CXCR3 < sup > + < /sup > effector regulatory T cells associate with disease tolerance during lower respiratory pneumovirus infection
Immunology. 2024 Apr 7. doi: 10.1111/imm.13790. Online ahead of print.ABSTRACTLifestyle factors like poor maternal diet or antibiotic exposure disrupt early life microbiome assembly in infants, increasing the risk of severe lower respiratory infections (sLRI). Our prior studies in mice indicated that a maternal low-fibre diet (LFD) exacerbates LRI severity in infants by impairing recruitment of plasmacytoid dendritic cells (pDC) and consequently attenuating expansion of lung regulatory T (Treg) cells during pneumonia virus of mice (PVM) infection. Here, we investigated whether maternal dietary fibre intake influences Treg ...
Source: Immunology - April 7, 2024 Category: Allergy & Immunology Authors: Ismail Sebina Sylvia Ngo Ridwan B Rashid Mariah Alorro Patricia Namubiru Daniel Howard Tufael Ahmed Simon Phipps Source Type: research
A review on comprehending immunotherapeutic approaches inducing ferroptosis: Managing tumour immunity
Immunology. 2024 Apr 2. doi: 10.1111/imm.13789. Online ahead of print.ABSTRACTFerroptosis, a necrotic, iron-dependent controlled cell death mechanism, is distinguished by the development of lipid peroxides to fatal proportions. Malignant tumours, influenced by iron to promote fast development, are vulnerable to ferroptosis. Based upon mounting evidence it has been observed that ferroptosis may be immunogenic and hence may complement immunotherapies. A new approach includes iron oxide-loaded nano-vaccines (IONVs), having supremacy for the traits of the tumour microenvironment (TME) to deliver specific antigens through impro...
Source: Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Soumyadeep Chattopadhyay Rudradeep Hazra Arijit Mallick Sakuntala Gayen Souvik Roy Source Type: research
A review on comprehending immunotherapeutic approaches inducing ferroptosis: Managing tumour immunity
Immunology. 2024 Apr 2. doi: 10.1111/imm.13789. Online ahead of print.ABSTRACTFerroptosis, a necrotic, iron-dependent controlled cell death mechanism, is distinguished by the development of lipid peroxides to fatal proportions. Malignant tumours, influenced by iron to promote fast development, are vulnerable to ferroptosis. Based upon mounting evidence it has been observed that ferroptosis may be immunogenic and hence may complement immunotherapies. A new approach includes iron oxide-loaded nano-vaccines (IONVs), having supremacy for the traits of the tumour microenvironment (TME) to deliver specific antigens through impro...
Source: Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Soumyadeep Chattopadhyay Rudradeep Hazra Arijit Mallick Sakuntala Gayen Souvik Roy Source Type: research
A review on comprehending immunotherapeutic approaches inducing ferroptosis: Managing tumour immunity
Immunology. 2024 Apr 2. doi: 10.1111/imm.13789. Online ahead of print.ABSTRACTFerroptosis, a necrotic, iron-dependent controlled cell death mechanism, is distinguished by the development of lipid peroxides to fatal proportions. Malignant tumours, influenced by iron to promote fast development, are vulnerable to ferroptosis. Based upon mounting evidence it has been observed that ferroptosis may be immunogenic and hence may complement immunotherapies. A new approach includes iron oxide-loaded nano-vaccines (IONVs), having supremacy for the traits of the tumour microenvironment (TME) to deliver specific antigens through impro...
Source: Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Soumyadeep Chattopadhyay Rudradeep Hazra Arijit Mallick Sakuntala Gayen Souvik Roy Source Type: research
A review on comprehending immunotherapeutic approaches inducing ferroptosis: Managing tumour immunity
Immunology. 2024 Apr 2. doi: 10.1111/imm.13789. Online ahead of print.ABSTRACTFerroptosis, a necrotic, iron-dependent controlled cell death mechanism, is distinguished by the development of lipid peroxides to fatal proportions. Malignant tumours, influenced by iron to promote fast development, are vulnerable to ferroptosis. Based upon mounting evidence it has been observed that ferroptosis may be immunogenic and hence may complement immunotherapies. A new approach includes iron oxide-loaded nano-vaccines (IONVs), having supremacy for the traits of the tumour microenvironment (TME) to deliver specific antigens through impro...
Source: Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Soumyadeep Chattopadhyay Rudradeep Hazra Arijit Mallick Sakuntala Gayen Souvik Roy Source Type: research
Radiation-induced fibrosis: Mechanisms and therapeutic strategies from an immune microenvironment perspective
This article discussed the synergetic or antagonistic effects of immune cells and mediators in regulating RIF's development. Several potential preventative and therapeutic strategies for RIF were proposed based on the immunological mechanisms to provide clinicians with improved cognition and clinical treatment guidance.PMID:38561001 | DOI:10.1111/imm.13788 (Source: Immunology)
Source: Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Mengting Zheng Zhonglong Liu Yue He Source Type: research
Radiation-induced fibrosis: Mechanisms and therapeutic strategies from an immune microenvironment perspective
This article discussed the synergetic or antagonistic effects of immune cells and mediators in regulating RIF's development. Several potential preventative and therapeutic strategies for RIF were proposed based on the immunological mechanisms to provide clinicians with improved cognition and clinical treatment guidance.PMID:38561001 | DOI:10.1111/imm.13788 (Source: Immunology)
Source: Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Mengting Zheng Zhonglong Liu Yue He Source Type: research
The dysfunction of CD8 < sup > + < /sup > T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis
In conclusion, this study revealed the global cellular variation of endometriosis among which the cellular count and physiology of EMCs and T cells were significantly changed. The depressed cytotoxicity and aberrant metabolism of CD8+ T cells were induced by ESCs with the activation of STAT1/PDCD1 pathway resulting in immune survival to promote endometriosis.PMID:38544333 | DOI:10.1111/imm.13786 (Source: Immunology)
Source: Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Zhi-Xiong Huang Dian-Chao Lin Hua-Ying Zhang Meng-Jie Yang Jia-Hao Chen Xin-Yu Ding Song-Juan Dai Yi-Huang Hong Gui-Shuang Liang Qi-Yuan Li Qiong-Hua Chen Source Type: research
GLP-1 receptor agonists alleviate colonic inflammation by modulating intestinal microbiota and the function of group 3 innate lymphoid cells
Immunology. 2024 Mar 27. doi: 10.1111/imm.13784. Online ahead of print.ABSTRACTGlucagon-like peptide-1 receptor agonists (GLP-1RAs), which are drugs used for treating type 2 diabetes, have been reported to exert anti-inflammatory effects on inflammatory bowel disease (IBD), the mechanism of which remains elusive. Here, we report that GLP-1RAs ameliorate dextran sulfate sodium (DSS)-induced colitis in both wild-type and T/B-cell-deficient mice through modulating group 3 innate lymphoid cells (ILC3s), a subset of innate lymphoid cells that regulate intestinal immunity. GLP-1RAs promote IL-22 production by ILC3, and the prote...
Source: Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Hanxiao Sun Jie Shu Jupei Tang Yue Li Jinxin Qiu Zhaoyun Ding Binbin Xuan Minghui Chen Chenxin Gan Jinpiao Lin Ju Qiu Huiming Sheng Chuanxin Wang Source Type: research
K33 only mutant ubiquitin augments bone marrow-derived dendritic cell-mediated CTL priming via PI3K-Akt pathway
Immunology. 2024 Mar 28. doi: 10.1111/imm.13787. Online ahead of print.ABSTRACTTo explore the effect of K33 only mutant ubiquitin (K33O) on bone marrow-derived dendritic cells' (BMDCs') maturity, antigen uptake capability, surface molecule expressions and BMDC-mediated CTL priming, and further investigate the role of PI3K-Akt engaged in K33O-increased BMDC maturation, antigen uptake and presentation, surface molecule expressions and BMDC-based CTL priming. BMDCs were conferred K33O and other ubiquitin mutants (K33R, K48R, K63R-mutant ubiquitin) incubation or LY294002 and wortmannin pretreatment. PI3K-Akt phosphorylation, a...
Source: Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Yi Yun Liang Xiao Yan Liao Jun Jun Jia Yi Zhen Yin Yue Hua Zhang Feng Guang Gao Source Type: research
The dysfunction of CD8 < sup > + < /sup > T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis
In conclusion, this study revealed the global cellular variation of endometriosis among which the cellular count and physiology of EMCs and T cells were significantly changed. The depressed cytotoxicity and aberrant metabolism of CD8+ T cells were induced by ESCs with the activation of STAT1/PDCD1 pathway resulting in immune survival to promote endometriosis.PMID:38544333 | DOI:10.1111/imm.13786 (Source: Immunology)
Source: Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Zhi-Xiong Huang Dian-Chao Lin Hua-Ying Zhang Meng-Jie Yang Jia-Hao Chen Xin-Yu Ding Song-Juan Dai Yi-Huang Hong Gui-Shuang Liang Qi-Yuan Li Qiong-Hua Chen Source Type: research
GLP-1 receptor agonists alleviate colonic inflammation by modulating intestinal microbiota and the function of group 3 innate lymphoid cells
Immunology. 2024 Mar 27. doi: 10.1111/imm.13784. Online ahead of print.ABSTRACTGlucagon-like peptide-1 receptor agonists (GLP-1RAs), which are drugs used for treating type 2 diabetes, have been reported to exert anti-inflammatory effects on inflammatory bowel disease (IBD), the mechanism of which remains elusive. Here, we report that GLP-1RAs ameliorate dextran sulfate sodium (DSS)-induced colitis in both wild-type and T/B-cell-deficient mice through modulating group 3 innate lymphoid cells (ILC3s), a subset of innate lymphoid cells that regulate intestinal immunity. GLP-1RAs promote IL-22 production by ILC3, and the prote...
Source: Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Hanxiao Sun Jie Shu Jupei Tang Yue Li Jinxin Qiu Zhaoyun Ding Binbin Xuan Minghui Chen Chenxin Gan Jinpiao Lin Ju Qiu Huiming Sheng Chuanxin Wang Source Type: research
K33 only mutant ubiquitin augments bone marrow-derived dendritic cell-mediated CTL priming via PI3K-Akt pathway
Immunology. 2024 Mar 28. doi: 10.1111/imm.13787. Online ahead of print.ABSTRACTTo explore the effect of K33 only mutant ubiquitin (K33O) on bone marrow-derived dendritic cells' (BMDCs') maturity, antigen uptake capability, surface molecule expressions and BMDC-mediated CTL priming, and further investigate the role of PI3K-Akt engaged in K33O-increased BMDC maturation, antigen uptake and presentation, surface molecule expressions and BMDC-based CTL priming. BMDCs were conferred K33O and other ubiquitin mutants (K33R, K48R, K63R-mutant ubiquitin) incubation or LY294002 and wortmannin pretreatment. PI3K-Akt phosphorylation, a...
Source: Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Yi Yun Liang Xiao Yan Liao Jun Jun Jia Yi Zhen Yin Yue Hua Zhang Feng Guang Gao Source Type: research
The dysfunction of CD8 < sup > + < /sup > T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis
In conclusion, this study revealed the global cellular variation of endometriosis among which the cellular count and physiology of EMCs and T cells were significantly changed. The depressed cytotoxicity and aberrant metabolism of CD8+ T cells were induced by ESCs with the activation of STAT1/PDCD1 pathway resulting in immune survival to promote endometriosis.PMID:38544333 | DOI:10.1111/imm.13786 (Source: Immunology)
Source: Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Zhi-Xiong Huang Dian-Chao Lin Hua-Ying Zhang Meng-Jie Yang Jia-Hao Chen Xin-Yu Ding Song-Juan Dai Yi-Huang Hong Gui-Shuang Liang Qi-Yuan Li Qiong-Hua Chen Source Type: research
GLP-1 receptor agonists alleviate colonic inflammation by modulating intestinal microbiota and the function of group 3 innate lymphoid cells
Immunology. 2024 Mar 27. doi: 10.1111/imm.13784. Online ahead of print.ABSTRACTGlucagon-like peptide-1 receptor agonists (GLP-1RAs), which are drugs used for treating type 2 diabetes, have been reported to exert anti-inflammatory effects on inflammatory bowel disease (IBD), the mechanism of which remains elusive. Here, we report that GLP-1RAs ameliorate dextran sulfate sodium (DSS)-induced colitis in both wild-type and T/B-cell-deficient mice through modulating group 3 innate lymphoid cells (ILC3s), a subset of innate lymphoid cells that regulate intestinal immunity. GLP-1RAs promote IL-22 production by ILC3, and the prote...
Source: Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Hanxiao Sun Jie Shu Jupei Tang Yue Li Jinxin Qiu Zhaoyun Ding Binbin Xuan Minghui Chen Chenxin Gan Jinpiao Lin Ju Qiu Huiming Sheng Chuanxin Wang Source Type: research
