Unravelling CD4 < sup > + < /sup > T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing

Immunology. 2024 Apr 18. doi: 10.1111/imm.13796. Online ahead of print.ABSTRACTImmune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown. Using single-cell RNA sequencing (scRNA-seq) on CD4+ T cells from the AAA aorta and spleen, we discovered heterogeneity among CD4+ T cells and identified activated, proliferating and developed aorta Tregs. These Tregs originate in the peripheral tissues and acquire the tissue-specific phenotype in the aorta. The identification of precursors for Tregs in AAA provides new insight into the pathogenesis of AAA.PMID:38637948 | DOI:10.1111/imm.13796

Source: Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Luna Zhai Wangling Hu Jingyong Li Dan Li Ni Xia Tingting Tang Shaofang Nie Min Zhang Jiao Jiao Bingjie Lv Fen Yang Yuzhi Lu Lingfeng Zha Muyang Gu Xiajun Hu Shuang Wen Desheng Hu Li Zhang Weimin Wang Xiang Cheng Source Type: research