Celiprolol and sympatho-immune interface in COVID-19
Immunology. 2023 Sep 7. doi: 10.1111/imm.13693. Online ahead of print.NO ABSTRACTPMID:37679864 | DOI:10.1111/imm.13693 (Source: Immunology)
Source: Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Hayder M Al-Kuraishy Ali K Albuhadily Ali I Al-Gareeb Maisra M El-Bouseary Athanasios Alexiou Marios Papadakis Gaber El-Saber Batiha Source Type: research
Celiprolol and sympatho-immune interface in COVID-19
Immunology. 2023 Sep 7. doi: 10.1111/imm.13693. Online ahead of print.NO ABSTRACTPMID:37679864 | DOI:10.1111/imm.13693 (Source: Immunology)
Source: Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Hayder M Al-Kuraishy Ali K Albuhadily Ali I Al-Gareeb Maisra M El-Bouseary Athanasios Alexiou Marios Papadakis Gaber El-Saber Batiha Source Type: research
Interleukin-7 improves the fitness of regulatory T cells for adoptive transfer
In conclusion, our data demonstrate the feasibility of expanding naïve Treg in the presence of IL-7 to generate a Treg product enriched in poorly differentiated CD45RA+ cells with enhanced survival capabilities.PMID:37671510 | DOI:10.1111/imm.13690 (Source: Immunology)
Source: Immunology - September 6, 2023 Category: Allergy & Immunology Authors: Ilaria Cosorich Jessica Filoni Carla Di Dedda Arianna Ferrari Tatiana Jofra Susanna Cesarano Chiara Bonini Lorenzo Piemonti Paolo Monti Source Type: research
Interleukin-7 improves the fitness of regulatory T cells for adoptive transfer
In conclusion, our data demonstrate the feasibility of expanding naïve Treg in the presence of IL-7 to generate a Treg product enriched in poorly differentiated CD45RA+ cells with enhanced survival capabilities.PMID:37671510 | DOI:10.1111/imm.13690 (Source: Immunology)
Source: Immunology - September 6, 2023 Category: Allergy & Immunology Authors: Ilaria Cosorich Jessica Filoni Carla Di Dedda Arianna Ferrari Tatiana Jofra Susanna Cesarano Chiara Bonini Lorenzo Piemonti Paolo Monti Source Type: research
Immunometabolism in the pathogenesis of asthma
Immunology. 2023 Aug 31. doi: 10.1111/imm.13688. Online ahead of print.ABSTRACTBronchial asthma is a heterogeneous disease characterised by chronic airway inflammation. A variety of immune cells such as eosinophils, mast cells, T lymphocytes, neutrophils and airway epithelial cells are involved in the airway inflammation and airway hyperresponsiveness in asthma pathogenesis, resulting in extensive and variable reversible expiratory airflow limitation. However, the precise molecular mechanisms underlying the allergic immune responses, particularly immunometabolism, remains unclear. Studies have detected enhanced oxidative s...
Source: Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Ziwen Qin Yujuan Chen Yue Wang Yeyang Xu Tingting Liu Qian Mu Chuanjun Huang Source Type: research
Immunometabolism in the pathogenesis of asthma
Immunology. 2023 Aug 31. doi: 10.1111/imm.13688. Online ahead of print.ABSTRACTBronchial asthma is a heterogeneous disease characterised by chronic airway inflammation. A variety of immune cells such as eosinophils, mast cells, T lymphocytes, neutrophils and airway epithelial cells are involved in the airway inflammation and airway hyperresponsiveness in asthma pathogenesis, resulting in extensive and variable reversible expiratory airflow limitation. However, the precise molecular mechanisms underlying the allergic immune responses, particularly immunometabolism, remains unclear. Studies have detected enhanced oxidative s...
Source: Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Ziwen Qin Yujuan Chen Yue Wang Yeyang Xu Tingting Liu Qian Mu Chuanjun Huang Source Type: research
Immunometabolism in the pathogenesis of asthma
Immunology. 2023 Aug 31. doi: 10.1111/imm.13688. Online ahead of print.ABSTRACTBronchial asthma is a heterogeneous disease characterised by chronic airway inflammation. A variety of immune cells such as eosinophils, mast cells, T lymphocytes, neutrophils and airway epithelial cells are involved in the airway inflammation and airway hyperresponsiveness in asthma pathogenesis, resulting in extensive and variable reversible expiratory airflow limitation. However, the precise molecular mechanisms underlying the allergic immune responses, particularly immunometabolism, remains unclear. Studies have detected enhanced oxidative s...
Source: Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Ziwen Qin Yujuan Chen Yue Wang Yeyang Xu Tingting Liu Qian Mu Chuanjun Huang Source Type: research
Immunometabolism in the pathogenesis of asthma
Immunology. 2023 Aug 31. doi: 10.1111/imm.13688. Online ahead of print.ABSTRACTBronchial asthma is a heterogeneous disease characterised by chronic airway inflammation. A variety of immune cells such as eosinophils, mast cells, T lymphocytes, neutrophils and airway epithelial cells are involved in the airway inflammation and airway hyperresponsiveness in asthma pathogenesis, resulting in extensive and variable reversible expiratory airflow limitation. However, the precise molecular mechanisms underlying the allergic immune responses, particularly immunometabolism, remains unclear. Studies have detected enhanced oxidative s...
Source: Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Ziwen Qin Yujuan Chen Yue Wang Yeyang Xu Tingting Liu Qian Mu Chuanjun Huang Source Type: research
Immunometabolism in the pathogenesis of asthma
Immunology. 2023 Aug 31. doi: 10.1111/imm.13688. Online ahead of print.ABSTRACTBronchial asthma is a heterogeneous disease characterised by chronic airway inflammation. A variety of immune cells such as eosinophils, mast cells, T lymphocytes, neutrophils and airway epithelial cells are involved in the airway inflammation and airway hyperresponsiveness in asthma pathogenesis, resulting in extensive and variable reversible expiratory airflow limitation. However, the precise molecular mechanisms underlying the allergic immune responses, particularly immunometabolism, remains unclear. Studies have detected enhanced oxidative s...
Source: Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Ziwen Qin Yujuan Chen Yue Wang Yeyang Xu Tingting Liu Qian Mu Chuanjun Huang Source Type: research
Ceftazidime reduces cellular Skp2 to promote type-I interferon activity
This study reveals a new role of Skp2 in regulating IFN-I signalling and IFN-I antiviral activity and reports the antibiotic ceftazidime as a potential repressor of Skp2.PMID:37641430 | DOI:10.1111/imm.13687 (Source: Immunology)
Source: Immunology - August 29, 2023 Category: Allergy & Immunology Authors: Caixia Qiao Fan Huang Jiuyi He Qiuyu Wu Zhijin Zheng Tingting Zhang Ying Miao Yukang Yuan Xiangjie Chen Qian Du Yang Xu Depei Wu Zhengyuan Yu Hui Zheng Source Type: research
Ceftazidime reduces cellular Skp2 to promote type-I interferon activity
This study reveals a new role of Skp2 in regulating IFN-I signalling and IFN-I antiviral activity and reports the antibiotic ceftazidime as a potential repressor of Skp2.PMID:37641430 | DOI:10.1111/imm.13687 (Source: Immunology)
Source: Immunology - August 29, 2023 Category: Allergy & Immunology Authors: Caixia Qiao Fan Huang Jiuyi He Qiuyu Wu Zhijin Zheng Tingting Zhang Ying Miao Yukang Yuan Xiangjie Chen Qian Du Yang Xu Depei Wu Zhengyuan Yu Hui Zheng Source Type: research
Ceftazidime reduces cellular Skp2 to promote type-I interferon activity
This study reveals a new role of Skp2 in regulating IFN-I signalling and IFN-I antiviral activity and reports the antibiotic ceftazidime as a potential repressor of Skp2.PMID:37641430 | DOI:10.1111/imm.13687 (Source: Immunology)
Source: Immunology - August 29, 2023 Category: Allergy & Immunology Authors: Caixia Qiao Fan Huang Jiuyi He Qiuyu Wu Zhijin Zheng Tingting Zhang Ying Miao Yukang Yuan Xiangjie Chen Qian Du Yang Xu Depei Wu Zhengyuan Yu Hui Zheng Source Type: research
Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis
Immunology. 2023 Aug 27. doi: 10.1111/imm.13686. Online ahead of print.ABSTRACTUnder perturbing conditions such as infection with Leishmania, a protozoan parasite living within the phagosomes in mammalian macrophages, cellular and organellar structures, and metabolism are dynamically regulated for neutralizing the pressure of parasitism. However, how modulations of the host cell metabolic pathways support Leishmania infection remains unknown. Herein, we report that lipid accumulation heightens the susceptibility of mice to L. donovani infection and promotes resistance to first-line anti-leishmanial drugs. Despite being pro...
Source: Immunology - August 28, 2023 Category: Allergy & Immunology Authors: Marta Ara újo Diana Moreira In ês Mesquita Carolina Ferreira Ana Mendes-Frias S ónia Barros-Carvalho Ricardo Jorge Dinis-Oliveira Cl áudio Duarte-Oliveira Cristina Cunha Agostinho Carvalho Bhaskar Saha Anabela Cordeiro-da-Silva J érôme Estaquier Ric Source Type: research
Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis
Immunology. 2023 Aug 27. doi: 10.1111/imm.13686. Online ahead of print.ABSTRACTUnder perturbing conditions such as infection with Leishmania, a protozoan parasite living within the phagosomes in mammalian macrophages, cellular and organellar structures, and metabolism are dynamically regulated for neutralizing the pressure of parasitism. However, how modulations of the host cell metabolic pathways support Leishmania infection remains unknown. Herein, we report that lipid accumulation heightens the susceptibility of mice to L. donovani infection and promotes resistance to first-line anti-leishmanial drugs. Despite being pro...
Source: Immunology - August 28, 2023 Category: Allergy & Immunology Authors: Marta Ara újo Diana Moreira In ês Mesquita Carolina Ferreira Ana Mendes-Frias S ónia Barros-Carvalho Ricardo Jorge Dinis-Oliveira Cl áudio Duarte-Oliveira Cristina Cunha Agostinho Carvalho Bhaskar Saha Anabela Cordeiro-da-Silva J érôme Estaquier Ric Source Type: research
A robust platform for integrative spatial multi-omics analysis to map immune responses to SARS-CoV-2 infection in lung tissues
Immunology. 2023 Aug 21. doi: 10.1111/imm.13679. Online ahead of print.ABSTRACTThe SARS-CoV-2 (COVID-19) virus has caused a devastating global pandemic of respiratory illness. To understand viral pathogenesis, methods are available for studying dissociated cells in blood, nasal samples, bronchoalveolar lavage fluid and similar, but a robust platform for deep tissue characterization of molecular and cellular responses to virus infection in the lungs is still lacking. We developed an innovative spatial multi-omics platform to investigate COVID-19-infected lung tissues. Five tissue-profiling technologies were combined by a no...
Source: Immunology - August 22, 2023 Category: Allergy & Immunology Authors: Xiao Tan Laura F Grice Minh Tran Onkar Mulay James Monkman Tony Blick Tuan Vo Ana Clara Almeida Jarbas da Silva Motta Karen Fernandes de Moura Cleber Machado-Souza Paulo Souza-Fonseca-Guimaraes Cristina Pellegrino Baena Lucia de Noronha Fernanda Simoes Fo Source Type: research
