticaria/angioedema (NIUA)
Drug hypersensitivity reactions (DHRs) are unpredictable and heterogeneous type B adverse drug reactions (ADRs).1,2 Various drugs can lead to hypersensitivity; however, nonsteroidal anti-inflammatory drugs (NSAIDs) are recognized as one of the most common causes.3,4 Although NSAID hypersensitivity varies in symptoms, time of onset, and involved mechanisms, it can be categorized according to two major mechanisms: (1) non-immunological mechanisms, such as pharmacologic (secondary to cyclooxygenase-1 (COX-1) inhibition); or (2) immune-mediated reactions (specific IgE or T cells).
Source: Annals of Allergy, Asthma and Immunology - April 23, 2023 Category: Allergy & Immunology Authors: So-Young Park, Young-Sang Yoo, Jin-Young Huh, Daegeun Lee, Jae-Woo Jung, Ji-Hyang Lee, Woo-Jung Song, Tae-Bum Kim, You-Sook Cho, Hyouk-Soo Kwon Tags: Original Article Source Type: research

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