Impact of sex differences on the clinical presentation, pathogenesis, treatment and prognosis of Sj ögren's syndrome
Immunology. 2023 Dec 29. doi: 10.1111/imm.13740. Online ahead of print.ABSTRACTSjögren's syndrome is a common chronic autoimmune disease that manifests as dry mouth, dry eyes and systemic complications. There are sex differences in the clinical manifestations between men and women, with the average age of onset being around 55 years and the majority of female patients developing the disease during the menopausal years. Understanding the impact of sex differences on SS may help in the treatment and prognosis of patients. Studies have confirmed that a number of factors are associated with the onset of SS, but the exact mech...
Source: Immunology - December 29, 2023 Category: Allergy & Immunology Authors: Yuhao Xuan Xiao Zhang Huaxun Wu Source Type: research
Impact of sex differences on the clinical presentation, pathogenesis, treatment and prognosis of Sj ögren's syndrome
Immunology. 2023 Dec 29. doi: 10.1111/imm.13740. Online ahead of print.ABSTRACTSjögren's syndrome is a common chronic autoimmune disease that manifests as dry mouth, dry eyes and systemic complications. There are sex differences in the clinical manifestations between men and women, with the average age of onset being around 55 years and the majority of female patients developing the disease during the menopausal years. Understanding the impact of sex differences on SS may help in the treatment and prognosis of patients. Studies have confirmed that a number of factors are associated with the onset of SS, but the exact mech...
Source: Immunology - December 29, 2023 Category: Allergy & Immunology Authors: Yuhao Xuan Xiao Zhang Huaxun Wu Source Type: research
Impact of sex differences on the clinical presentation, pathogenesis, treatment and prognosis of Sj ögren's syndrome
Immunology. 2023 Dec 29. doi: 10.1111/imm.13740. Online ahead of print.ABSTRACTSjögren's syndrome is a common chronic autoimmune disease that manifests as dry mouth, dry eyes and systemic complications. There are sex differences in the clinical manifestations between men and women, with the average age of onset being around 55 years and the majority of female patients developing the disease during the menopausal years. Understanding the impact of sex differences on SS may help in the treatment and prognosis of patients. Studies have confirmed that a number of factors are associated with the onset of SS, but the exact mech...
Source: Immunology - December 29, 2023 Category: Allergy & Immunology Authors: Yuhao Xuan Xiao Zhang Huaxun Wu Source Type: research
Single-cell profiling of bronchoalveolar cells reveals a Th17 signature in neutrophilic severe equine asthma
Immunology. 2023 Dec 28. doi: 10.1111/imm.13745. Online ahead of print.ABSTRACTSevere equine asthma (SEA) is a complex respiratory condition characterized by chronic airway inflammation. It shares many clinical and pathological features with human neutrophilic asthma, making it a valuable model for studying this condition. However, the immune mechanisms driving SEA have remained elusive. Although SEA has been primarily associated with a Th2 response, there have also been reports of Th1, Th17, or mixed-mediated responses. To uncover the elusive immune mechanisms driving SEA, we performed single-cell mRNA sequencing (scRNA-s...
Source: Immunology - December 28, 2023 Category: Allergy & Immunology Authors: Sophie E Sage Tosso Leeb Vidhya Jagannathan Vinzenz Gerber Source Type: research
Single-cell profiling of bronchoalveolar cells reveals a Th17 signature in neutrophilic severe equine asthma
Immunology. 2023 Dec 28. doi: 10.1111/imm.13745. Online ahead of print.ABSTRACTSevere equine asthma (SEA) is a complex respiratory condition characterized by chronic airway inflammation. It shares many clinical and pathological features with human neutrophilic asthma, making it a valuable model for studying this condition. However, the immune mechanisms driving SEA have remained elusive. Although SEA has been primarily associated with a Th2 response, there have also been reports of Th1, Th17, or mixed-mediated responses. To uncover the elusive immune mechanisms driving SEA, we performed single-cell mRNA sequencing (scRNA-s...
Source: Immunology - December 28, 2023 Category: Allergy & Immunology Authors: Sophie E Sage Tosso Leeb Vidhya Jagannathan Vinzenz Gerber Source Type: research
High TSLP responses in the human infant airways are associated with pre-activated airway epithelial IFN antiviral immunity
Immunology. 2023 Dec 26. doi: 10.1111/imm.13741. Online ahead of print.ABSTRACTThymic stromal lymphopoietin (TSLP) is a primarily epithelial-derived cytokine that drives type 2 allergic immune responses. Early life viral respiratory infections elicit high TSLP production, which leads to the development of type 2 inflammation and airway hyperreactivity. The goal of this study was to examine in vivo and in vitro the human airway epithelial responses leading to high TSLP production during viral respiratory infections in early infancy. A total of 129 infants (<1-24 m, median age 10 m) with severe viral respiratory infection...
Source: Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Allison Welham Elizabeth Chorvinsky Surajit Bhattacharya Betelehem Solomon Bera Kyle Salka Jered Weinstock Xilei Xu Chen Geovanny F Perez Dinesh K Pillai Maria J Gutierrez Hiroki Morizono Jyoti Jaiswal Gustavo Nino Source Type: research
Comparison of the stability of glycoprotein acetyls and high sensitivity C-reactive protein as markers of chronic inflammation
This study showed that GlycA has greater long-term stability than hsCRP, however associations of proinflammatory factors with GlycA and hsCRP were broadly similar.PMID:38148627 | DOI:10.1111/imm.13739 (Source: Immunology)
Source: Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Daisy C P Crick Golam M Khandaker Sarah L Halligan David Burgner Toby Mansell Abigail Fraser Source Type: research
How to improve translatability and clinical relevance of preclinical studies in rheumatoid arthritis
Immunology. 2023 Dec 26. doi: 10.1111/imm.13746. Online ahead of print.NO ABSTRACTPMID:38148686 | DOI:10.1111/imm.13746 (Source: Immunology)
Source: Immunology - December 27, 2023 Category: Allergy & Immunology Authors: George D Kalliolias Efthimia K Basdra Athanasios G Papavassiliou Source Type: research
TLR7 enhancing follicular helper T (Tfh) cells response in C57BL/6 mice infected with Plasmodium yoelii NSM TLR7 mediated Tfh cells in P. yoelii infected mice
Immunology. 2023 Dec 27. doi: 10.1111/imm.13736. Online ahead of print.ABSTRACTToll-like receptors (TLRs) play an important role in inducing innate and acquired immune responses against infection. However, the effect of Toll-like receptor 7 (TLR7) on follicular helper T (Tfh) cells in mice infected with Plasmodium is still not clear. The results showed that the splenic CD4+ CXCR5+ PD-1+ Tfh cells were accumulated after Plasmodium yoelii NSM infection, the content of splenic Tfh cells was correlated to parasitemia and/or the red blood cells (RBCs) counts in the blood. Moreover, the expression of TLR7 was found higher than T...
Source: Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Quan Yang Lu Zhou Zhengrong Tan Yiqiang Zhu Lengshan Mo Chao Fang Jiajie Li Chen Chen Ying Luo Haixia Wei Weiguo Yin Jun Huang Source Type: research
High TSLP responses in the human infant airways are associated with pre-activated airway epithelial IFN antiviral immunity
Immunology. 2023 Dec 26. doi: 10.1111/imm.13741. Online ahead of print.ABSTRACTThymic stromal lymphopoietin (TSLP) is a primarily epithelial-derived cytokine that drives type 2 allergic immune responses. Early life viral respiratory infections elicit high TSLP production, which leads to the development of type 2 inflammation and airway hyperreactivity. The goal of this study was to examine in vivo and in vitro the human airway epithelial responses leading to high TSLP production during viral respiratory infections in early infancy. A total of 129 infants (<1-24 m, median age 10 m) with severe viral respiratory infection...
Source: Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Allison Welham Elizabeth Chorvinsky Surajit Bhattacharya Betelehem Solomon Bera Kyle Salka Jered Weinstock Xilei Xu Chen Geovanny F Perez Dinesh K Pillai Maria J Gutierrez Hiroki Morizono Jyoti Jaiswal Gustavo Nino Source Type: research
Comparison of the stability of glycoprotein acetyls and high sensitivity C-reactive protein as markers of chronic inflammation
This study showed that GlycA has greater long-term stability than hsCRP, however associations of proinflammatory factors with GlycA and hsCRP were broadly similar.PMID:38148627 | DOI:10.1111/imm.13739 (Source: Immunology)
Source: Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Daisy C P Crick Golam M Khandaker Sarah L Halligan David Burgner Toby Mansell Abigail Fraser Source Type: research
How to improve translatability and clinical relevance of preclinical studies in rheumatoid arthritis
Immunology. 2023 Dec 26. doi: 10.1111/imm.13746. Online ahead of print.NO ABSTRACTPMID:38148686 | DOI:10.1111/imm.13746 (Source: Immunology)
Source: Immunology - December 27, 2023 Category: Allergy & Immunology Authors: George D Kalliolias Efthimia K Basdra Athanasios G Papavassiliou Source Type: research
Engineered polyspecific antibodies: A new frontier in the field of immunotherapeutics
Immunology. 2023 Dec 23. doi: 10.1111/imm.13743. Online ahead of print.ABSTRACTThe 21st-century beginning remarked with the huge success of monospecific MAbs, however, in the last couple of years, polyspecific MAbs (PsAbs) have been an interesting topic and show promise of being biobetter than monospecific MAbs. Polyspecificity, in which a single antibody serves multiple specific target binding, has been hypothesized to contribute to the development of a highly effective antibody repertoire for immune defence. This polyspecific MAb trend represents an explosion that is gripping the whole pharmaceutical industry. This revie...
Source: Immunology - December 23, 2023 Category: Allergy & Immunology Authors: None Sandeep Suraj H Shinde Sakeel Ahmed Shyam Sunder Sharma Abhay H Pande Source Type: research
Engineered polyspecific antibodies: A new frontier in the field of immunotherapeutics
Immunology. 2023 Dec 23. doi: 10.1111/imm.13743. Online ahead of print.ABSTRACTThe 21st-century beginning remarked with the huge success of monospecific MAbs, however, in the last couple of years, polyspecific MAbs (PsAbs) have been an interesting topic and show promise of being biobetter than monospecific MAbs. Polyspecificity, in which a single antibody serves multiple specific target binding, has been hypothesized to contribute to the development of a highly effective antibody repertoire for immune defence. This polyspecific MAb trend represents an explosion that is gripping the whole pharmaceutical industry. This revie...
Source: Immunology - December 23, 2023 Category: Allergy & Immunology Authors: None Sandeep Suraj H Shinde Sakeel Ahmed Shyam Sunder Sharma Abhay H Pande Source Type: research
Engineered polyspecific antibodies: A new frontier in the field of immunotherapeutics
Immunology. 2023 Dec 23. doi: 10.1111/imm.13743. Online ahead of print.ABSTRACTThe 21st-century beginning remarked with the huge success of monospecific MAbs, however, in the last couple of years, polyspecific MAbs (PsAbs) have been an interesting topic and show promise of being biobetter than monospecific MAbs. Polyspecificity, in which a single antibody serves multiple specific target binding, has been hypothesized to contribute to the development of a highly effective antibody repertoire for immune defence. This polyspecific MAb trend represents an explosion that is gripping the whole pharmaceutical industry. This revie...
Source: Immunology - December 23, 2023 Category: Allergy & Immunology Authors: None Sandeep Suraj H Shinde Sakeel Ahmed Shyam Sunder Sharma Abhay H Pande Source Type: research
