Retraction: miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer
J Cell Mol Med. 2024 Apr;28(8):e18314. doi: 10.1111/jcmm.18314.ABSTRACTZhi-Dong Lv, Bin Kong, Xiang-Ping Liu, Li-Ying Jin, Qian Dong, Fu-Nian Li, Hai-Bo Wang, miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer. Journal of Cellular and Molecular Medicine, 20: 864-873. https://doi.org/10.1111/jcmm.12770 The above article, published online on 28 January 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Stefan Constantinescu, The Foundation for Cellular and Molecular Medicine, and John...
Source: Molecular Medicine - April 24, 2024 Category: Molecular Biology Source Type: research
The tumor suppressor effect of miRNA 200-c-3p on A549 non-small cell lung cancer cell line is associated with down-regulation of programmed cell death ligand 1; an immune-check point mechanism
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):13-21. doi: 10.14715/cmb/2024.70.3.3.ABSTRACTMiRNA 200-c-3p has varying functions in different tumor types, whether tumor suppression or promotion. Comprehensive assessment of its function in non-small cell lung cancer (NSCLC) together with its effect on antitumor immune response have not been declared before. We aimed to explore the effect of replacement and suppression of miRNA 200-c-3p on non-small cell lung cancer and its impact on immune checkpoint function and subsequently antitumor immunity. MiRNA 200-c-3p mimic/inhibitor was transfected into the A549 cells. A 549 no...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Sara Ezzat None Magda I Mohamad None Manal Basyouni Ahmed None Sara Elsayed Abdelrahman None Nesma Hussein Abdel Hay None Nashwa El-Khazragy None Maha Imam Ismail Source Type: research
Retraction: Tanshinone IIA alleviates lipopolysaccharide-induced acute lung injury by downregulating TRPM7 and pro-inflammatory factors
J Cell Mol Med. 2024 Apr;28(8):e18313. doi: 10.1111/jcmm.18313.ABSTRACTJie Li, Yan Zheng, Ming-Xian Li, Chu-Wei Yang, Yu-Fei Liu, Tanshinone IIA alleviates lipopolysaccharide-induced acute lung injury by downregulating TRPM7 and pro-inflammatory factors. Journal of Cellular and Molecular Medicine, 22: 646-654. https://doi.org/10.1111/jcmm.13350 The above article, published online on 18 October 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by the journal Editor-in-Chief, Stefan Constantinescu, The Foundation for Cellular and Molecular Medicine, and John Wiley and Sons Ltd. The retraction has been...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Source Type: research
Macrophage-derived extracellular vesicles alter cardiac recovery and metabolism in a rat heart model of donation after circulatory death
J Cell Mol Med. 2024 Apr;28(8):e18281. doi: 10.1111/jcmm.18281.ABSTRACTConditions to which the cardiac graft is exposed during transplantation with donation after circulatory death (DCD) can trigger the recruitment of macrophages that are either unpolarized (M0) or pro-inflammatory (M1) as well as the release of extracellular vesicles (EV). We aimed to characterize the effects of M0 and M1 macrophage-derived EV administration on post-ischaemic functional recovery and glucose metabolism using an isolated rat heart model of DCD. Isolated rat hearts were subjected to 20 min aerobic perfusion, followed by 27 min global, warm i...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Selianne Graf Vanessa Biemmi Maria Arnold Adrian Segiser Anja M üller Natalia M éndez-Carmona Manuel Egle Matthias Siepe Lucio Barile Sarah Longnus Source Type: research
Identification of PPAR-related differentially expressed genes liver hepatocellular carcinoma and construction of a prognostic model based on data analysis and molecular docking
In this study, single-cell RNA sequencing (scRNA-seq) data were used to explore the molecular mechanisms of LIHC development and identify potential targets for therapy. The expression of peroxisome proliferator-activated receptors (PPAR)-related genes was analysed in LIHC samples, and primary cell populations, including natural killer cells, T cells, B cells, myeloid cells, endothelial cells, fibroblasts and hepatocytes, were identified. Analysis of the differentially expressed genes (DEGs) between normal and tumour tissues revealed significant changes in gene expression in various cell populations. PPAR activity was evalu...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Yumeng Wang Shuqiang Li Zihang Liu Xuanzheng Li Yifan Yu Hao Liu Source Type: research
Non-apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages
J Cell Mol Med. 2024 Apr;28(8):e18348. doi: 10.1111/jcmm.18348.ABSTRACTTumour immune microenvironment (TIME) plays an indispensable role in tumour progression, and tumour-associated macrophages (TAMs) are the most abundant immune cells in TIME. Non-apoptotic regulated cell death (RCD) can avoid the influence of tumour apoptosis resistance on anti-tumour immune response. Specifically, autophagy, ferroptosis, pyroptosis and necroptosis mediate the crosstalk between TAMs and tumour cells in TIME, thus reprogram TIME and affect the progress of tumour. In addition, although some achievements have been made in immune checkpoint ...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Chengpeng Sun Jianhao Zhan Yao Li Chulin Zhou Shuo Huang Xingen Zhu Kai Huang Source Type: research
An integrated analysis of the anticarcinogenic role of forkhead box protein 1 in oesophageal squamous cell carcinoma
This study investigated the role of FOXP1 in oesophageal squamous cell carcinoma through bioinformatics analysis and experimental verification. We determined through public databases that FOXP1 expresses low in oesophageal squamous cell carcinoma compared with normal tissues, while high expression of FOXP1 indicates a better prognosis. We identified potential target genes regulated by FOXP1, and explored the potential biological processes and signalling pathways involved in FOXP1 in oesophageal squamous cell carcinoma through GO and KEGG enrichment, gene co-expression analysis, and protein interaction network construction....
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Guanzhi Ye Gaojian Pan Xiaolei Zhu Ning Li Hongming Liu Guojun Geng Jie Jiang Source Type: research
Proteomic studies in VWA1-related neuromyopathy allowed new pathophysiological insights and the definition of blood biomarkers
J Cell Mol Med. 2024 Apr;28(8):e18122. doi: 10.1111/jcmm.18122.ABSTRACTBi-allelic variants in VWA1, encoding Von Willebrand Factor A domain containing 1 protein localized to the extracellular matrix (ECM), were linked to a neuromuscular disorder with manifestation in child- or adulthood. Clinical findings indicate a neuromyopathy presenting with muscle weakness. Given that pathophysiological processes are still incompletely understood, and biomarkers are still missing, we aimed to identify blood biomarkers of pathophysiological relevance: white blood cells (WBC) and plasma derived from six VWA1-patients were investigated b...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Mohammed Athamneh Nassam Daya Andreas Hentschel Andrea Gangfuss Tobias Ruck Adela Della Marina Ulrike Schara-Schmidt Albert Sickmann Anne-Katrin G üttsches Marcus Deschauer Corinna Preusse Matthias Vorgerd Andreas Roos Source Type: research
Interplay of precision therapeutics and MD study: Calocybe indica's potentials against cervical cancer and its interaction with VEGF via octadecanoic acid
This study offers a holistic perspective on the promising therapeutic avenues facilitated by C. indica against cervical cancer, intricately woven with advanced molecular interactions and the prospective integration of precision therapeutics in modern oncology.PMID:38652115 | PMC:PMC11037404 | DOI:10.1111/jcmm.18302 (Source: Molecular Medicine)
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Suhana Datta Preeti Verma Bikram Dhara Rita Kundu Swastika Maitra Arup Kumar Mitra Mohd Shahnawaz Khan Torki A Zughaibi Shams Tabrez Ajoy Kumer Source Type: research
Rapid discrimination of four Salmonella enterica serovars: A performance comparison between benchtop and handheld Raman spectrometers
This study demonstrated that handheld Raman spectrometers achieved similar prediction accuracy as benchtop spectrometers when combined with machine learning models, providing an effective solution for rapid, accurate and cost-effective identification of closely associated S. enterica serovars.PMID:38652116 | PMC:PMC11037414 | DOI:10.1111/jcmm.18292 (Source: Molecular Medicine)
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Quan Yuan Bin Gu Wei Liu Xin-Ru Wen Ji-Liang Wang Jia-Wei Tang Muhammad Usman Su-Ling Liu Yu-Rong Tang Liang Wang Source Type: research
Bortezomib suppresses acute myelogenous leukaemia stem-like KG-1a cells via NF- κB inhibition and the induction of oxidative stress
J Cell Mol Med. 2024 Apr;28(8):e18333. doi: 10.1111/jcmm.18333.ABSTRACTAcute myelogenous leukaemia (AML) originates and is maintained by leukaemic stem cells (LSCs) that are inherently resistant to antiproliferative therapies, indicating that a critical strategy for overcoming chemoresistance in AML therapy is to eradicate LSCs. In this work, we investigated the anti-AML activity of bortezomib (BTZ), emphasizing its anti-LSC potential, using KG-1a cells, an AML cell line with stem-like properties. BTZ presented potent cytotoxicity to both solid and haematological malignancy cells and reduced the stem-like features of KG-1a...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Rafaela G A Costa Maiara de S Oliveira Ana Carolina B da C Rodrigues Suellen L R Silva Ingrid R S B Dias Milena B P Soares Ludmila de Faro Valverde Clarissa Araujo Gurgel Rocha Rosane Borges Dias Daniel P Bezerra Source Type: research
The β3-AR agonist BRL37344 ameliorates the main symptoms of X-linked nephrogenic diabetes insipidus in the mouse model of the disease
J Cell Mol Med. 2024 Apr;28(8):e18301. doi: 10.1111/jcmm.18301.ABSTRACTX-linked nephrogenic diabetes insipidus (X-NDI) is a rare congenital disease caused by inactivating mutations of the vasopressin type-2 receptor (AVPR2), characterized by impaired renal concentrating ability, dramatic polyuria, polydipsia and risk of dehydration. The disease, which still lacks a cure, could benefit from the pharmacologic stimulation of other GPCRs, activating the cAMP-intracellular pathway in the kidney cells expressing the AVPR2. On the basis of our previous studies, we here hypothesized that the β3-adrenergic receptor could be such a...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Serena Milano Ilenia Saponara Andrea Gerbino Monica Carmosino Maria Svelto Giuseppe Procino Source Type: research
Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4-xCT pathway
J Cell Mol Med. 2024 Apr;28(8):e18335. doi: 10.1111/jcmm.18335.ABSTRACTManagement of hepatocellular carcinoma (HCC) remains challenging due to population growth, frequent recurrence and drug resistance. Targeting of genes involved with the ferroptosis is a promising alternative treatment strategy for HCC. The present study aimed to investigate the effect of dihydroartemisinin (DHA) against HCC and explore the underlying mechanisms. The effects of DHA on induction of ferroptosis were investigated with the measurement of malondialdehyde concentrations, oxidised C11 BODIPY 581/591 staining, as well as subcutaneous xenograft e...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Jie Ji Ziqi Cheng Jie Zhang Jianye Wu Xuanfu Xu Chuanyong Guo Jiao Feng Source Type: research
MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2
This study demonstrated that MELK aggravated LUAD by upregulating EZH2 and downregulating LATS2.PMID:38652219 | PMC:PMC11037405 | DOI:10.1111/jcmm.18216 (Source: Molecular Medicine)
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Hui Yu Xianrong Xu Lirong Zhu Shengjie Chen Jincheng He Source Type: research
RNA-mediated epigenetic regulation in exercised heart: Mechanisms and opportunities for intervention
Mol Aspects Med. 2024 Apr 22;97:101274. doi: 10.1016/j.mam.2024.101274. Online ahead of print.ABSTRACTPhysical exercise has been widely acknowledged as a beneficial lifestyle alteration and a potent non-pharmacological treatment for heart disease. Extensive investigations have revealed the beneficial effects of exercise on the heart and the underlying mechanisms involved. Exercise is considered one of the key factors that can lead to epigenetic alterations. The increasing number of identified molecules in the exercised heart has led to many studies in recent years that have explored the cellular function of ncRNAs and RNA ...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Lijun Wang Wensi Wan Shuang Zhang Tarun Keswani Guoping Li Junjie Xiao Source Type: research
