Id1 expression in CD4 T cells promotes differentiation and function of follicular helper T cells and upregulation of related functional molecules
In conclusion, E proteins play a crucial role in regulating TFH/TFR cell differentiation and function and suppressing E protein activity promotes germinal centre humoral immunity, which has important implications for immune regulation and treating related diseases.PMID:38501859 | DOI:10.1111/imm.13782 (Source: Immunology)
Source: Immunology - March 19, 2024 Category: Allergy & Immunology Authors: Chen Liu Xingyue Zeng Ziqi Xiong Ayibaota Bahabayi Ainizati Hasimu Tianci Liu Mohan Zheng Liwei Ren Xiayidan Alimu Songsong Lu Source Type: research
Sialic acid in the regulation of blood cell production, differentiation and turnover
Immunology. 2024 Mar 19. doi: 10.1111/imm.13780. Online ahead of print.ABSTRACTSialic acid is a unique sugar moiety that resides in the distal and most accessible position of the glycans on mammalian cell surface and extracellular glycoproteins and glycolipids. The potential for sialic acid to obscure underlying structures has long been postulated, but the means by which such structural changes directly affect biological processes continues to be elucidated. Here, we appraise the growing body of literature detailing the importance of sialic acid for the generation, differentiation, function and death of haematopoietic cell...
Source: Immunology - March 19, 2024 Category: Allergy & Immunology Authors: Eric Edward Irons Sajina Gc Joseph T Y Lau Source Type: research
Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids
This study analysed in vitro pro-inflammatory activity of inflammatory cytokines (TNFα and IL-1β) in a combination with a lipid DAMP molecule, oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC). The study was performed on endothelial and monocytic cell lines. The cells were treated with different concentrations of TNFα or IL-1β, OxPAPC and their combinations, either in the presence or absence of drugs regulating inflammation. Pro-inflammatory effects of TNFα/IL-1β and OxPAPC were estimated by analysis of chemokines CXCL8, CXCL2 and CXCL3 by ELISA and RT-PCR. Toxicity was determined by analysis of metabolic ...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Alma Hodzic Bernd Gesslbauer Valery Bochkov Olga V Oskolkova Source Type: research
TREM1/DAP12 based novel multiple chain CAR-T cells targeting DLL3 show robust anti-tumour efficacy for small cell lung cancer
In this study, we have developed a DLL3-TREM1/DAP12 CAR-T (DLL3-DT CAR-T) therapy, demonstrating comparable anti-tumour efficacy against SCLC cells in vitro. In murine xenograft and patient-derived xenograft models, DLL3-DT CAR-T cells exhibited a more robust tumour eradication efficiency than second-generation DLL3-BBZ CAR-T cells. Furthermore, we observed elevated memory phenotypes, induced durable responses, and activation under antigen-presenting cells in DLL3-DT CAR-T cells. Collectively, these findings suggest that DLL3-DT CAR-T cells may offer a novel and potentially effective therapeutic strategy for treating DLL3-...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Fengqi Nie Yuli Chen Yanming Hu Peng Huang Xuefei Shi Jingsheng Cai Mantang Qiu Enxiu Wang Kaihua Lu Ming Sun Source Type: research
Prevention and treatment of HPV-related cancer through a mRNA vaccine expressing APC-targeting antigen
In conclusion, this study described a therapeutic mRNA vaccine inducing strong anti-tumour immunity in peripheral and in tumour microenvironment, holding promising potential to treat HPV-induced cancer and to prevent cancer recurrence.PMID:38471664 | DOI:10.1111/imm.13777 (Source: Immunology)
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Xiaoxuan Li Huiyan Wang Wujiang Lai Jinrong Liao Wenyu Mo Keke Huang Liqing He Xiaomei Liang Zhibin Yu Jiang Xu Xianwu Hua Fujun Hou Jun Ding William Wei-Guo Jia Kuan Zhang Yifeng Wang Source Type: research
Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids
This study analysed in vitro pro-inflammatory activity of inflammatory cytokines (TNFα and IL-1β) in a combination with a lipid DAMP molecule, oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC). The study was performed on endothelial and monocytic cell lines. The cells were treated with different concentrations of TNFα or IL-1β, OxPAPC and their combinations, either in the presence or absence of drugs regulating inflammation. Pro-inflammatory effects of TNFα/IL-1β and OxPAPC were estimated by analysis of chemokines CXCL8, CXCL2 and CXCL3 by ELISA and RT-PCR. Toxicity was determined by analysis of metabolic ...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Alma Hodzic Bernd Gesslbauer Valery Bochkov Olga V Oskolkova Source Type: research
TREM1/DAP12 based novel multiple chain CAR-T cells targeting DLL3 show robust anti-tumour efficacy for small cell lung cancer
In this study, we have developed a DLL3-TREM1/DAP12 CAR-T (DLL3-DT CAR-T) therapy, demonstrating comparable anti-tumour efficacy against SCLC cells in vitro. In murine xenograft and patient-derived xenograft models, DLL3-DT CAR-T cells exhibited a more robust tumour eradication efficiency than second-generation DLL3-BBZ CAR-T cells. Furthermore, we observed elevated memory phenotypes, induced durable responses, and activation under antigen-presenting cells in DLL3-DT CAR-T cells. Collectively, these findings suggest that DLL3-DT CAR-T cells may offer a novel and potentially effective therapeutic strategy for treating DLL3-...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Fengqi Nie Yuli Chen Yanming Hu Peng Huang Xuefei Shi Jingsheng Cai Mantang Qiu Enxiu Wang Kaihua Lu Ming Sun Source Type: research
Prevention and treatment of HPV-related cancer through a mRNA vaccine expressing APC-targeting antigen
In conclusion, this study described a therapeutic mRNA vaccine inducing strong anti-tumour immunity in peripheral and in tumour microenvironment, holding promising potential to treat HPV-induced cancer and to prevent cancer recurrence.PMID:38471664 | DOI:10.1111/imm.13777 (Source: Immunology)
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Xiaoxuan Li Huiyan Wang Wujiang Lai Jinrong Liao Wenyu Mo Keke Huang Liqing He Xiaomei Liang Zhibin Yu Jiang Xu Xianwu Hua Fujun Hou Jun Ding William Wei-Guo Jia Kuan Zhang Yifeng Wang Source Type: research
Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids
This study analysed in vitro pro-inflammatory activity of inflammatory cytokines (TNFα and IL-1β) in a combination with a lipid DAMP molecule, oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC). The study was performed on endothelial and monocytic cell lines. The cells were treated with different concentrations of TNFα or IL-1β, OxPAPC and their combinations, either in the presence or absence of drugs regulating inflammation. Pro-inflammatory effects of TNFα/IL-1β and OxPAPC were estimated by analysis of chemokines CXCL8, CXCL2 and CXCL3 by ELISA and RT-PCR. Toxicity was determined by analysis of metabolic ...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Alma Hodzic Bernd Gesslbauer Valery Bochkov Olga V Oskolkova Source Type: research
TREM1/DAP12 based novel multiple chain CAR-T cells targeting DLL3 show robust anti-tumour efficacy for small cell lung cancer
In this study, we have developed a DLL3-TREM1/DAP12 CAR-T (DLL3-DT CAR-T) therapy, demonstrating comparable anti-tumour efficacy against SCLC cells in vitro. In murine xenograft and patient-derived xenograft models, DLL3-DT CAR-T cells exhibited a more robust tumour eradication efficiency than second-generation DLL3-BBZ CAR-T cells. Furthermore, we observed elevated memory phenotypes, induced durable responses, and activation under antigen-presenting cells in DLL3-DT CAR-T cells. Collectively, these findings suggest that DLL3-DT CAR-T cells may offer a novel and potentially effective therapeutic strategy for treating DLL3-...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Fengqi Nie Yuli Chen Yanming Hu Peng Huang Xuefei Shi Jingsheng Cai Mantang Qiu Enxiu Wang Kaihua Lu Ming Sun Source Type: research
Prevention and treatment of HPV-related cancer through a mRNA vaccine expressing APC-targeting antigen
In conclusion, this study described a therapeutic mRNA vaccine inducing strong anti-tumour immunity in peripheral and in tumour microenvironment, holding promising potential to treat HPV-induced cancer and to prevent cancer recurrence.PMID:38471664 | DOI:10.1111/imm.13777 (Source: Immunology)
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Xiaoxuan Li Huiyan Wang Wujiang Lai Jinrong Liao Wenyu Mo Keke Huang Liqing He Xiaomei Liang Zhibin Yu Jiang Xu Xianwu Hua Fujun Hou Jun Ding William Wei-Guo Jia Kuan Zhang Yifeng Wang Source Type: research
Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids
This study analysed in vitro pro-inflammatory activity of inflammatory cytokines (TNFα and IL-1β) in a combination with a lipid DAMP molecule, oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC). The study was performed on endothelial and monocytic cell lines. The cells were treated with different concentrations of TNFα or IL-1β, OxPAPC and their combinations, either in the presence or absence of drugs regulating inflammation. Pro-inflammatory effects of TNFα/IL-1β and OxPAPC were estimated by analysis of chemokines CXCL8, CXCL2 and CXCL3 by ELISA and RT-PCR. Toxicity was determined by analysis of metabolic ...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Alma Hodzic Bernd Gesslbauer Valery Bochkov Olga V Oskolkova Source Type: research
TREM1/DAP12 based novel multiple chain CAR-T cells targeting DLL3 show robust anti-tumour efficacy for small cell lung cancer
In this study, we have developed a DLL3-TREM1/DAP12 CAR-T (DLL3-DT CAR-T) therapy, demonstrating comparable anti-tumour efficacy against SCLC cells in vitro. In murine xenograft and patient-derived xenograft models, DLL3-DT CAR-T cells exhibited a more robust tumour eradication efficiency than second-generation DLL3-BBZ CAR-T cells. Furthermore, we observed elevated memory phenotypes, induced durable responses, and activation under antigen-presenting cells in DLL3-DT CAR-T cells. Collectively, these findings suggest that DLL3-DT CAR-T cells may offer a novel and potentially effective therapeutic strategy for treating DLL3-...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Fengqi Nie Yuli Chen Yanming Hu Peng Huang Xuefei Shi Jingsheng Cai Mantang Qiu Enxiu Wang Kaihua Lu Ming Sun Source Type: research
Prevention and treatment of HPV-related cancer through a mRNA vaccine expressing APC-targeting antigen
In conclusion, this study described a therapeutic mRNA vaccine inducing strong anti-tumour immunity in peripheral and in tumour microenvironment, holding promising potential to treat HPV-induced cancer and to prevent cancer recurrence.PMID:38471664 | DOI:10.1111/imm.13777 (Source: Immunology)
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Xiaoxuan Li Huiyan Wang Wujiang Lai Jinrong Liao Wenyu Mo Keke Huang Liqing He Xiaomei Liang Zhibin Yu Jiang Xu Xianwu Hua Fujun Hou Jun Ding William Wei-Guo Jia Kuan Zhang Yifeng Wang Source Type: research
Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids
This study analysed in vitro pro-inflammatory activity of inflammatory cytokines (TNFα and IL-1β) in a combination with a lipid DAMP molecule, oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC). The study was performed on endothelial and monocytic cell lines. The cells were treated with different concentrations of TNFα or IL-1β, OxPAPC and their combinations, either in the presence or absence of drugs regulating inflammation. Pro-inflammatory effects of TNFα/IL-1β and OxPAPC were estimated by analysis of chemokines CXCL8, CXCL2 and CXCL3 by ELISA and RT-PCR. Toxicity was determined by analysis of metabolic ...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Alma Hodzic Bernd Gesslbauer Valery Bochkov Olga V Oskolkova Source Type: research
