New sights of low dose IL-2: Restoration of immune homeostasis for viral infection
In conclusion, focusing on the role of ld-IL-2 in viral infections may provide a new perspective for regulating immune responses following viral infections and improving prognosis.PMID:37985960 | DOI:10.1111/imm.13719 (Source: Immunology)
Source: Immunology - November 21, 2023 Category: Allergy & Immunology Authors: Rui Su Tingting Zhang Hui Wang Gaofei Yan Ruihe Wu Xin Zhang Chong Gao Xiaofeng Li Caihong Wang Source Type: research
Tregs protect against invariant NKT cell-mediated autoimmune colitis and hepatitis
Immunology. 2023 Nov 20. doi: 10.1111/imm.13718. Online ahead of print.ABSTRACTImmunomodulatory T cells play a pivotal role in protection against (auto)immune-mediated diseases that open perspectives for therapeutic modulation. However, how immune regulatory networks operate in vivo is less understood. To this end, we focused on FOXP3+CD4+CD25+ regulatory T cells (Tregs) and invariant natural killer T (iNKT) cells, two lymphocyte populations that independently regulate adaptive and innate immune responses. In vitro, a functional interplay between Tregs and iNKT cells has been described, but whether Tregs modulate the funct...
Source: Immunology - November 20, 2023 Category: Allergy & Immunology Authors: Koen Venken Tine Decruy Tim Sparwasser Dirk Elewaut Source Type: research
Correlation between antibodies against the pathogenic pHERV-W envelope protein and the inflammatory phase of multiple sclerosis
This study aimed to investigate the humoral response to syncytin-1 and pHERV-W-derived peptides in a group of relapsing remitting MS patients categorized as having acute or stable disease. Furthermore, an inhibition assay was conducted to assess the extent of cross-reactivity between the two epitopes. The findings revealed that MS patients in the acute phase exhibited a higher specific antibody response to the pHERV-W env epitope compared to syncytin-1. This suggests a potential pathogenic role for pHERV-W env during the inflammatory stages of central nervous system involvement, and these antibody responses could serve as ...
Source: Immunology - November 20, 2023 Category: Allergy & Immunology Authors: Stefano Ruberto Davide Cossu Leonardo A Sechi Source Type: research
Macrophage-like rapid uptake and toxicity of tattoo ink in human monocytes
Immunology. 2023 Nov 14. doi: 10.1111/imm.13714. Online ahead of print.ABSTRACTMacrophages play a critical role for the persistence of tattoo ink in human skin. However, a comparison to other skin-resident and blood circulating immune cells and a profound analysis of REACH-compliant tattoo ink are unmet medical needs. We hence characterized the size distribution of ink particles using physicochemical methods. We studied the uptake of tattoo ink by key human skin cells and blood-derived immune cells using optical and electron microscopy as well as flow cytometry. Scanning electron microscopy of ink revealed its crystalline ...
Source: Immunology - November 15, 2023 Category: Allergy & Immunology Authors: Cheng Lin Yvonne Marquardt Stefan R ütten Liangliang Liao Khosrow Rahimi Tamas Haraszti Jens Malte Baron Matthias Bartneck Source Type: research
Macrophage-like rapid uptake and toxicity of tattoo ink in human monocytes
Immunology. 2023 Nov 14. doi: 10.1111/imm.13714. Online ahead of print.ABSTRACTMacrophages play a critical role for the persistence of tattoo ink in human skin. However, a comparison to other skin-resident and blood circulating immune cells and a profound analysis of REACH-compliant tattoo ink are unmet medical needs. We hence characterized the size distribution of ink particles using physicochemical methods. We studied the uptake of tattoo ink by key human skin cells and blood-derived immune cells using optical and electron microscopy as well as flow cytometry. Scanning electron microscopy of ink revealed its crystalline ...
Source: Immunology - November 15, 2023 Category: Allergy & Immunology Authors: Cheng Lin Yvonne Marquardt Stefan R ütten Liangliang Liao Khosrow Rahimi Tamas Haraszti Jens Malte Baron Matthias Bartneck Source Type: research
Macrophage-like rapid uptake and toxicity of tattoo ink in human monocytes
Immunology. 2023 Nov 14. doi: 10.1111/imm.13714. Online ahead of print.ABSTRACTMacrophages play a critical role for the persistence of tattoo ink in human skin. However, a comparison to other skin-resident and blood circulating immune cells and a profound analysis of REACH-compliant tattoo ink are unmet medical needs. We hence characterized the size distribution of ink particles using physicochemical methods. We studied the uptake of tattoo ink by key human skin cells and blood-derived immune cells using optical and electron microscopy as well as flow cytometry. Scanning electron microscopy of ink revealed its crystalline ...
Source: Immunology - November 15, 2023 Category: Allergy & Immunology Authors: Cheng Lin Yvonne Marquardt Stefan R ütten Liangliang Liao Khosrow Rahimi Tamas Haraszti Jens Malte Baron Matthias Bartneck Source Type: research
Macrophage-like rapid uptake and toxicity of tattoo ink in human monocytes
Immunology. 2023 Nov 14. doi: 10.1111/imm.13714. Online ahead of print.ABSTRACTMacrophages play a critical role for the persistence of tattoo ink in human skin. However, a comparison to other skin-resident and blood circulating immune cells and a profound analysis of REACH-compliant tattoo ink are unmet medical needs. We hence characterized the size distribution of ink particles using physicochemical methods. We studied the uptake of tattoo ink by key human skin cells and blood-derived immune cells using optical and electron microscopy as well as flow cytometry. Scanning electron microscopy of ink revealed its crystalline ...
Source: Immunology - November 15, 2023 Category: Allergy & Immunology Authors: Cheng Lin Yvonne Marquardt Stefan R ütten Liangliang Liao Khosrow Rahimi Tamas Haraszti Jens Malte Baron Matthias Bartneck Source Type: research
Macrophage-like rapid uptake and toxicity of tattoo ink in human monocytes
Immunology. 2023 Nov 14. doi: 10.1111/imm.13714. Online ahead of print.ABSTRACTMacrophages play a critical role for the persistence of tattoo ink in human skin. However, a comparison to other skin-resident and blood circulating immune cells and a profound analysis of REACH-compliant tattoo ink are unmet medical needs. We hence characterized the size distribution of ink particles using physicochemical methods. We studied the uptake of tattoo ink by key human skin cells and blood-derived immune cells using optical and electron microscopy as well as flow cytometry. Scanning electron microscopy of ink revealed its crystalline ...
Source: Immunology - November 15, 2023 Category: Allergy & Immunology Authors: Cheng Lin Yvonne Marquardt Stefan R ütten Liangliang Liao Khosrow Rahimi Tamas Haraszti Jens Malte Baron Matthias Bartneck Source Type: research
Splenocytes with fucosylation deficiency promote T cell proliferation and differentiation through thrombospondin-1 downregulation
In this study, we aimed to explore the transcriptome profiles of splenocytes deficient in fucosyltransferase (FUT) 1, an enzyme that mediates fucosylation, and investigate their impact on the proliferation and differentiation of T cells. We analysed and compared the transcriptomes of splenocytes isolated from Fut1 knockout (KO) mice and those from wild-type (WT) mice using RNA-seq. Additionally, we examined the effects of Fut1 KO splenocytes on CD4 T cell proliferation and differentiation, in comparison to WT splenocytes, and elucidated the mechanisms involved. The comparative analysis of transcriptomes between Fut1 KO and...
Source: Immunology - November 14, 2023 Category: Allergy & Immunology Authors: Jung Hwa Ko Jin Suk Ryu Jang-Hee Oh Joo Youn Oh Source Type: research
Intratracheal administration of cross-linked water-soluble acrylic acid polymer is associated with inducible bronchi-related lymphoid tissue formation and allergic inflammation
In this study, we investigated the effects of multiple intratracheal administrations of CWAAP on inflammatory responses and pulmonary fibrosis along with inducible bronchus-associated lymphoid tissues (iBALT) formation, which is involved in allergic inflammation. Male F344 rats (190-200 g) received single or multiple intratracheal administrations of phosphate-buffered saline (PBS) or CWAAP. To assess inflammatory responses and pulmonary fibrosis, immunohistochemical and histological staining was performed. CD68, CD163, CD169, TGF-β, and collagen I positive cells/areas in the lungs of the CWAAP-group rats were significantl...
Source: Immunology - November 14, 2023 Category: Allergy & Immunology Authors: Takamasa Kido Chiemi Sugaya Hiroshi Hano Hiroyuki Yanagisawa Machi Suka Source Type: research
Splenocytes with fucosylation deficiency promote T cell proliferation and differentiation through thrombospondin-1 downregulation
In this study, we aimed to explore the transcriptome profiles of splenocytes deficient in fucosyltransferase (FUT) 1, an enzyme that mediates fucosylation, and investigate their impact on the proliferation and differentiation of T cells. We analysed and compared the transcriptomes of splenocytes isolated from Fut1 knockout (KO) mice and those from wild-type (WT) mice using RNA-seq. Additionally, we examined the effects of Fut1 KO splenocytes on CD4 T cell proliferation and differentiation, in comparison to WT splenocytes, and elucidated the mechanisms involved. The comparative analysis of transcriptomes between Fut1 KO and...
Source: Immunology - November 14, 2023 Category: Allergy & Immunology Authors: Jung Hwa Ko Jin Suk Ryu Jang-Hee Oh Joo Youn Oh Source Type: research
Intratracheal administration of cross-linked water-soluble acrylic acid polymer is associated with inducible bronchi-related lymphoid tissue formation and allergic inflammation
In this study, we investigated the effects of multiple intratracheal administrations of CWAAP on inflammatory responses and pulmonary fibrosis along with inducible bronchus-associated lymphoid tissues (iBALT) formation, which is involved in allergic inflammation. Male F344 rats (190-200 g) received single or multiple intratracheal administrations of phosphate-buffered saline (PBS) or CWAAP. To assess inflammatory responses and pulmonary fibrosis, immunohistochemical and histological staining was performed. CD68, CD163, CD169, TGF-β, and collagen I positive cells/areas in the lungs of the CWAAP-group rats were significantl...
Source: Immunology - November 14, 2023 Category: Allergy & Immunology Authors: Takamasa Kido Chiemi Sugaya Hiroshi Hano Hiroyuki Yanagisawa Machi Suka Source Type: research
Intestinal permeability and inflammatory features of juvenile age correlate with the eventual systemic autoimmunity in lupus-prone female SWR × NZB F1 (SNF1) mice
Immunology. 2023 Nov 10. doi: 10.1111/imm.13713. Online ahead of print.ABSTRACTThe incidence of systemic lupus erythematosus (SLE) is about nine times higher in women than in men, and the underlying mechanisms that contribute to this gender bias are not fully understood. Previously, using lupus-prone (SWR × NZB)F1 (SNF1) mice, we have shown that the intestinal immune system could play a role in the initiation and progression of disease in SLE, and depletion of gut microbiota produces more pronounced disease protection in females than in males. Here, we show that the gut permeability features of lupus-prone female SNF1 mic...
Source: Immunology - November 10, 2023 Category: Allergy & Immunology Authors: Radhika R Gudi Benjamin M Johnson Marie-Claude Gaudreau Wei Sun Lauren Ball Chenthamarakshan Vasu Source Type: research
Intestinal permeability and inflammatory features of juvenile age correlate with the eventual systemic autoimmunity in lupus-prone female SWR × NZB F1 (SNF1) mice
Immunology. 2023 Nov 10. doi: 10.1111/imm.13713. Online ahead of print.ABSTRACTThe incidence of systemic lupus erythematosus (SLE) is about nine times higher in women than in men, and the underlying mechanisms that contribute to this gender bias are not fully understood. Previously, using lupus-prone (SWR × NZB)F1 (SNF1) mice, we have shown that the intestinal immune system could play a role in the initiation and progression of disease in SLE, and depletion of gut microbiota produces more pronounced disease protection in females than in males. Here, we show that the gut permeability features of lupus-prone female SNF1 mic...
Source: Immunology - November 10, 2023 Category: Allergy & Immunology Authors: Radhika R Gudi Benjamin M Johnson Marie-Claude Gaudreau Wei Sun Lauren Ball Chenthamarakshan Vasu Source Type: research
Intestinal permeability and inflammatory features of juvenile age correlate with the eventual systemic autoimmunity in lupus-prone female SWR × NZB F1 (SNF1) mice
Immunology. 2023 Nov 10. doi: 10.1111/imm.13713. Online ahead of print.ABSTRACTThe incidence of systemic lupus erythematosus (SLE) is about nine times higher in women than in men, and the underlying mechanisms that contribute to this gender bias are not fully understood. Previously, using lupus-prone (SWR × NZB)F1 (SNF1) mice, we have shown that the intestinal immune system could play a role in the initiation and progression of disease in SLE, and depletion of gut microbiota produces more pronounced disease protection in females than in males. Here, we show that the gut permeability features of lupus-prone female SNF1 mic...
Source: Immunology - November 10, 2023 Category: Allergy & Immunology Authors: Radhika R Gudi Benjamin M Johnson Marie-Claude Gaudreau Wei Sun Lauren Ball Chenthamarakshan Vasu Source Type: research
