Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates
Neuropharmacology. 2024 Apr 22:109963. doi: 10.1016/j.neuropharm.2024.109963. Online ahead of print.ABSTRACTValproic acid (VPA) is an effective and commonly prescribed drug for epilepsy and bipolar disorder. However, children born from mothers treated with VPA during pregnancy exhibit an increased incidence of autism spectrum disorder (ASD). Although VPA may impair brain development at the cellular level, the mechanism of VPA-induced ASD has not been completely addressed. A previous study has found that VPA treatment strongly reduces δ-catenin mRNA levels in cultured human neurons. δ-catenin is important for the control ...
Source: Neuropharmacology - April 24, 2024 Category: Drugs & Pharmacology Authors: Seung Hyun Roh Hadassah Mendez-Vazquez Matheus F Sathler Michael J Doolittle Anastasiya Zaytseva Hannah Brown Morgan Sainsbury Seonil Kim Source Type: research
Analgesic effect of Botulinum toxin in neuropathic pain is sodium channel independent
Neuropharmacology. 2024 Apr 22:109967. doi: 10.1016/j.neuropharm.2024.109967. Online ahead of print.ABSTRACTBotulinum neurotoxin type A BoNT/A is used off-label as a third line therapy for neuropathic pain. However, the mechanism of action remains unclear. In recent years, the role of voltage-gated sodium channels (Nav) in neuropathic pain became evident and it was suggested that block of sodium channels by BoNT/A would contribute to its analgesic effect. We assessed sodium channel function in the presence of BoNT/A in heterologously expressed Nav1.7, Nav1.3, and the neuronal cell line ND7/23 by high throughput automated a...
Source: Neuropharmacology - April 24, 2024 Category: Drugs & Pharmacology Authors: Aylin B Kesdo ğan Anika Neureiter Arnim J Gaebler Anil K Kalia Jannis K örner Angelika Lampert Source Type: research
Examination Of The Effects Of Vitexin And Vitexin-Loaded Solid Lipid Nanoparticles On Neuropathic Pain And Possible Mechanisms Of Action
In conclusion, vitexin and vitexin-loaded formulation have the potential for clinical use in neuropathic pain management, and different pain pathways contributed to this effect. And also, it is thought that vitexin-loaded SLN formulation is more effective than pure vitexin, which will provide an advantage in treatment.PMID:38657947 | DOI:10.1016/j.neuropharm.2024.109961 (Source: Neuropharmacology)
Source: Neuropharmacology - April 24, 2024 Category: Drugs & Pharmacology Authors: Hazal Eken Nurcan Bektas Turkmen Behiye Senel Rana Arslan Source Type: research
Acute nicotine activates orectic and inhibits anorectic brain regions in rats exposed to chronic nicotine
Neuropharmacology. 2024 Apr 20:109959. doi: 10.1016/j.neuropharm.2024.109959. Online ahead of print.ABSTRACTNicotine use produces psychoactive effects, and chronic use is associated with physiological and psychological symptoms of addiction. However, chronic nicotine use is known to decrease food intake and body weight gain, suggesting that nicotine also affects central metabolic and appetite regulation. We recently showed that acute nicotine self-administration in nicotine-dependent animals produces a short-term increase in food intake, contrary to its long-term decrease of feeding behavior. As feeding behavior is regulat...
Source: Neuropharmacology - April 22, 2024 Category: Drugs & Pharmacology Authors: Kokila Shankar S élène Bonnet-Zahedi Kristel Milan Andrea Ruiz D'argence Elizabeth Sneddon Ran Qiao Supakorn Chonwattangul Lieselot Lg Carrette Marsida Kallupi Olivier George Source Type: research
Acute nicotine activates orectic and inhibits anorectic brain regions in rats exposed to chronic nicotine
Neuropharmacology. 2024 Apr 20:109959. doi: 10.1016/j.neuropharm.2024.109959. Online ahead of print.ABSTRACTNicotine use produces psychoactive effects, and chronic use is associated with physiological and psychological symptoms of addiction. However, chronic nicotine use is known to decrease food intake and body weight gain, suggesting that nicotine also affects central metabolic and appetite regulation. We recently showed that acute nicotine self-administration in nicotine-dependent animals produces a short-term increase in food intake, contrary to its long-term decrease of feeding behavior. As feeding behavior is regulat...
Source: Neuropharmacology - April 22, 2024 Category: Drugs & Pharmacology Authors: Kokila Shankar S élène Bonnet-Zahedi Kristel Milan Andrea Ruiz D'argence Elizabeth Sneddon Ran Qiao Supakorn Chonwattangul Lieselot Lg Carrette Marsida Kallupi Olivier George Source Type: research
Retraction Notice to "Genistein improves sensorimotor gating: Mechanisms related to its neuroprotective effects on the striatum" [Neuropharm. 105 (2016) 35-46]
Neuropharmacology. 2024 Apr 20:109964. doi: 10.1016/j.neuropharm.2024.109964. Online ahead of print.NO ABSTRACTPMID:38644148 | DOI:10.1016/j.neuropharm.2024.109964 (Source: Neuropharmacology)
Source: Neuropharmacology - April 21, 2024 Category: Drugs & Pharmacology Authors: Esther T Menze Ahmed Esmat Mariane G Tadros Amani E Khalifa Ashraf B Abdel-Naim Source Type: research
Single administration of a psychedelic [(R)-DOI] influences coping strategies to an escapable social stress
Neuropharmacology. 2024 Apr 16;252:109949. doi: 10.1016/j.neuropharm.2024.109949. Online ahead of print.ABSTRACTPsychedelic compounds have potentially rapid, long-lasting anxiolytic, antidepressive and anti-inflammatory effects. We investigated whether the psychedelic compound (R)-2,5-dimethoxy-4-iodoamphetamine [(R)-DOI], a selective 5-HT2A receptor partial agonist, decreases stress-related behavior in male mice exposed to repeated social aggression. Additionally, we explored the likelihood that these behavioral changes are related to anti-inflammatory properties of [(R)-DOI]. Animals were subjected to the Stress Alternat...
Source: Neuropharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Kevin T Krupp Jazmine D W Yaeger Leighton J Ledesma Miyuraj Harishchandra Hikkaduwa Withanage J J Gale Chase B Howe Trevor J Allen Monica Sathyanesan Samuel S Newton Cliff H Summers Source Type: research
Methylated urolithin A, mitigates cognitive impairment by inhibiting NLRP3 inflammasome and ameliorating mitochondrial dysfunction in aging mice
In conclusion, mUro A alleviates cognitive impairment in aging mice by suppressing neuroinflammation through NLRP3 inflammasome inhibition and restoring mitochondrial function via the p53-PGC-1α pathway. This suggests its potential therapeutic agent for brain aging and aging-related diseases.PMID:38636727 | DOI:10.1016/j.neuropharm.2024.109950 (Source: Neuropharmacology)
Source: Neuropharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Peng Chen Yulai Wang Jing Xie Jiexin Lei Benhong Zhou Source Type: research
Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity
Neuropharmacology. 2024 Apr 16:109948. doi: 10.1016/j.neuropharm.2024.109948. Online ahead of print.ABSTRACTAlcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and...
Source: Neuropharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Isabel Wank Claire Mittmann Silke Kreitz Daria Chestnykh Christiane M ühle Johannes Kornhuber Andreas Ludwig None Liubov S Kalinichenko Christian P M üller Andreas Hess Source Type: research
The small conductance Ca < sup > 2+ < /sup > -activated K < sup > + < /sup > channel activator GW542573X impairs hippocampal memory in C57BL/6J mice
Neuropharmacology. 2024 Apr 16;252:109960. doi: 10.1016/j.neuropharm.2024.109960. Online ahead of print.ABSTRACTSmall conductance Ca2+-activated K+ (SK) channels, expressed throughout the CNS, are comprised of SK1, SK2 and SK3 subunits, assembled as homotetrameric or heterotetrameric proteins. SK channels expressed somatically modulate the excitability of neurons by mediating the medium component of the afterhyperpolarization. Synaptic SK channels shape excitatory postsynaptic potentials and synaptic plasticity. Such SK-mediated effects on neuronal excitability and activity-dependent synaptic strength likely underlie the m...
Source: Neuropharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Claire A Rice Robert W Stackman Source Type: research
β-caryophyllene inhibits heroin self-administration, but does not alter opioid-induced antinociception in rodents
In this study, we found that systemic administration of BCP dose-dependently reduced heroin self-administration in rats under an FR2 schedule of reinforcement and partially blocked heroin-enhanced brain stimulation reward in DAT-cre mice, maintained by optical stimulation of midbrain dopamine neurons at high frequencies. Acute administration of BCP failed to block heroin conditioned place preference (CPP) in male mice, but attenuated heroin-induced CPP in females. Furthermore, repeated dosing with BCP for 5 days facilitated the extinction of CPP in female but not male mice. In the hot plate assay, pretreatment with the sam...
Source: Neuropharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Ewa Galaj Guo-Hua Bi Zheng-Xiong Xi Source Type: research
The small conductance Ca < sup > 2+ < /sup > -activated K < sup > + < /sup > channel activator GW542573X impairs hippocampal memory in C57BL/6J mice
Neuropharmacology. 2024 Apr 15:109960. doi: 10.1016/j.neuropharm.2024.109960. Online ahead of print.ABSTRACTSmall conductance Ca2+-activated K+ (SK) channels, expressed throughout the CNS, are comprised of SK1, SK2 and SK3 subunits, assembled as homotetrameric or heterotetrameric proteins. SK channels expressed somatically modulate the excitability of neurons by mediating the medium component of the afterhyperpolarization. Synaptic SK channels shape excitatory postsynaptic potentials and synaptic plasticity. Such SK-mediated effects on neuronal excitability and activity-dependent synaptic strength likely underlie the modul...
Source: Neuropharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Claire A Rice Robert W Stackman Source Type: research
β-caryophyllene inhibits heroin self-administration, but does not alter opioid-induced antinociception in rodents
In this study, we found that systemic administration of BCP dose-dependently reduced heroin self-administration in rats under an FR2 schedule of reinforcement and partially blocked heroin-enhanced brain stimulation reward in DAT-cre mice, maintained by optical stimulation of midbrain dopamine neurons at high frequencies. Acute administration of BCP failed to block heroin conditioned place preference (CPP) in male mice, but attenuated heroin-induced CPP in females. Furthermore, repeated dosing with BCP for 5 days facilitated the extinction of CPP in female but not male mice. In the hot plate assay, pretreatment with the sam...
Source: Neuropharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Ewa Galaj Guo-Hua Bi Zheng-Xiong Xi Source Type: research
Rethinking the role of microglia in obesity
Neuropharmacology. 2024 Apr 12:109951. doi: 10.1016/j.neuropharm.2024.109951. Online ahead of print.ABSTRACTMicroglia are the macrophages of the central nervous system (CNS), implying their role in maintaining brain homeostasis. To achieve this, these cells are sensitive to a plethora of endogenous and exogenous signals, such as neuronal activity, cellular debris, hormones, and pathological patterns, among many others. More recent research suggests that microglia are highly responsive to nutrients and dietary variations. In this context, numerous studies have demonstrated their significant role in the development of obesit...
Source: Neuropharmacology - April 14, 2024 Category: Drugs & Pharmacology Authors: G Cutugno E Kyriakidou A Nadjar Source Type: research
Rethinking the role of microglia in obesity
Neuropharmacology. 2024 Apr 12:109951. doi: 10.1016/j.neuropharm.2024.109951. Online ahead of print.ABSTRACTMicroglia are the macrophages of the central nervous system (CNS), implying their role in maintaining brain homeostasis. To achieve this, these cells are sensitive to a plethora of endogenous and exogenous signals, such as neuronal activity, cellular debris, hormones, and pathological patterns, among many others. More recent research suggests that microglia are highly responsive to nutrients and dietary variations. In this context, numerous studies have demonstrated their significant role in the development of obesit...
Source: Neuropharmacology - April 14, 2024 Category: Drugs & Pharmacology Authors: G Cutugno E Kyriakidou A Nadjar Source Type: research
