Unravelling CD4 < sup > + < /sup > T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing
Immunology. 2024 Apr 18. doi: 10.1111/imm.13796. Online ahead of print.ABSTRACTImmune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown. Using single-cell RNA sequencing (scRNA-seq) on CD4+ T cells from the AAA aorta and spleen, we discovered heterogeneity among CD4+ T cells and identified...
Source: Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Luna Zhai Wangling Hu Jingyong Li Dan Li Ni Xia Tingting Tang Shaofang Nie Min Zhang Jiao Jiao Bingjie Lv Fen Yang Yuzhi Lu Lingfeng Zha Muyang Gu Xiajun Hu Shuang Wen Desheng Hu Li Zhang Weimin Wang Xiang Cheng Source Type: research
Unravelling CD4 < sup > + < /sup > T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing
Immunology. 2024 Apr 18. doi: 10.1111/imm.13796. Online ahead of print.ABSTRACTImmune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown. Using single-cell RNA sequencing (scRNA-seq) on CD4+ T cells from the AAA aorta and spleen, we discovered heterogeneity among CD4+ T cells and identified...
Source: Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Luna Zhai Wangling Hu Jingyong Li Dan Li Ni Xia Tingting Tang Shaofang Nie Min Zhang Jiao Jiao Bingjie Lv Fen Yang Yuzhi Lu Lingfeng Zha Muyang Gu Xiajun Hu Shuang Wen Desheng Hu Li Zhang Weimin Wang Xiang Cheng Source Type: research
Oligodeoxynucleotides containing CpG motifs (CpG-ODN) restores immune regulatory functions of airway macrophages of patients with asthma
In conclusion, the induction of IL-10 in macrophages of BALF in asthma patients was impaired, and it could be restored by exposure to CpG.PMID:38634546 | DOI:10.1111/imm.13792 (Source: Immunology)
Source: Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Huanping Zhang Lihuan Wang Aizhi Zhang Xiangyu Wang Yun Liao Xiaoxue Chen Xuejie Xu Litao Yang Yu Liu Aifa Tang Pingchang Yang Source Type: research
TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS
In this study, the pro-inflammatory roles of TLR7/TLR8-activating miRs were examined as mediators of FM inflammation in response to bacterial lipopolysaccharide (LPS) using an in vitro human FM explant system, an in vivo mouse model of pregnancy, and human clinical samples. Following LPS exposure, miR-146a-3p was significantly increased in both human FM explants and wild-type mouse FMs. Expression of miR-146a-3p was also significantly elevated in FMs from women with preterm birth and chorioamnionitis. FM IL-8 and inflammasome-mediated IL-1β production in response to LPS was dependent on miR-146a-3p and TLR8 downstream of ...
Source: Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Hanah M Georges Caterina Cassin Mancy Tong Vikki M Abrahams Source Type: research
TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS
In this study, the pro-inflammatory roles of TLR7/TLR8-activating miRs were examined as mediators of FM inflammation in response to bacterial lipopolysaccharide (LPS) using an in vitro human FM explant system, an in vivo mouse model of pregnancy, and human clinical samples. Following LPS exposure, miR-146a-3p was significantly increased in both human FM explants and wild-type mouse FMs. Expression of miR-146a-3p was also significantly elevated in FMs from women with preterm birth and chorioamnionitis. FM IL-8 and inflammasome-mediated IL-1β production in response to LPS was dependent on miR-146a-3p and TLR8 downstream of ...
Source: Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Hanah M Georges Caterina Cassin Mancy Tong Vikki M Abrahams Source Type: research
Immunotherapy and the ovarian cancer microenvironment: Exploring potential strategies for enhanced treatment efficacy
Immunology. 2024 Apr 15. doi: 10.1111/imm.13793. Online ahead of print.ABSTRACTDespite progress in cancer immunotherapy, ovarian cancer (OC) prognosis continues to be disappointing. Recent studies have shed light on how not just tumour cells, but also the complex tumour microenvironment, contribute to this unfavourable outcome of OC immunotherapy. The complexities of the immune microenvironment categorize OC as a 'cold tumour'. Nonetheless, understanding the precise mechanisms through which the microenvironment influences the effectiveness of OC immunotherapy remains an ongoing scientific endeavour. This review primarily a...
Source: Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Zhi-Bin Wang Xiu Zhang Chao Fang Xiao-Ting Liu Qian-Jin Liao Nayiyuan Wu Jing Wang Source Type: research
The TRIF-RIPK1-Caspase-8 signalling in the regulation of TLR4-driven gene expression
Immunology. 2024 Apr 15. doi: 10.1111/imm.13795. Online ahead of print.ABSTRACTThe inflammatory response is tightly regulated to eliminate invading pathogens and avoid excessive production of inflammatory mediators and tissue damage. Caspase-8 is a cysteine protease that is involved in programmed cell death. Here we show the TRIF-RIPK1-Caspase-8 is required for LPS-induced CYLD degradation in macrophages. TRIF functions in the upstream of RIPK1. The homotypic interaction motif of TRIF and the death domain of RIPK1 are essential for Caspase-8 activation. Caspase-8 cleaves CYLD and the D235A mutant is resistant to the protea...
Source: Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Chengyang Zhang Yang Zhou Shuangtong Xi Danlin Han Ziyu Wang Jingwen Zhu Yizhe Cai Haifeng Zhang Ge Jin Yang Mi Source Type: research
Immunotherapy and the ovarian cancer microenvironment: Exploring potential strategies for enhanced treatment efficacy
Immunology. 2024 Apr 15. doi: 10.1111/imm.13793. Online ahead of print.ABSTRACTDespite progress in cancer immunotherapy, ovarian cancer (OC) prognosis continues to be disappointing. Recent studies have shed light on how not just tumour cells, but also the complex tumour microenvironment, contribute to this unfavourable outcome of OC immunotherapy. The complexities of the immune microenvironment categorize OC as a 'cold tumour'. Nonetheless, understanding the precise mechanisms through which the microenvironment influences the effectiveness of OC immunotherapy remains an ongoing scientific endeavour. This review primarily a...
Source: Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Zhi-Bin Wang Xiu Zhang Chao Fang Xiao-Ting Liu Qian-Jin Liao Nayiyuan Wu Jing Wang Source Type: research
The TRIF-RIPK1-Caspase-8 signalling in the regulation of TLR4-driven gene expression
Immunology. 2024 Apr 15. doi: 10.1111/imm.13795. Online ahead of print.ABSTRACTThe inflammatory response is tightly regulated to eliminate invading pathogens and avoid excessive production of inflammatory mediators and tissue damage. Caspase-8 is a cysteine protease that is involved in programmed cell death. Here we show the TRIF-RIPK1-Caspase-8 is required for LPS-induced CYLD degradation in macrophages. TRIF functions in the upstream of RIPK1. The homotypic interaction motif of TRIF and the death domain of RIPK1 are essential for Caspase-8 activation. Caspase-8 cleaves CYLD and the D235A mutant is resistant to the protea...
Source: Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Chengyang Zhang Yang Zhou Shuangtong Xi Danlin Han Ziyu Wang Jingwen Zhu Yizhe Cai Haifeng Zhang Ge Jin Yang Mi Source Type: research
Homotherapy for heteropathy: Interleukin-41 and its biological functions
Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print.ABSTRACTInterleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Grav...
Source: Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Runfeng Shi Meixin He Yongzheng Peng Xu Xia Source Type: research
Homotherapy for heteropathy: Interleukin-41 and its biological functions
Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print.ABSTRACTInterleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Grav...
Source: Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Runfeng Shi Meixin He Yongzheng Peng Xu Xia Source Type: research
Homotherapy for heteropathy: Interleukin-41 and its biological functions
Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print.ABSTRACTInterleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Grav...
Source: Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Runfeng Shi Meixin He Yongzheng Peng Xu Xia Source Type: research
Homotherapy for heteropathy: Interleukin-41 and its biological functions
Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print.ABSTRACTInterleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Grav...
Source: Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Runfeng Shi Meixin He Yongzheng Peng Xu Xia Source Type: research
Homotherapy for heteropathy: Interleukin-41 and its biological functions
Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print.ABSTRACTInterleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Grav...
Source: Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Runfeng Shi Meixin He Yongzheng Peng Xu Xia Source Type: research
CXCR3 < sup > + < /sup > effector regulatory T cells associate with disease tolerance during lower respiratory pneumovirus infection
Immunology. 2024 Apr 7. doi: 10.1111/imm.13790. Online ahead of print.ABSTRACTLifestyle factors like poor maternal diet or antibiotic exposure disrupt early life microbiome assembly in infants, increasing the risk of severe lower respiratory infections (sLRI). Our prior studies in mice indicated that a maternal low-fibre diet (LFD) exacerbates LRI severity in infants by impairing recruitment of plasmacytoid dendritic cells (pDC) and consequently attenuating expansion of lung regulatory T (Treg) cells during pneumonia virus of mice (PVM) infection. Here, we investigated whether maternal dietary fibre intake influences Treg ...
Source: Immunology - April 7, 2024 Category: Allergy & Immunology Authors: Ismail Sebina Sylvia Ngo Ridwan B Rashid Mariah Alorro Patricia Namubiru Daniel Howard Tufael Ahmed Simon Phipps Source Type: research
