Lung adenocarcinoma with EGFR L858R-K860I and L858R-L861F doublet mutations from which the L858R mutation is undetectable through the cobas EGFR mutation test v2
Pathol Res Pract. 2024 Apr 15;257:155304. doi: 10.1016/j.prp.2024.155304. Online ahead of print.ABSTRACTIn East Asia, epidermal growth receptor factor (EGFR) mutations are the most prevalent and important biomarkers for treating patients with advanced lung cancer. However, as L858R doublet mutations are rare, commercially available EGFR tests may yield false-negative results. To determine whether the L858R mutation of the L858R-K860I and L858R-L861F doublet mutations could be identified using different types of EGFR detection tests and to describe the clinical response of patients with lung cancer with L858R doublet mutati...
Source: Pathology, Research and Practice - April 24, 2024 Category: Pathology Authors: Chi-Hsuan Wu Man-San Zhang Yen-Lin Huang Wei-Hsiang Cheng Jin-Yao Lai Min-Shu Hsieh Wei-Yu Liao Source Type: research
Curcumin-loaded liposomes modulating the synergistic role of EpCAM and estrogen receptor alpha in lung cancer management
This study delves into the in vitro potential of liposomal therapeutics utilizing Curcumin-loaded PlexoZome® (CUR-PLXZ) in targeting EpCAM/TROP1 and Estrogen Receptor Alpha (ERα) signalling pathways for LC management. The prevalence of LC, particularly non-small cell lung cancer (NSCLC), underscores the urgent need for effective treatments. Biomarkers like EpCAM/TROP1 and ERα/NR3A1 play crucial roles in guiding targeted therapies and influencing prognosis. EpCAM plays a key role in cell-cell adhesion and signalling along with ERα which is a nuclear receptor that binds estrogen and regulates gene expression in response ...
Source: Pathology, Research and Practice - April 24, 2024 Category: Pathology Authors: Manisha Singh Gabriele De Rubis Sofia Kokkinis Keshav Raj Paudel Stewart Yeung Philip Michael Hansbro Brian Gregory George Oliver Kamal Dua Source Type: research
Clinical characteristics, proteins, and genes related to interstitial pneumonia-associated squamous cell carcinoma of the lungs
Pathol Res Pract. 2024 Apr 7;257:155292. doi: 10.1016/j.prp.2024.155292. Online ahead of print.ABSTRACTSquamous cell carcinoma (SCC) is a common histological type of lung carcinoma that is associated with interstitial pneumonia (IP). We hypothesized that identifying specific genetic alterations or molecular markers of SCC with IP may aid the development of novel therapeutic strategies for the same. Therefore, in the present study, we aimed to identify tumorigenic genetic alterations and molecular markers in cases of SCC with IP. We included 28 lung SCC cases (14 cases with IP and 14 cases without IP). We performed immunohi...
Source: Pathology, Research and Practice - April 24, 2024 Category: Pathology Authors: Akiko Mochizuki Haruto Nishida Ryo Kaimori Yoshihiko Kondo Hiroko Kadowaki Takahiro Kusaba Kazuhiro Kawamura Atsushi Osoegawa Kenji Sugio Tsutomu Daa Source Type: research
Dendritic cell-derived exosome (DEX) therapy for digestive system cancers: Recent advances and future prospect
Pathol Res Pract. 2024 Apr 6;257:155288. doi: 10.1016/j.prp.2024.155288. Online ahead of print.ABSTRACTTumor-mediated immunosuppression is a fundamental obstacle to the development of dendritic cell (DC)-based cancer vaccines, which despite their ability to stimulate host anti-tumor CD8 T cell immunity, have not been able to generate meaningful therapeutic responses. Exosomes are inactive membrane vesicles that are nanoscale in size and are produced by the endocytic pathway. They are essential for intercellular communication. Additionally, DC-derived exosomes (DEXs) contained MHC class I/II (MHCI/II), which is frequently c...
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Sulieman Ibraheem Shelash Al-Hawary Yasir Qasim Almajidi Pooja Bansal Irfan Ahmad Harpreet Kaur Ahmed Hjazi Mahamedha Deorari Ahmed Hussein Zwamel Hamza Fadhel Hamzah Bahira Abdulrazzaq Mohammed Source Type: research
Advances in glioblastoma multiforme: Integrating therapy and pathology perspectives
In conclusion, our efforts offer hope for enhanced outcomes and improved quality of life for GBM patients through alkaloid-based therapies. By integrating insights from pathology and therapeutic perspectives, we underscore the significance of a comprehensive approach in addressing this devastating disease.PMID:38653089 | DOI:10.1016/j.prp.2024.155285 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Seyed Hossein Shahcheraghi Maliheh Alimardani Malihe Lotfi Marzieh Lotfi Vladimir N Uversky Stephanie Tamdem Guetchueng Sushesh Shrivastsa Palakurthi Nitin B Charbe Altijana Hromi ć-Jahjefendić Alaa A A Aljabali Manoj M Gadewar Sumira Malik Rohit Goyal Source Type: research
Riddle of the Sphinx: Emerging role of circular RNAs in cervical cancer
Pathol Res Pract. 2024 Apr 17;257:155315. doi: 10.1016/j.prp.2024.155315. Online ahead of print.ABSTRACTCervical cancer is a prominent cause of cancer-related mortality among women, with recent attention directed toward exploring the involvement of circular RNAs (circRNAs) in this particular cancer. CircRNAs, characterized by a covalently closed loop structure, belong to a class of single-stranded non-coding RNA (ncRNA) molecules that play crucial roles in cancer development and progression through diverse mechanisms. The abnormal expression of circRNAs in vivo is significantly associated with the development of cervical c...
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Caiyan Yin Jianwei Yu Gaohua Liu Jun He Peng Wu Source Type: research
NUPR1 induces autophagy and promotes the progression of Esophageal squamous cell carcinoma via the MAPK-mTOR pathway
CONCLUSION: Collectively, our findings show that NUPR1 enhances the progression of ESCC by triggering autophagy and is associated with the MAPK-mTOR signaling pathway.PMID:38653091 | DOI:10.1016/j.prp.2024.155323 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Shiheng Ren Yuxin Chen Qiang Wang Liang Song Zhongwei Xin Mo Shi Xiangyan Liu Source Type: research
NUPR1 induces autophagy and promotes the progression of Esophageal squamous cell carcinoma via the MAPK-mTOR pathway
CONCLUSION: Collectively, our findings show that NUPR1 enhances the progression of ESCC by triggering autophagy and is associated with the MAPK-mTOR signaling pathway.PMID:38653091 | DOI:10.1016/j.prp.2024.155323 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Shiheng Ren Yuxin Chen Qiang Wang Liang Song Zhongwei Xin Mo Shi Xiangyan Liu Source Type: research
Dendritic cell-derived exosome (DEX) therapy for digestive system cancers: Recent advances and future prospect
Pathol Res Pract. 2024 Apr 6;257:155288. doi: 10.1016/j.prp.2024.155288. Online ahead of print.ABSTRACTTumor-mediated immunosuppression is a fundamental obstacle to the development of dendritic cell (DC)-based cancer vaccines, which despite their ability to stimulate host anti-tumor CD8 T cell immunity, have not been able to generate meaningful therapeutic responses. Exosomes are inactive membrane vesicles that are nanoscale in size and are produced by the endocytic pathway. They are essential for intercellular communication. Additionally, DC-derived exosomes (DEXs) contained MHC class I/II (MHCI/II), which is frequently c...
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Sulieman Ibraheem Shelash Al-Hawary Yasir Qasim Almajidi Pooja Bansal Irfan Ahmad Harpreet Kaur Ahmed Hjazi Mahamedha Deorari Ahmed Hussein Zwamel Hamza Fadhel Hamzah Bahira Abdulrazzaq Mohammed Source Type: research
Advances in glioblastoma multiforme: Integrating therapy and pathology perspectives
In conclusion, our efforts offer hope for enhanced outcomes and improved quality of life for GBM patients through alkaloid-based therapies. By integrating insights from pathology and therapeutic perspectives, we underscore the significance of a comprehensive approach in addressing this devastating disease.PMID:38653089 | DOI:10.1016/j.prp.2024.155285 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Seyed Hossein Shahcheraghi Maliheh Alimardani Malihe Lotfi Marzieh Lotfi Vladimir N Uversky Stephanie Tamdem Guetchueng Sushesh Shrivastsa Palakurthi Nitin B Charbe Altijana Hromi ć-Jahjefendić Alaa A A Aljabali Manoj M Gadewar Sumira Malik Rohit Goyal Source Type: research
Riddle of the Sphinx: Emerging role of circular RNAs in cervical cancer
Pathol Res Pract. 2024 Apr 17;257:155315. doi: 10.1016/j.prp.2024.155315. Online ahead of print.ABSTRACTCervical cancer is a prominent cause of cancer-related mortality among women, with recent attention directed toward exploring the involvement of circular RNAs (circRNAs) in this particular cancer. CircRNAs, characterized by a covalently closed loop structure, belong to a class of single-stranded non-coding RNA (ncRNA) molecules that play crucial roles in cancer development and progression through diverse mechanisms. The abnormal expression of circRNAs in vivo is significantly associated with the development of cervical c...
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Caiyan Yin Jianwei Yu Gaohua Liu Jun He Peng Wu Source Type: research
Critical role of miR-21/exosomal miR-21 in autophagy pathway
Pathol Res Pract. 2024 Mar 30;257:155275. doi: 10.1016/j.prp.2024.155275. Online ahead of print.ABSTRACTActivation of autophagy, a process of cellular stress response, leads to the breakdown of proteins, organelles, and other parts of the cell in lysosomes, and can be linked to several ailments, such as cancer, neurological diseases, and rare hereditary syndromes. Thus, its regulation is very carefully monitored. Transcriptional and post-translational mechanisms domestically or in whole organisms utilized to control the autophagic activity, have been heavily researched. In modern times, microRNAs (miRNAs) are being conside...
Source: Pathology, Research and Practice - April 21, 2024 Category: Pathology Authors: Mohamed J Saadh Morug Salih Mahdi Omer Qutaiba B Allela Tuqa S Alazzawi Mohammed Ubaid Nodir M Rakhimov Zainab H Athab Pushpamala Ramaiah Lathamangeswari Chinnasamy Fahad Alsaikhan Bagher Farhood Source Type: research
Evaluation of expression level of BANCR, MALAT1 and FER1L4 and their target genes in coumarin-treated AGS cell line
In this study, we investigated the expression level of selected cellular lncRNAs (BANCR, MALAT1 and FER1L4) and their target genes (PTEN, p-PI3K and p-AKT) in coumarin-treated AGS cell line. The expressions of the three lncRNAs: BANCR, MALAT1 and FER1L4, as well as their specified targets, PTEN, PI3K and AKT, were measured by qRT-PCR. To gauge the impact of coumarin on the AGS cells, a MTT assay was utilized. A Western blot has been employed to assess variations in PTEN, p-PI3K, and p-AKT expression. The experiment's results showed that AGS viability diminished with increasing doses of coumarin. Compared to the control cel...
Source: Pathology, Research and Practice - April 21, 2024 Category: Pathology Authors: Shirin Shafaee Arani Majid Nejati Sepide Rastgoufar Arash Raisi Reza Eshraghi Amirreza Ostadian Amir Hassan Matini Neda Rahimain Hamed Mirzaei Source Type: research
Exosome secretion related gene signature predicts chemoresistance in patients with colorectal cancer
CONCLUSIONS: In summary, the gene signature related to exosome formation and secretion could reliably predict patients' chemosensitivity and ICB treatment response, which providing new independent biomarkers for the treatment of CRC.PMID:38642509 | DOI:10.1016/j.prp.2024.155313 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 20, 2024 Category: Pathology Authors: Liang Ming Junhui Tang Feiyu Qin Yan Qin Duo Wang Liuying Huang Yulin Cao Zhaohui Huang Yuan Yin Source Type: research
Investigation of smoking on the antiplatelet response to clopidogrel: Unravelling the smoker's paradox
Pathol Res Pract. 2024 Apr 10;257:155290. doi: 10.1016/j.prp.2024.155290. Online ahead of print.ABSTRACTThe intricate relationship between smoking and the effects of the antiplatelet drug clopidogrel has been termed the "smoker's paradox". This paradox details the enhanced efficacy of clopidogrel in smokers compared to non-smokers. This review begins with an exploration of the proposed mechanisms of the smoker's paradox, particularly drawing attention to the induction of cytochrome P450 (CYP) isoenzymes via tobacco smoke, specifically the enzymes CYP1A2 and CYP2C19. Moreover, an investigation of the effects of genetic vari...
Source: Pathology, Research and Practice - April 19, 2024 Category: Pathology Authors: Frank A Plakogiannis Jakob Weidmann Blake Fraser Justin Kwong Diana Asi Pratham Kumar Madeleine Baldock Jasmine Naamo Ruhani Baluja Rachelle Catanzariti Stewart Yeung Lisa Pont Kylie Williams Gabriele De Rubis Kamal Dua Nadeem Irfan Bukhari Source Type: research
