Serum vitamin D deficiency is associated with increased risk of γδ T cell exhaustion in HBV-infected patients
In this study, we found that the frequency of circulating Vδ2+ T cell and serum levels of vitamin 25(OH)D3 were significantly decreased in patients with HBV. And serum 25(OH)D3 levels in HBV-infected patients were negatively correlated with HBV DNA load and PD-1 expression on γδ T cells. Interestingly, 1α,25(OH)2 D3 alleviated the exhaustion phenotype of Vδ2 T cells in HBV-infected patients and promoted IFN-β expression in human cytotoxic Vδ2 T cells in vitro. Collectively, these findings demonstrate that vitamin D plays a pivotal role in reversing γδ T-cell exhaustion and is highly promising target for ameliorati...
Source: Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Ke Li Eying Lu Qian Wang Ruirong Xu Wenhui Yuan Ruan Wu Ligong Lu Peng Li Source Type: research
Macrophage memory: Types, mechanisms, and its role in health and disease
Immunology. 2023 Sep 13. doi: 10.1111/imm.13697. Online ahead of print.ABSTRACTOn the basis of the mechanisms of action and characteristics of immune effects, immunity is commonly categorized into innate and adaptive immunity. Adaptive immunity is associated with the response to non-self-entities and is characterized by high specificity and memory properties. In contrast, innate immunity has traditionally been considered devoid of memory characteristics. However, an increasing number of studies have sought to challenge this conventional immunological dogma and shown that innate immune cells exhibit a more robust and rapid ...
Source: Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Xu-Hui Fang Zhi-Jing Li Chun-Yan Liu Gil Mor Ai-Hua Liao Source Type: research
Serum vitamin D deficiency is associated with increased risk of γδ T cell exhaustion in HBV-infected patients
In this study, we found that the frequency of circulating Vδ2+ T cell and serum levels of vitamin 25(OH)D3 were significantly decreased in patients with HBV. And serum 25(OH)D3 levels in HBV-infected patients were negatively correlated with HBV DNA load and PD-1 expression on γδ T cells. Interestingly, 1α,25(OH)2 D3 alleviated the exhaustion phenotype of Vδ2 T cells in HBV-infected patients and promoted IFN-β expression in human cytotoxic Vδ2 T cells in vitro. Collectively, these findings demonstrate that vitamin D plays a pivotal role in reversing γδ T-cell exhaustion and is highly promising target for ameliorati...
Source: Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Ke Li Eying Lu Qian Wang Ruirong Xu Wenhui Yuan Ruan Wu Ligong Lu Peng Li Source Type: research
Macrophage memory: Types, mechanisms, and its role in health and disease
Immunology. 2023 Sep 13. doi: 10.1111/imm.13697. Online ahead of print.ABSTRACTOn the basis of the mechanisms of action and characteristics of immune effects, immunity is commonly categorized into innate and adaptive immunity. Adaptive immunity is associated with the response to non-self-entities and is characterized by high specificity and memory properties. In contrast, innate immunity has traditionally been considered devoid of memory characteristics. However, an increasing number of studies have sought to challenge this conventional immunological dogma and shown that innate immune cells exhibit a more robust and rapid ...
Source: Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Xu-Hui Fang Zhi-Jing Li Chun-Yan Liu Gil Mor Ai-Hua Liao Source Type: research
Flot2 deficiency facilitates B cell-mediated inflammatory responses and endotoxic shock
Immunology. 2023 Sep 8. doi: 10.1111/imm.13692. Online ahead of print.ABSTRACTSepsis is a life-threatening disease characterized by multiple organ dysfunction. B cells play a pivotal role in sepsis. Here, we first observed the significantly reduced Flot2 gene expression in B cells from patients with bacterial sepsis and endotoxin-induced septic mice. However, the effects of Flot2 on sepsis and B-cell immunity remain unknown. Thus, we sorted B cells from Flot2 knockout (Flot2-/- ) mice, RNA-seq revealed significantly upregulated effector B cell (Beff) cytokines such as Il6, Il1b and Cxcl10 after Flot2 deficiency, while it s...
Source: Immunology - September 9, 2023 Category: Allergy & Immunology Authors: Qin Yang Zhenhua Zhang Ziye Chen Yiyuan Wang Yan Chen Jiehuang Zheng Ruopeng Li Lihong Li Lixia Mo Qinghe Liang Fengsheng Chen Junjian Wang Xiaojuan Li Source Type: research
Dysregulation of B lymphocyte development in the SKG mouse model of rheumatoid arthritis
Immunology. 2023 Sep 9. doi: 10.1111/imm.13691. Online ahead of print.ABSTRACTRheumatoid arthritis is a chronic and systemic inflammatory disease that affects approximately 1% of the world's population and is characterised by joint inflammation, the destruction of articular cartilage and bone, and many potentially life-threatening extraarticular manifestations. B lymphocytes play a central role in the pathology of rheumatoid arthritis as the precursors of autoantibody secreting plasma cells, as highly potent antigen-presenting cells, and as a source of various inflammatory cytokines, however, the effects of rheumatoid arth...
Source: Immunology - September 9, 2023 Category: Allergy & Immunology Authors: Joo Eun June Kim Lin Tze Tung Roselyn R Jiang Mitra Yousefi Yue Liang Danielle Malo Silvia M Vidal Anastasia Nijnik Source Type: research
Flot2 deficiency facilitates B cell-mediated inflammatory responses and endotoxic shock
Immunology. 2023 Sep 8. doi: 10.1111/imm.13692. Online ahead of print.ABSTRACTSepsis is a life-threatening disease characterized by multiple organ dysfunction. B cells play a pivotal role in sepsis. Here, we first observed the significantly reduced Flot2 gene expression in B cells from patients with bacterial sepsis and endotoxin-induced septic mice. However, the effects of Flot2 on sepsis and B-cell immunity remain unknown. Thus, we sorted B cells from Flot2 knockout (Flot2-/- ) mice, RNA-seq revealed significantly upregulated effector B cell (Beff) cytokines such as Il6, Il1b and Cxcl10 after Flot2 deficiency, while it s...
Source: Immunology - September 9, 2023 Category: Allergy & Immunology Authors: Qin Yang Zhenhua Zhang Ziye Chen Yiyuan Wang Yan Chen Jiehuang Zheng Ruopeng Li Lihong Li Lixia Mo Qinghe Liang Fengsheng Chen Junjian Wang Xiaojuan Li Source Type: research
Dysregulation of B lymphocyte development in the SKG mouse model of rheumatoid arthritis
Immunology. 2023 Sep 9. doi: 10.1111/imm.13691. Online ahead of print.ABSTRACTRheumatoid arthritis is a chronic and systemic inflammatory disease that affects approximately 1% of the world's population and is characterised by joint inflammation, the destruction of articular cartilage and bone, and many potentially life-threatening extraarticular manifestations. B lymphocytes play a central role in the pathology of rheumatoid arthritis as the precursors of autoantibody secreting plasma cells, as highly potent antigen-presenting cells, and as a source of various inflammatory cytokines, however, the effects of rheumatoid arth...
Source: Immunology - September 9, 2023 Category: Allergy & Immunology Authors: Joo Eun June Kim Lin Tze Tung Roselyn R Jiang Mitra Yousefi Yue Liang Danielle Malo Silvia M Vidal Anastasia Nijnik Source Type: research
Flot2 deficiency facilitates B cell-mediated inflammatory responses and endotoxic shock
Immunology. 2023 Sep 8. doi: 10.1111/imm.13692. Online ahead of print.ABSTRACTSepsis is a life-threatening disease characterized by multiple organ dysfunction. B cells play a pivotal role in sepsis. Here, we first observed the significantly reduced Flot2 gene expression in B cells from patients with bacterial sepsis and endotoxin-induced septic mice. However, the effects of Flot2 on sepsis and B-cell immunity remain unknown. Thus, we sorted B cells from Flot2 knockout (Flot2-/- ) mice, RNA-seq revealed significantly upregulated effector B cell (Beff) cytokines such as Il6, Il1b and Cxcl10 after Flot2 deficiency, while it s...
Source: Immunology - September 9, 2023 Category: Allergy & Immunology Authors: Qin Yang Zhenhua Zhang Ziye Chen Yiyuan Wang Yan Chen Jiehuang Zheng Ruopeng Li Lihong Li Lixia Mo Qinghe Liang Fengsheng Chen Junjian Wang Xiaojuan Li Source Type: research
Dysregulation of B lymphocyte development in the SKG mouse model of rheumatoid arthritis
Immunology. 2023 Sep 9. doi: 10.1111/imm.13691. Online ahead of print.ABSTRACTRheumatoid arthritis is a chronic and systemic inflammatory disease that affects approximately 1% of the world's population and is characterised by joint inflammation, the destruction of articular cartilage and bone, and many potentially life-threatening extraarticular manifestations. B lymphocytes play a central role in the pathology of rheumatoid arthritis as the precursors of autoantibody secreting plasma cells, as highly potent antigen-presenting cells, and as a source of various inflammatory cytokines, however, the effects of rheumatoid arth...
Source: Immunology - September 9, 2023 Category: Allergy & Immunology Authors: Joo Eun June Kim Lin Tze Tung Roselyn R Jiang Mitra Yousefi Yue Liang Danielle Malo Silvia M Vidal Anastasia Nijnik Source Type: research
Flot2 deficiency facilitates B cell-mediated inflammatory responses and endotoxic shock
Immunology. 2023 Sep 8. doi: 10.1111/imm.13692. Online ahead of print.ABSTRACTSepsis is a life-threatening disease characterized by multiple organ dysfunction. B cells play a pivotal role in sepsis. Here, we first observed the significantly reduced Flot2 gene expression in B cells from patients with bacterial sepsis and endotoxin-induced septic mice. However, the effects of Flot2 on sepsis and B-cell immunity remain unknown. Thus, we sorted B cells from Flot2 knockout (Flot2-/- ) mice, RNA-seq revealed significantly upregulated effector B cell (Beff) cytokines such as Il6, Il1b and Cxcl10 after Flot2 deficiency, while it s...
Source: Immunology - September 9, 2023 Category: Allergy & Immunology Authors: Qin Yang Zhenhua Zhang Ziye Chen Yiyuan Wang Yan Chen Jiehuang Zheng Ruopeng Li Lihong Li Lixia Mo Qinghe Liang Fengsheng Chen Junjian Wang Xiaojuan Li Source Type: research
Dysregulation of B lymphocyte development in the SKG mouse model of rheumatoid arthritis
Immunology. 2023 Sep 9. doi: 10.1111/imm.13691. Online ahead of print.ABSTRACTRheumatoid arthritis is a chronic and systemic inflammatory disease that affects approximately 1% of the world's population and is characterised by joint inflammation, the destruction of articular cartilage and bone, and many potentially life-threatening extraarticular manifestations. B lymphocytes play a central role in the pathology of rheumatoid arthritis as the precursors of autoantibody secreting plasma cells, as highly potent antigen-presenting cells, and as a source of various inflammatory cytokines, however, the effects of rheumatoid arth...
Source: Immunology - September 9, 2023 Category: Allergy & Immunology Authors: Joo Eun June Kim Lin Tze Tung Roselyn R Jiang Mitra Yousefi Yue Liang Danielle Malo Silvia M Vidal Anastasia Nijnik Source Type: research
Celiprolol and sympatho-immune interface in COVID-19
Immunology. 2023 Sep 7. doi: 10.1111/imm.13693. Online ahead of print.NO ABSTRACTPMID:37679864 | DOI:10.1111/imm.13693 (Source: Immunology)
Source: Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Hayder M Al-Kuraishy Ali K Albuhadily Ali I Al-Gareeb Maisra M El-Bouseary Athanasios Alexiou Marios Papadakis Gaber El-Saber Batiha Source Type: research
Celiprolol and sympatho-immune interface in COVID-19
Immunology. 2023 Sep 7. doi: 10.1111/imm.13693. Online ahead of print.NO ABSTRACTPMID:37679864 | DOI:10.1111/imm.13693 (Source: Immunology)
Source: Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Hayder M Al-Kuraishy Ali K Albuhadily Ali I Al-Gareeb Maisra M El-Bouseary Athanasios Alexiou Marios Papadakis Gaber El-Saber Batiha Source Type: research
Interleukin-7 improves the fitness of regulatory T cells for adoptive transfer
In conclusion, our data demonstrate the feasibility of expanding naïve Treg in the presence of IL-7 to generate a Treg product enriched in poorly differentiated CD45RA+ cells with enhanced survival capabilities.PMID:37671510 | DOI:10.1111/imm.13690 (Source: Immunology)
Source: Immunology - September 6, 2023 Category: Allergy & Immunology Authors: Ilaria Cosorich Jessica Filoni Carla Di Dedda Arianna Ferrari Tatiana Jofra Susanna Cesarano Chiara Bonini Lorenzo Piemonti Paolo Monti Source Type: research
