Elevated plasma levels of factor VIII enhance arterial thrombus formation on erosive smooth muscle cell-rich neointima but not normal intima in rabbits

Plaque erosion, a type of coronary atherothrombosis, involves superficial injury to smooth muscle cell (SMC)-rich plaques. Elevated levels of coagulation factor VIII (FVIII) correlate with an increased ischemic heart disease risk. FVIII may contribute to thrombus formation on eroded plaques.

Source: Thrombosis Research - May 5, 2024 Category: Hematology Authors: Chihiro Sugita, Kazunari Maekawa, Toshihiro Gi, Nobuyuki Oguri, Eriko Nakamura, Eiji Furukoji, Minako Azuma, Yujiro Asada, Atsushi Yamashita Tags: Full Length Article Source Type: research