Downregulation of protein S in patients with severe COVID-19 augments the prothrombotic state

We hereby report the significance of Protein S (PS) in the thromboembolic pathway in relation to COVID-19, the SARS-CoV-2 virus disease. COVID-19 is a multi-system inflammatory disease that has wreaked international havoc since December 2019 [1]. A characteristic of COVID-19 is aberrations in the coagulation cascade that result in elevated D-dimer level, which indicates a procoagulant state. This disease process leads to serious illnesses such as stroke, pulmonary embolism, myocardial infarction, and acute kidney injury [2 –4].
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research