Subject: Letter to the editor regarding the article “A systematic review on the effects of direct oral anticoagulants on cancer growth and metastasis in animal models”
We are writing to address a concern regarding the recent article by Najidh et al. in Thrombosis Research, which examines the effects of direct oral anticoagulants on cancer growth and metastasis in animal models. (Source: Thrombosis Research)
Source: Thrombosis Research - May 8, 2024 Category: Hematology Authors: Huda Moutaz Asmael Al-Azzawi, Antonio Celentano Tags: Letter to the Editors-in-Chief Source Type: research
Reply to ‘letter-to-the-editor’
We thank ≪authors≫ for their comments and the opportunity to discuss the inclusion of a carcinogenicity animal study [1] in our systematic review, in which we described the effects of direct oral anticoagulants on cancer growth and metastasis in animal models [2]. (Source: Thrombosis Research)
Source: Thrombosis Research - May 7, 2024 Category: Hematology Authors: J.T. Buijs, S. Najidh, H.H. Versteeg Tags: Letter to the Editors-in-Chief Source Type: research
Venous thromboembolism in Black COVID-19 patients in a minority context compared to White, Asian and other racialized patients: A systematic review and meta-analysis
COVID-19 has disproportionately affected racialized populations, with particular impact among individuals of Black individuals. However, it is unclear whether disparities in venous thromboembolic (VTE) complications exist between Black individuals and those belonging to other racial groups with confirmed SARS-CoV2 infections. (Source: Thrombosis Research)
Source: Thrombosis Research - May 7, 2024 Category: Hematology Authors: Jude Mary C énat, Elisabeth Dromer, Seyed Mohammad Mahdi Moshirian Farahi, Christa Masengesho Ndamage, Aiden Yun, Hannah Zuta, Jihane Mkhatri, Eden Samson, Raina Barara, Patrick R. Labelle, Yan Xu Tags: Review Article Source Type: research
Detection and management of clinically relevant drug-drusg interactions with direct oral anticoagulants: An intervention study in community pharmacies
In this study, we aimed to investigate the impact of the detection and management of DDIs with DOACs in a real-life community pharmacy setting on the pharmacotherapy of DOAC users. (Source: Thrombosis Research)
Source: Thrombosis Research - May 6, 2024 Category: Hematology Authors: Andreas Capiau, Els Mehuys, Maxim Grymonprez, Inge Van Tongelen, Thierry Christiaens, Eline Tommelein, Genevi ève Philippe, Lies Lahousse, Tine De Backer, Koen Boussery Source Type: research
The DOAC (direct oral anticoagulant) dipstick reliably excludes residual FXa inhibitors levels in the perioperative setting
Before performing certain interventional procedures, it is essential for patient safety to confirm the absence of residual therapeutic DOAC plasma levels. In addition, in emergencies such as major hemorrhage, crush trauma, or in patients actively anticoagulated with a DOAC who present with a hip fracture, it is important to promptly determine DOAC exposure and administer a reversal agent if necessary. While the gold standard for quantifying DOACs is ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS), this expensive, time-consuming, and expertise-requiring method is incompatible...
Source: Thrombosis Research - May 6, 2024 Category: Hematology Authors: Julie Vassart, Alfonso Tafur, Marisa Durante, Anne-Yseult Boucher, Laure Morimont, Jeanine M. Walenga, Job Harenberg, Jonathan Douxfils Tags: Letter to the Editors-in-Chief Source Type: research
Elevated plasma levels of factor VIII enhance arterial thrombus formation on erosive smooth muscle cell-rich neointima but not normal intima in rabbits
Plaque erosion, a type of coronary atherothrombosis, involves superficial injury to smooth muscle cell (SMC)-rich plaques. Elevated levels of coagulation factor VIII (FVIII) correlate with an increased ischemic heart disease risk. FVIII may contribute to thrombus formation on eroded plaques. (Source: Thrombosis Research)
Source: Thrombosis Research - May 5, 2024 Category: Hematology Authors: Chihiro Sugita, Kazunari Maekawa, Toshihiro Gi, Nobuyuki Oguri, Eriko Nakamura, Eiji Furukoji, Minako Azuma, Yujiro Asada, Atsushi Yamashita Tags: Full Length Article Source Type: research
Immunological role of Gas6/TAM signaling in hemostasis and thrombosis
The immune system is an emerging regulator of hemostasis and thrombosis. The concept of immunothrombosis redefines the relationship between coagulation and immunomodulation, and the Gas6/Tyro3-Axl-MerTK (TAM) signaling pathway builds the bridge across them. During coagulation, Gas6/TAM signaling pathway not only activates platelets, but also promotes thrombosis through endothelial cells and vascular smooth muscle cells involved in inflammatory responses. Thrombosis appears to be a common result of a Gas6/TAM signaling pathway-mediated immune dysregulation. (Source: Thrombosis Research)
Source: Thrombosis Research - May 2, 2024 Category: Hematology Authors: Fanshu Li, Liling Xu, Chun Li, Fanlei Hu, Yin Su Tags: Review Article Source Type: research
AAV mediated genome engineering with a bypass coagulation factor alleviates the bleeding phenotype in a murine model of hemophilia B
It is crucial to develop a long-term therapy that targets hemophilia A and B, including inhibitor-positive patients. We have developed an Adeno-associated virus (AAV) based strategy to integrate the bypass coagulation factor FVIIa (murine, mFVIIa) gene into the Rosa26 locus using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 mediated gene editing. AAV vectors designed for expression of guide RNA (AAV8-gRNA), Cas9 (AAV2 neddylation mutant-Cas9), and mFVIIa (AAV8-mFVIIa) flanked by homology arms of the target locus were validated in vitro. (Source: Thrombosis Research)
Source: Thrombosis Research - May 2, 2024 Category: Hematology Authors: Pratiksha Sarangi, Narendra Kumar, Ramkumar Sambasivan, Sivaprakash Ramalingam, Sonal Amit, Dinesh Chandra, Giridhara R. Jayandharan Tags: Full Length Article Source Type: research
Management options for pediatric venous thromboembolic disease: Beyond anticoagulation with endovascular therapies
Venous thromboembolism (VTE) in pediatric patients is an uncommon but serious diagnosis that has an array of therapeutic options and challenges. An assessment of the existing literature on management of pediatric patients with VTE was conducted. The interventions reviewed include anticoagulation, thrombolysis, thrombectomy, inferior vena cava (IVC) filters, and venous stenting. For each intervention, a discussion of mechanism of action, indications, contraindications, and potential complications was performed. (Source: Thrombosis Research)
Source: Thrombosis Research - May 2, 2024 Category: Hematology Authors: Priyanka Mitta, Jake DiFatta, Chase Mahler, Junjian Huang, Rachel Oser, Andrew John Gunn, Hope Wilson, Junaid Raja Tags: Review Article Source Type: research
Neutrophil extracellular traps formation may be involved in the association of propranolol with the development of portal vein thrombosis
Nonselective β blockers (NSBBs) facilitate the development of portal vein thrombosis (PVT) in liver cirrhosis. Considering the potential effect of NSBBs on neutrophils and neutrophil extracellular traps (NETs), we speculated that NSBBs might promote the development of PVT by stimulating neutrophils to release N ETs. (Source: Thrombosis Research)
Source: Thrombosis Research - May 1, 2024 Category: Hematology Authors: Xiangbo Xu, Shixue Xu, Yiyan Zhang, Le Wang, Chenghui Yan, Zihua Xu, Qingchun Zhao, Xingshun Qi Tags: Full Length Article Source Type: research
Anticoagulation in COVID-19 patients – An updated systematic review and meta-analysis
Thromboembolic events are common complications of COVID-19. Clinical study results on safety and efficacy of anticoagulation in COVID-19 are controversial. (Source: Thrombosis Research)
Source: Thrombosis Research - May 1, 2024 Category: Hematology Authors: Stefanie Reis, Amon Faske, Ina Monsef, Florian Langer, Oliver J. M üller, Peter Kranke, Patrick Meybohm, Stephanie Weibel Tags: Full Length Article Source Type: research
Downregulation of protein S in patients with severe COVID-19 augments the prothrombotic state
We hereby report the significance of Protein S (PS) in the thromboembolic pathway in relation to COVID-19, the SARS-CoV-2 virus disease. COVID-19 is a multi-system inflammatory disease that has wreaked international havoc since December 2019 [1]. A characteristic of COVID-19 is aberrations in the coagulation cascade that result in elevated D-dimer level, which indicates a procoagulant state. This disease process leads to serious illnesses such as stroke, pulmonary embolism, myocardial infarction, and acute kidney injury [2 –4]. (Source: Thrombosis Research)
Source: Thrombosis Research - May 1, 2024 Category: Hematology Authors: Devin Melancon, Tina Nguyen, Verima Pereira, Jarrod Harman, Sabyasachi Chatterjee, Arnold H. Zea, Samarpan Majumder, Rinku Majumder Tags: Letter to the Editors-in-Chief Source Type: research
Oral anticoagulants and cognitive impairment in patients with atrial fibrillation: A systematic review with meta-analysis and trial sequential analysis
This systematic review assesses the likelihood of developing dementia and cognitive impairment in patients with atrial fibrillation (AF) receiving non-vitamin K antagonist oral anticoagulants (NOACs) as opposed to vitamin K antagonists (VKAs). (Source: Thrombosis Research)
Source: Thrombosis Research - April 30, 2024 Category: Hematology Authors: Kun-Han Lee, Jiunn-Tyng Yeh, Meng-Lun Wu, Wan-Yu Yeh, Gregory Y.H. Lip, Chern-En Chiang, Chen-Huan Chen, Hao-Min Cheng Source Type: research
Myocardial ischemia-reperfusion injury released cellular fibronectin containing domain A (CFN-EDA): A destructive positive loop amplifying arterial thrombosis formation and exacerbating myocardial reperfusion injury
This study utilizes intravital microscopy to investigate carotid artery thrombosis during MI/R injury in rats, establishing a connection with the presence of prothrombotic cellular fibronectin containing extra domain A (CFN-EDA) protein. Additionally, the study examines samples from patients with coronary artery disease (CAD) both before and after coronary artery bypass grafting (CABG). (Source: Thrombosis Research)
Source: Thrombosis Research - April 29, 2024 Category: Hematology Authors: Moh Uzair, Chahak Singhal, Azeem Ali, Sangam Rajak, Aditya Kapoor, Surendra Kumar Agarwal, Swasti Tiwari, Shantanu Pande, Prem Prakash Tags: Full Length Article Source Type: research
The course of pulmonary embolism in individuals recovered from COVID-19
Coronavirus disease 2019 (COVID-19) has been associated with various late complications, particularly affecting the lungs, heart, and brain [1]. Previous studies reported statistically significant increased rates of cardiopulmonary complications during long-term term follow-up (>1 year) in patients who had recovered from COVID-19 [2]. (Source: Thrombosis Research)
Source: Thrombosis Research - April 29, 2024 Category: Hematology Authors: Co şkun Doğan, Samet Samanci Tags: Letter to the Editors-in-Chief Source Type: research
