PD-1 expression on tumour-infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B-cell lymphoma
CONCLUSION: We determined the clinical impact of microenvironmental PD-1 expression and its relationship with neoplastic or microenvironmental expression of PD-L1 in patients with R/R DLBCL. The expression of PD-1 and PD-L1 in the TME dramatically changes during the chemotherapy. Therefore, evaluating TME at relapse, not at diagnosis is useful to predict the outcomes of R/R DLBCL patients.PMID:37904615 | DOI:10.1111/imm.13711 (Source: Immunology)
Source: Immunology - October 31, 2023 Category: Allergy & Immunology Authors: Fumiya Wada Kimimori Kamijo Yoshimitsu Shimomura Daisuke Yamashita Shigeo Hara Takayuki Ishikawa Source Type: research
PD-1 expression on tumour-infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B-cell lymphoma
CONCLUSION: We determined the clinical impact of microenvironmental PD-1 expression and its relationship with neoplastic or microenvironmental expression of PD-L1 in patients with R/R DLBCL. The expression of PD-1 and PD-L1 in the TME dramatically changes during the chemotherapy. Therefore, evaluating TME at relapse, not at diagnosis is useful to predict the outcomes of R/R DLBCL patients.PMID:37904615 | DOI:10.1111/imm.13711 (Source: Immunology)
Source: Immunology - October 31, 2023 Category: Allergy & Immunology Authors: Fumiya Wada Kimimori Kamijo Yoshimitsu Shimomura Daisuke Yamashita Shigeo Hara Takayuki Ishikawa Source Type: research
PD-1 expression on tumour-infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B-cell lymphoma
CONCLUSION: We determined the clinical impact of microenvironmental PD-1 expression and its relationship with neoplastic or microenvironmental expression of PD-L1 in patients with R/R DLBCL. The expression of PD-1 and PD-L1 in the TME dramatically changes during the chemotherapy. Therefore, evaluating TME at relapse, not at diagnosis is useful to predict the outcomes of R/R DLBCL patients.PMID:37904615 | DOI:10.1111/imm.13711 (Source: Immunology)
Source: Immunology - October 31, 2023 Category: Allergy & Immunology Authors: Fumiya Wada Kimimori Kamijo Yoshimitsu Shimomura Daisuke Yamashita Shigeo Hara Takayuki Ishikawa Source Type: research
PD-1 expression on tumour-infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B-cell lymphoma
CONCLUSION: We determined the clinical impact of microenvironmental PD-1 expression and its relationship with neoplastic or microenvironmental expression of PD-L1 in patients with R/R DLBCL. The expression of PD-1 and PD-L1 in the TME dramatically changes during the chemotherapy. Therefore, evaluating TME at relapse, not at diagnosis is useful to predict the outcomes of R/R DLBCL patients.PMID:37904615 | DOI:10.1111/imm.13711 (Source: Immunology)
Source: Immunology - October 31, 2023 Category: Allergy & Immunology Authors: Fumiya Wada Kimimori Kamijo Yoshimitsu Shimomura Daisuke Yamashita Shigeo Hara Takayuki Ishikawa Source Type: research
PD-1 expression on tumour-infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B-cell lymphoma
CONCLUSION: We determined the clinical impact of microenvironmental PD-1 expression and its relationship with neoplastic or microenvironmental expression of PD-L1 in patients with R/R DLBCL. The expression of PD-1 and PD-L1 in the TME dramatically changes during the chemotherapy. Therefore, evaluating TME at relapse, not at diagnosis is useful to predict the outcomes of R/R DLBCL patients.PMID:37904615 | DOI:10.1111/imm.13711 (Source: Immunology)
Source: Immunology - October 31, 2023 Category: Allergy & Immunology Authors: Fumiya Wada Kimimori Kamijo Yoshimitsu Shimomura Daisuke Yamashita Shigeo Hara Takayuki Ishikawa Source Type: research
PD-1 expression on tumour-infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B-cell lymphoma
CONCLUSION: We determined the clinical impact of microenvironmental PD-1 expression and its relationship with neoplastic or microenvironmental expression of PD-L1 in patients with R/R DLBCL. The expression of PD-1 and PD-L1 in the TME dramatically changes during the chemotherapy. Therefore, evaluating TME at relapse, not at diagnosis is useful to predict the outcomes of R/R DLBCL patients.PMID:37904615 | DOI:10.1111/imm.13711 (Source: Immunology)
Source: Immunology - October 31, 2023 Category: Allergy & Immunology Authors: Fumiya Wada Kimimori Kamijo Yoshimitsu Shimomura Daisuke Yamashita Shigeo Hara Takayuki Ishikawa Source Type: research
PD-1 expression on tumour-infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B-cell lymphoma
CONCLUSION: We determined the clinical impact of microenvironmental PD-1 expression and its relationship with neoplastic or microenvironmental expression of PD-L1 in patients with R/R DLBCL. The expression of PD-1 and PD-L1 in the TME dramatically changes during the chemotherapy. Therefore, evaluating TME at relapse, not at diagnosis is useful to predict the outcomes of R/R DLBCL patients.PMID:37904615 | DOI:10.1111/imm.13711 (Source: Immunology)
Source: Immunology - October 31, 2023 Category: Allergy & Immunology Authors: Fumiya Wada Kimimori Kamijo Yoshimitsu Shimomura Daisuke Yamashita Shigeo Hara Takayuki Ishikawa Source Type: research
PD-1 expression on tumour-infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B-cell lymphoma
CONCLUSION: We determined the clinical impact of microenvironmental PD-1 expression and its relationship with neoplastic or microenvironmental expression of PD-L1 in patients with R/R DLBCL. The expression of PD-1 and PD-L1 in the TME dramatically changes during the chemotherapy. Therefore, evaluating TME at relapse, not at diagnosis is useful to predict the outcomes of R/R DLBCL patients.PMID:37904615 | DOI:10.1111/imm.13711 (Source: Immunology)
Source: Immunology - October 31, 2023 Category: Allergy & Immunology Authors: Fumiya Wada Kimimori Kamijo Yoshimitsu Shimomura Daisuke Yamashita Shigeo Hara Takayuki Ishikawa Source Type: research
PD-1 expression on tumour-infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B-cell lymphoma
CONCLUSION: We determined the clinical impact of microenvironmental PD-1 expression and its relationship with neoplastic or microenvironmental expression of PD-L1 in patients with R/R DLBCL. The expression of PD-1 and PD-L1 in the TME dramatically changes during the chemotherapy. Therefore, evaluating TME at relapse, not at diagnosis is useful to predict the outcomes of R/R DLBCL patients.PMID:37904615 | DOI:10.1111/imm.13711 (Source: Immunology)
Source: Immunology - October 31, 2023 Category: Allergy & Immunology Authors: Fumiya Wada Kimimori Kamijo Yoshimitsu Shimomura Daisuke Yamashita Shigeo Hara Takayuki Ishikawa Source Type: research
Embedding of exogenous B cell epitopes on the surface of UreB structure generates a broadly reactive antibody response against Helicobacter pylori
This study not only provides promising immunotherapy to control H. pylori infection but also offers a reference for antigen engineering against other pathogens.PMID:37899627 | DOI:10.1111/imm.13703 (Source: Immunology)
Source: Immunology - October 30, 2023 Category: Allergy & Immunology Authors: Qianyu Ji Junfei Ma Shuying Wang Qing Liu Source Type: research
Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2
We report the interaction of TLR4, MD2 and the TLR4-MD2 complex with heme and the consequences thereof by employing biochemical, spectroscopic, bioinformatic and physiologically relevant approaches. Heme binding occurs transiently through interaction with up to four HBMs in TLR4, two HBMs in MD2 and at least four HBMs in their complex. Functional studies highlight that mutations of individual HBMs in TLR4 preserve full receptor activation by heme, suggesting that heme interacts with TLR4 through different binding sites independently of MD2. Furthermore, we confirm and extend the major role of TLR4 for heme-mediated cytokin...
Source: Immunology - October 27, 2023 Category: Allergy & Immunology Authors: Marie-T Hopp Janine Holze Felicitas Lauber Laura Holtkamp Dhruv C Rathod Maria A Miteva Elisa B Prestes Matthias Geyer B énédicte Manoury Nicolas S Merle Lubka T Roumenina Marcelo T Bozza G ünther Weindl Diana Imhof Source Type: research
Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2
We report the interaction of TLR4, MD2 and the TLR4-MD2 complex with heme and the consequences thereof by employing biochemical, spectroscopic, bioinformatic and physiologically relevant approaches. Heme binding occurs transiently through interaction with up to four HBMs in TLR4, two HBMs in MD2 and at least four HBMs in their complex. Functional studies highlight that mutations of individual HBMs in TLR4 preserve full receptor activation by heme, suggesting that heme interacts with TLR4 through different binding sites independently of MD2. Furthermore, we confirm and extend the major role of TLR4 for heme-mediated cytokin...
Source: Immunology - October 27, 2023 Category: Allergy & Immunology Authors: Marie-T Hopp Janine Holze Felicitas Lauber Laura Holtkamp Dhruv C Rathod Maria A Miteva Elisa B Prestes Matthias Geyer B énédicte Manoury Nicolas S Merle Lubka T Roumenina Marcelo T Bozza G ünther Weindl Diana Imhof Source Type: research
Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2
We report the interaction of TLR4, MD2 and the TLR4-MD2 complex with heme and the consequences thereof by employing biochemical, spectroscopic, bioinformatic and physiologically relevant approaches. Heme binding occurs transiently through interaction with up to four HBMs in TLR4, two HBMs in MD2 and at least four HBMs in their complex. Functional studies highlight that mutations of individual HBMs in TLR4 preserve full receptor activation by heme, suggesting that heme interacts with TLR4 through different binding sites independently of MD2. Furthermore, we confirm and extend the major role of TLR4 for heme-mediated cytokin...
Source: Immunology - October 27, 2023 Category: Allergy & Immunology Authors: Marie-T Hopp Janine Holze Felicitas Lauber Laura Holtkamp Dhruv C Rathod Maria A Miteva Elisa B Prestes Matthias Geyer B énédicte Manoury Nicolas S Merle Lubka T Roumenina Marcelo T Bozza G ünther Weindl Diana Imhof Source Type: research
CD57 T cells associated with immunosenescence in adults living with HIV or AIDS
Immunology. 2023 Oct 25. doi: 10.1111/imm.13707. Online ahead of print.ABSTRACTDespite the advancement of human immunodeficiency virus (HIV)-related discoveries, new HIV infections still persist. With the advent of antiretroviral therapy, prognosis has migrated from acute to chronic HIV infection and inflammation, with the possibility of increased immune aging. We aimed to assess such immunosenescence by analysing CD27 and CD57 expression on the surface of T cells. This cross-sectional study was conducted between 2017 and 2018 on people living with HIV/AIDS (PLWHA) who attended an outpatient clinic of the Infectious Diseas...
Source: Immunology - October 26, 2023 Category: Allergy & Immunology Authors: Erivaldo Elias Junior Vanessa T Gubert Camila M Bonin-Jacob Marco Antonio M Puga Cl áudia G Gouveia Angela H Sichinel In ês A Tozetti Source Type: research
CD8+CD103+PD1+TIM3+ T cells in glioblastoma microenvironment correlate with prognosis
This study aimed to determine whether the expression of selected immune checkpoints on tissue-resident memory T cells (Trm) may predict patient outcome. We conducted a single cohort observational study. Tumour samples were collected from 45 patients with histologically confirmed GB (WHO grade 4) and processed to obtain single-cell suspensions. Patients were assessed for the correlation of Trm phenotype with overall survival (OS) or progression-free survival (PFS) using multiparametric flow cytometry and uni/multivariate analyses. Levels of Trm expressing programmed cell death protein 1 (PD1) and T cell immunoglobulin and m...
Source: Immunology - October 26, 2023 Category: Allergy & Immunology Authors: Giulia Romagnoli Quintino Giorgio D'Alessandris Imerio Capone Andrea Tavilla Irene Canini Caterina Lapenta Mariachiara Buccarelli Martina Giordano Valentina Tirelli Massimo Sanchez Alessandra Fragale Stefano Giannetti Rina Di Bonaventura Liverana Lauretti Source Type: research
