The soluble IL-2 receptor α/CD25 as a modulator of IL-2 function
We describe the molecular mechanisms leading to sIL-2Rα generation and discuss the different IL-2 modulating functions that have been attributed to the sIL-2Rα. Finally, we describe attempts to utilize the sIL-2Rα as a therapeutic tool.PMID:38037265 | DOI:10.1111/imm.13723 (Source: Immunology)
Source: Immunology - December 1, 2023 Category: Allergy & Immunology Authors: Juliane Lokau Lynn M Petasch Christoph Garbers Source Type: research
The soluble IL-2 receptor α/CD25 as a modulator of IL-2 function
We describe the molecular mechanisms leading to sIL-2Rα generation and discuss the different IL-2 modulating functions that have been attributed to the sIL-2Rα. Finally, we describe attempts to utilize the sIL-2Rα as a therapeutic tool.PMID:38037265 | DOI:10.1111/imm.13723 (Source: Immunology)
Source: Immunology - December 1, 2023 Category: Allergy & Immunology Authors: Juliane Lokau Lynn M Petasch Christoph Garbers Source Type: research
The soluble IL-2 receptor α/CD25 as a modulator of IL-2 function
We describe the molecular mechanisms leading to sIL-2Rα generation and discuss the different IL-2 modulating functions that have been attributed to the sIL-2Rα. Finally, we describe attempts to utilize the sIL-2Rα as a therapeutic tool.PMID:38037265 | DOI:10.1111/imm.13723 (Source: Immunology)
Source: Immunology - December 1, 2023 Category: Allergy & Immunology Authors: Juliane Lokau Lynn M Petasch Christoph Garbers Source Type: research
The soluble IL-2 receptor α/CD25 as a modulator of IL-2 function
We describe the molecular mechanisms leading to sIL-2Rα generation and discuss the different IL-2 modulating functions that have been attributed to the sIL-2Rα. Finally, we describe attempts to utilize the sIL-2Rα as a therapeutic tool.PMID:38037265 | DOI:10.1111/imm.13723 (Source: Immunology)
Source: Immunology - December 1, 2023 Category: Allergy & Immunology Authors: Juliane Lokau Lynn M Petasch Christoph Garbers Source Type: research
The soluble IL-2 receptor α/CD25 as a modulator of IL-2 function
We describe the molecular mechanisms leading to sIL-2Rα generation and discuss the different IL-2 modulating functions that have been attributed to the sIL-2Rα. Finally, we describe attempts to utilize the sIL-2Rα as a therapeutic tool.PMID:38037265 | DOI:10.1111/imm.13723 (Source: Immunology)
Source: Immunology - December 1, 2023 Category: Allergy & Immunology Authors: Juliane Lokau Lynn M Petasch Christoph Garbers Source Type: research
Probiotic Bacillus spp. enhance TLR3-mediated TNF signalling in macrophages
Immunology. 2023 Nov 29. doi: 10.1111/imm.13721. Online ahead of print.ABSTRACTProbiotics have been reported to have immunomodulatory properties in the context of infectious disease and inflammation, although the underlying mechanisms are not fully understood. Here, we aimed to determine how different probiotic bacterial strains modulated macrophage function during TLR3 stimulation mimicking viral infection. We screened 14 different strains for their ability to modulate TNF-α, IL-6 IL-10, IFN-α, IFN-β and IFN-γ secretion in RAW 264.7 macrophages with or without poly(I:C) stimulation. Seven strains were selected for fur...
Source: Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Katrine Damgaard Winther Erik Juncker Boll Dorthe Sandvang Andrew R Williams Source Type: research
Probiotic Bacillus spp. enhance TLR3-mediated TNF signalling in macrophages
Immunology. 2023 Nov 29. doi: 10.1111/imm.13721. Online ahead of print.ABSTRACTProbiotics have been reported to have immunomodulatory properties in the context of infectious disease and inflammation, although the underlying mechanisms are not fully understood. Here, we aimed to determine how different probiotic bacterial strains modulated macrophage function during TLR3 stimulation mimicking viral infection. We screened 14 different strains for their ability to modulate TNF-α, IL-6 IL-10, IFN-α, IFN-β and IFN-γ secretion in RAW 264.7 macrophages with or without poly(I:C) stimulation. Seven strains were selected for fur...
Source: Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Katrine Damgaard Winther Erik Juncker Boll Dorthe Sandvang Andrew R Williams Source Type: research
Roles of S100A8, S100A9 and S100A12 in infection, inflammation and immunity
This article summarizes the structure and function of the proteins S100A8, S100A9 and S100A12 and lays the foundation for further understanding their roles in infection, immunity and inflammation, as well as their potential applications in the prevention and treatment of infectious diseases.PMID:38013255 | DOI:10.1111/imm.13722 (Source: Immunology)
Source: Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Pengpeng Xia Xingduo Ji Li Yan Siqi Lian Ziyue Chen Yi Luo Source Type: research
Roles of S100A8, S100A9 and S100A12 in infection, inflammation and immunity
This article summarizes the structure and function of the proteins S100A8, S100A9 and S100A12 and lays the foundation for further understanding their roles in infection, immunity and inflammation, as well as their potential applications in the prevention and treatment of infectious diseases.PMID:38013255 | DOI:10.1111/imm.13722 (Source: Immunology)
Source: Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Pengpeng Xia Xingduo Ji Li Yan Siqi Lian Ziyue Chen Yi Luo Source Type: research
Applications of single-cell omics for chimeric antigen receptor T cell therapy
Immunology. 2023 Nov 27. doi: 10.1111/imm.13720. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment modality. The breakthroughs in CAR T cell therapy were, in part, possible with the help of cell analysis methods, such as single-cell analysis. Bulk analyses have provided invaluable information regarding the complex molecular dynamics of CAR T cells, but their results are an average of thousands of signals in CAR T or tumour cells. Since cancer is a heterogeneous disease where each minute detail of a subclone could change the outcome of the treatment, single-cell ana...
Source: Immunology - November 27, 2023 Category: Allergy & Immunology Authors: Sasan Ghaffari Mahshid Saleh Behnia Akbari Faezeh Ramezani Hamid Reza Mirzaei Source Type: research
Melanoma tumour-derived glycans hijack dendritic cell subsets through C-type lectin receptor binding
We examined the ability of glycans to bind to purified DCs, and assessed their impact on DC basal properties and functional features using flow cytometry, confocal microscopy and multiplex secreted protein analysis. DC subsets differentially bound and internalised NeoGP depending on the nature of the glycan. Strikingly, Fuc directly remodelled the expression of activation markers and immune checkpoints, as well as the cytokine/chemokine secretion profile of DC subsets. NeoGP interfered with Toll like receptor (TLR)-signalling and pre-conditioned DCs to exhibit an altered response to subsequent TLR stimulation, dampening an...
Source: Immunology - November 22, 2023 Category: Allergy & Immunology Authors: Camille Niveau Eleonora Sosa Cuevas Beno ît Roubinet Myl ène Pezet Michel Th épaut St éphane Mouret Julie Charles Franck Fieschi Ludovic Landemarre Laurence Chaperot Philippe Saas Caroline Aspord Source Type: research
Melanoma tumour-derived glycans hijack dendritic cell subsets through C-type lectin receptor binding
We examined the ability of glycans to bind to purified DCs, and assessed their impact on DC basal properties and functional features using flow cytometry, confocal microscopy and multiplex secreted protein analysis. DC subsets differentially bound and internalised NeoGP depending on the nature of the glycan. Strikingly, Fuc directly remodelled the expression of activation markers and immune checkpoints, as well as the cytokine/chemokine secretion profile of DC subsets. NeoGP interfered with Toll like receptor (TLR)-signalling and pre-conditioned DCs to exhibit an altered response to subsequent TLR stimulation, dampening an...
Source: Immunology - November 22, 2023 Category: Allergy & Immunology Authors: Camille Niveau Eleonora Sosa Cuevas Beno ît Roubinet Myl ène Pezet Michel Th épaut St éphane Mouret Julie Charles Franck Fieschi Ludovic Landemarre Laurence Chaperot Philippe Saas Caroline Aspord Source Type: research
Melanoma tumour-derived glycans hijack dendritic cell subsets through C-type lectin receptor binding
We examined the ability of glycans to bind to purified DCs, and assessed their impact on DC basal properties and functional features using flow cytometry, confocal microscopy and multiplex secreted protein analysis. DC subsets differentially bound and internalised NeoGP depending on the nature of the glycan. Strikingly, Fuc directly remodelled the expression of activation markers and immune checkpoints, as well as the cytokine/chemokine secretion profile of DC subsets. NeoGP interfered with Toll like receptor (TLR)-signalling and pre-conditioned DCs to exhibit an altered response to subsequent TLR stimulation, dampening an...
Source: Immunology - November 22, 2023 Category: Allergy & Immunology Authors: Camille Niveau Eleonora Sosa Cuevas Beno ît Roubinet Myl ène Pezet Michel Th épaut St éphane Mouret Julie Charles Franck Fieschi Ludovic Landemarre Laurence Chaperot Philippe Saas Caroline Aspord Source Type: research
Melanoma tumour-derived glycans hijack dendritic cell subsets through C-type lectin receptor binding
We examined the ability of glycans to bind to purified DCs, and assessed their impact on DC basal properties and functional features using flow cytometry, confocal microscopy and multiplex secreted protein analysis. DC subsets differentially bound and internalised NeoGP depending on the nature of the glycan. Strikingly, Fuc directly remodelled the expression of activation markers and immune checkpoints, as well as the cytokine/chemokine secretion profile of DC subsets. NeoGP interfered with Toll like receptor (TLR)-signalling and pre-conditioned DCs to exhibit an altered response to subsequent TLR stimulation, dampening an...
Source: Immunology - November 22, 2023 Category: Allergy & Immunology Authors: Camille Niveau Eleonora Sosa Cuevas Beno ît Roubinet Myl ène Pezet Michel Th épaut St éphane Mouret Julie Charles Franck Fieschi Ludovic Landemarre Laurence Chaperot Philippe Saas Caroline Aspord Source Type: research
New sights of low dose IL-2: Restoration of immune homeostasis for viral infection
In conclusion, focusing on the role of ld-IL-2 in viral infections may provide a new perspective for regulating immune responses following viral infections and improving prognosis.PMID:37985960 | DOI:10.1111/imm.13719 (Source: Immunology)
Source: Immunology - November 21, 2023 Category: Allergy & Immunology Authors: Rui Su Tingting Zhang Hui Wang Gaofei Yan Ruihe Wu Xin Zhang Chong Gao Xiaofeng Li Caihong Wang Source Type: research
