Psychological stress to ovalbumin peptide-specific T-cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell
In conclusion, the functions of Tr1 cells are negatively impacted by simultaneous exposure to psychological stress and immune response. Tr1 cells' immune suppressive functions can be restored by inhibiting Rnf20, which has the translational potential for the treatment of diseases of the immune system.PMID:38366844 | DOI:10.1111/imm.13767 (Source: Immunology)
Source: Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Xiaoyu Liu Xuejie Xu Yun Liao Wenkai Yao Xiaorui Geng Xianhai Zeng Xizhuo Sun Aifa Tang Pingchang Yang Source Type: research
Psychological stress to ovalbumin peptide-specific T-cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell
In conclusion, the functions of Tr1 cells are negatively impacted by simultaneous exposure to psychological stress and immune response. Tr1 cells' immune suppressive functions can be restored by inhibiting Rnf20, which has the translational potential for the treatment of diseases of the immune system.PMID:38366844 | DOI:10.1111/imm.13767 (Source: Immunology)
Source: Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Xiaoyu Liu Xuejie Xu Yun Liao Wenkai Yao Xiaorui Geng Xianhai Zeng Xizhuo Sun Aifa Tang Pingchang Yang Source Type: research
Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment
Immunology. 2024 Feb 15. doi: 10.1111/imm.13766. Online ahead of print.ABSTRACTMacrophages expressing group V phospholipase A2 (Pla2g5) release the free fatty acid (FFA) linoleic acid (LA), potentiating lung type 2 inflammation. Although Pla2g5 and LA increase in viral infections, their role remains obscure. We generated Pla2g5flox/flox mice, deleted Pla2g5 by using the Cx3cr1cre transgene, and activated bone marrow-derived macrophages (BM-Macs) with poly:IC, a synthetic double-stranded RNA that triggers a viral-like immune response, known Pla2g5-dependent stimuli (IL-4, LPS + IFNγ, IL-33 + IL-4 + GM-CSF) and poly:IC + LA...
Source: Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Masaya Koganesawa Daniel F Dwyer Kinan Alhallak Jun Nagai Kendall Zaleski Sachin Samuchiwal Hayashi Hiroaki Airi Nishida Thomas I Hirsch Patrick J Brennan Mark Puder Barbara Balestrieri Source Type: research
NK92 cells and peripheral blood NK cells respond oppositely upon dasatinib treatment
Immunology. 2024 Feb 15. doi: 10.1111/imm.13768. Online ahead of print.ABSTRACTNatural killer (NK) cell is a valuable tool for immunotherapy in cancer treatment, both the cultured cell line NK92 and primary NK cells are widely studied and used in research and clinical trials. Clinical observations witnessed the improvement of patients' NK cells in terms of cell counts and cytotoxic activity upon dasatinib treatment, an approved drug for chronic myeloid leukaemia and Ph+ acute lymphocytic leukaemia. Several studies supported the clinical observations, yet others argued a detrimental effect of dasatinib on NK cells. Due to t...
Source: Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Fengqi Li Zhongyi Wang Dongpeng Zheng Zhaojun Pang Chunjing Feng Yue Ma Ce Yang Xueren Li Shouchun Peng Zichuan Liu Xin Mu Source Type: research
Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment
Immunology. 2024 Feb 15. doi: 10.1111/imm.13766. Online ahead of print.ABSTRACTMacrophages expressing group V phospholipase A2 (Pla2g5) release the free fatty acid (FFA) linoleic acid (LA), potentiating lung type 2 inflammation. Although Pla2g5 and LA increase in viral infections, their role remains obscure. We generated Pla2g5flox/flox mice, deleted Pla2g5 by using the Cx3cr1cre transgene, and activated bone marrow-derived macrophages (BM-Macs) with poly:IC, a synthetic double-stranded RNA that triggers a viral-like immune response, known Pla2g5-dependent stimuli (IL-4, LPS + IFNγ, IL-33 + IL-4 + GM-CSF) and poly:IC + LA...
Source: Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Masaya Koganesawa Daniel F Dwyer Kinan Alhallak Jun Nagai Kendall Zaleski Sachin Samuchiwal Hayashi Hiroaki Airi Nishida Thomas I Hirsch Patrick J Brennan Mark Puder Barbara Balestrieri Source Type: research
NK92 cells and peripheral blood NK cells respond oppositely upon dasatinib treatment
Immunology. 2024 Feb 15. doi: 10.1111/imm.13768. Online ahead of print.ABSTRACTNatural killer (NK) cell is a valuable tool for immunotherapy in cancer treatment, both the cultured cell line NK92 and primary NK cells are widely studied and used in research and clinical trials. Clinical observations witnessed the improvement of patients' NK cells in terms of cell counts and cytotoxic activity upon dasatinib treatment, an approved drug for chronic myeloid leukaemia and Ph+ acute lymphocytic leukaemia. Several studies supported the clinical observations, yet others argued a detrimental effect of dasatinib on NK cells. Due to t...
Source: Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Fengqi Li Zhongyi Wang Dongpeng Zheng Zhaojun Pang Chunjing Feng Yue Ma Ce Yang Xueren Li Shouchun Peng Zichuan Liu Xin Mu Source Type: research
Role of airway epithelium in viral respiratory infections: Can carbocysteine prevent or mitigate them?
Immunology. 2024 Feb 14. doi: 10.1111/imm.13762. Online ahead of print.ABSTRACTAlterations in airway epithelial homeostasis increase viral respiratory infections risk. Viral infections frequently are associated with chronic obstructive pulmonary disease (COPD) exacerbations, events that dramatically promote disease progression. Mechanism promoting the main respiratory viruses entry and virus-evocated innate and adaptive immune responses have now been elucidated, and an oxidative stress central role in these pathogenic processes has been recognized. Presence of reactive oxygen species in macrophages and other cells allows t...
Source: Immunology - February 14, 2024 Category: Allergy & Immunology Authors: Elisabetta Pace Serena Di Vincenzo Maria Ferraro Luigi Lanata Francesco Scaglione Source Type: research
Myeloid-derived suppressor cells from tumour-bearing mice induce the population expansion of CD19 < sup > hi < /sup > Fc γRIIb < sup > hi < /sup > regulatory B cells via PD-L1
Immunology. 2024 Feb 8. doi: 10.1111/imm.13763. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSCs) increase in number and gain immunosuppressive functions in tumours and many other pathological conditions. MDSCs are characterized by their strong T-cell immunosuppressive capacity. The effects that MDSCs may have on B cells, especially within the tumour microenvironment, are less well understood. Here, we report that either monocytic MDSCs or polymorphonuclear MDSCs can promote increases in interleukin (IL)-10-expressing CD19hi FcγRIIbhi regulatory B cells in vitro and in vivo. Splenic transitional-1, -2...
Source: Immunology - February 9, 2024 Category: Allergy & Immunology Authors: Wenyan Chen Xiaomin Ning Yang Liu Tingting Shen Mengru Liu Hui Yin Yue Ding Jingwen Zhou Rui Yin Liangliang Cai Yuhan Wu Li Qian Source Type: research
Immunopathology in human pulmonary tuberculosis: Inflammatory changes in the plasma milieu and impaired host immune cell functions
Immunology. 2024 Feb 5. doi: 10.1111/imm.13761. Online ahead of print.ABSTRACTHost immune response is key for protection in tuberculosis, but the causative agent, Mycobacterium (M.) tuberculosis, manages to survive despite immune surveillance. Key mechanisms of immune protection have been identified, but the role of immunopathology in the peripheral blood of tuberculosis patients remains unclear. Tuberculosis immunopathology in the blood is characterised by patterns of immunosuppression and hyperinflammation. These seemingly contradictory findings and the pronounced heterogeneity made it difficult to interpret the results ...
Source: Immunology - February 6, 2024 Category: Allergy & Immunology Authors: Hubert Senanu Ahor Monika Vivekanandan Jean De Dieu Harelimana Dorcas O Owusu Ernest Adankwah Julia Seyfarth Richard Phillips Marc Jacobsen Source Type: research
Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation
Immunology. 2024 Feb 5. doi: 10.1111/imm.13758. Online ahead of print.ABSTRACTDendritic cells (DCs) are the most significant antigen presenting cells of the immune system, critical for the activation of naïve T cells. The pathways controlling DC development, maturation, and effector function therefore require precise regulation to allow for an effective induction of adaptive immune response. MYSM1 is a chromatin binding deubiquitinase (DUB) and an activator of gene expression via its catalytic activity for monoubiquitinated histone H2A (H2A-K119ub), which is a highly abundant repressive epigenetic mark. MYSM1 is an import...
Source: Immunology - February 5, 2024 Category: Allergy & Immunology Authors: Marwah Mousa Yue Liang Lin Tze Tung HanChen Wang Connie Krawczyk David Langlais Anastasia Nijnik Source Type: research
Abrogation and homeostatic restoration of IgE responses by a universal IgE allergy CTL vaccine-The three signal self/non-self/self (S/NS/S) theory
Immunology. 2024 Feb 1. doi: 10.1111/imm.13753. Online ahead of print.ABSTRACTNatural IgE cytotoxic peptides (nECPs), which are derived from the constant domain of the heavy chain of human IgE producing B cells via endoplasmic reticulum (ER) stress, are decorated onto MHC class 1a molecules (MHCIa) as unique biomarkers for CTL (cytotoxic T lymphocyte)-mediated immune surveillance. Human IgE exhibits only one isotype and lacks polymorphisms; IgE is pivotal in mediating diverse, allergen-specific allergies. Therefore, by disrupting self-IgE tolerance via costimulation, the CTLs induced by nECPs can serve as universal allergy...
Source: Immunology - February 2, 2024 Category: Allergy & Immunology Authors: Swey-Shen Chen Hailan Zhang Source Type: research
The correlation between systemic inflammatory markers and efficiency for advanced gastric cancer patients treated with ICIs combined with chemotherapy
This study is a retrospective study and included patients with advanced gastric cancer who receiving ICIs combined with chemotherapy from January 2020 to December 2022. We analysed the relationship between systemic inflammatory markers and the efficacy of ICIs combined chemotherapy and constructed a clinical prediction model. A nomogram was constructed based on the results of the bidirectional stepwise regression model. A total of 197 patients were enrolled in the training group, with a median follow-up period of time 26 months. Kaplan Meier analysis showed that the median OS of patients with low systemic immune-inflammato...
Source: Immunology - January 25, 2024 Category: Allergy & Immunology Authors: Qiuxia Dong Fuxing Zhao Yuying Li Feixue Song Enxi Li Lihong Gao Yuanfang Xin Guoshuang Shen Dengfeng Ren Miaozhou Wang Yi Zhao Zhen Liu Qiqi Xie Zhilin Liu Zitao Li Jiuda Zhao Source Type: research
PD-1: A critical player and target for immune normalization
Immunology. 2024 Jan 25. doi: 10.1111/imm.13755. Online ahead of print.ABSTRACTImmune system imbalances contribute to the pathogenesis of several different diseases, and immunotherapy shows great therapeutic efficacy against tumours and infectious diseases with immune-mediated derivations. In recent years, molecules targeting the programmed cell death protein 1 (PD-1) immune checkpoint have attracted much attention, and related signalling pathways have been studied clearly. At present, several inhibitors and antibodies targeting PD-1 have been utilized as anti-tumour therapies. However, increasing evidence indicates that P...
Source: Immunology - January 25, 2024 Category: Allergy & Immunology Authors: Xuening Liu Alison Zhao Su Xiao Haohao Li Menghua Li Wei Guo Qiuju Han Source Type: research
The Neurobeachin-like 2 protein (NBEAL2) controls the homeostatic level of the ribosomal protein RPS6 in mast cells
Immunology. 2024 Jan 25. doi: 10.1111/imm.13756. Online ahead of print.ABSTRACTThe Beige and Chediak-Higashi (BEACH) domain-containing, Neurobeachin-like 2 (NBEAL2) protein is a molecule with a molecular weight of 300 kDa. Inactivation of NBEAL2 by loss-of-function mutations in humans as well as deletion of the Nbeal2 gene in mice results in functional defects in cells of the innate immune system such as neutrophils, NK-cells, megakaryocytes, platelets and of mast cells (MCs). To investigate the detailed function of NBEAL2 in murine MCs we generated MCs from wild type (wt) and Nbeal2-/- mice, and deleted Nbeal2 by CRISPR/C...
Source: Immunology - January 25, 2024 Category: Allergy & Immunology Authors: Philine Wegner Julia Drube Lisa Ziegler Birgit Strotmann Raphaela Marquardt Claudia K üchler Marco Groth Bernhard Nieswandt Nico Andreas Sebastian Drube Source Type: research
Chimerism of avian IgY-scFv and truncated IgG-Fc: A novel strategy in cross-species antibody generation and enhancement
In this study, engineered mammalian ΔFc domains (CH2, CH3, and intact Fc region) were fused with anti-canine parvovirus-like particles avian IgY-scFv to produce chimeric antibodies and expressed in the HEK293 cell expression system. The obtained scFv-CH2, scFv-CH3, and scFv-Fc can bind with antigen specifically and dose-dependently. Surface plasmon resonance investigation confirmed that scFv-CH2, scFv-CH3, and scFv-Fc had different degrees of binding to FcRn, with scFv-Fc showing the highest affinity. scFv-Fc had a significantly longer half-life in mice compared with the unfused scFv. The identified ΔFcs are promising fo...
Source: Immunology - January 22, 2024 Category: Allergy & Immunology Authors: Shikun Ge Alberto Carlos Pires Dias Xiaoying Zhang Source Type: research
