PNPLA3, obesity and heavy alcohol use in cirrhosis patients may exert a synergistic increase hepatocellular carcinoma risk
We examined whether germline susceptibility to hepatic steatosis not only independently predisposes to HCC but may also act synergistically with other risk factors. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Aaron P. Thrift, Fasiha Kanwal, Hyeyeun Lim, Hao Duong, Yanhong Liu, Amit G. Singal, Saira Khaderi, Sumeet K. Asrani, Christopher I. Amos, Hashem B. El-Serag Source Type: research

Breastfeeding duration is not associated with offspring inflammatory bowel disease risk in three population-based birth cohorts
Breastfeeding is critical for offspring health and development. While many observational studies report a protective effect between breastfeeding and inflammatory bowel disease (IBD), the relationship is not well-understood. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Manasi Agrawal, Ketil St ørdal, Anne Vinkel Hansen, Malin Östensson, Maiara Brusco De Freitas, Kristine H. Allin, Tine Jess, Johnny Ludvigsson, Karl Mårild Source Type: research

Long-term outcome of risankizumab in Crohn ’s disease: a real-world GETAID study
The aim of this study was to assess the long-term effectiveness and safety of risankizumab maintenance treatment in a large real-world cohort of patients with CD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Mathurin Fumery, Benedicte Caron, Xavier H ébuterne, Romain Altwegg, Xavier Roblin, Carmen Stefanescu, Antoine Meyer, Maria Nachury, David Laharie, Catherine Le Berre, Lucas Guillo, Amélie Biron, Ludovic Caillo, Anthony Buisson, Stephane Nancey, Mathieu Source Type: research

Effects of Thiopurine Withdrawal on Vedolizumab-Treated Patients With Ulcerative Colitis: a Randomized Controlled Trial
The impact of thiopurine de-escalation whilst on vedolizumab versus continuing thiopurine therapy in ulcerative colitis (UC) is unclear. We aimed to determine the effect of thiopurine withdrawal for patients with UC in remission on vedolizumab. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Aviv Pudipeddi, Sudarshan Paramsothy, Viraj Kariyawasam, Ramesh Paramsothy, Simon Ghaly, Craig Haifer, Yoon-Kyo An, Jakob Begun, Susan J. Connor, Crispin Corte, Mark G. Ward, Peter De Cruz, Caroline Lan-San Fung, Diane Redmond, Webber Chan, Fadi Mourad, M Source Type: research

ChatGPT4 outperforms endoscopists for determination of post-colonoscopy re-screening and surveillance recommendations
In this study, we aim to compare the accuracy, concordance and reliability of ChatGPT4 colonoscopy recommendations for colorectal cancer re-screening and surveillance to contemporary guidelines and real-world gastroenterology practice. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Patrick W. Chang, Maziar M. Amini, Rio O. Davis, Denis D. Nguyen, Jennifer L. Dodge, Helen Lee, Sarah Sheibani, Jennifer Phan, James L. Buxbaum, Ara B. Sahakian Source Type: research

High prevalence and clinical relevance of intrapulmonary vascular dilatations in patients undergoing TIPS implantation
Considerate patient selection is vital to ensure best possible outcomes after transjugular intrahepatic portosystemic shunt (TIPS) insertion. However, data regarding the impact of intrapulmonary vascular dilatations (IPVD) or hepatopulmonary syndrome (HPS) on the clinical course after TIPS implantation is lacking. Hence, this study aimed to investigate the relevance of IPVD and HPS in patients undergoing TIPS implantation. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Jim B. Mauz, Hannah Schneider, Dominik Berliner, Anja Tiede, Lena Stockhoff, Jan B. Hinrichs, Heiner Wedemeyer, Bernhard C. Meyer, Karen M. Olsson, Benjamin Maasoumy, Tammo L. Tergast Source Type: research

Early-Onset Colorectal Cancer Patients Do Not Require Shorter Intervals for Post-Surgical Surveillance Colonoscopy
Early-onset colorectal cancer (EO-CRC), diagnosed before age 50, is rising in incidence worldwide. Although post-surgical colonoscopy surveillance strategies exist, appropriate intervals in EO-CRC remain elusive, as long-term surveillance outcomes remain scant. We sought to compare findings of surveillance colonoscopies of EO-CRC to average onset colorectal cancer (AO-CRC) patients to help define surveillance outcomes in these groups. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Robin B. Mendelsohn, Anne I. Hahn, Randze Lerie Palmaira, Asha R. Saxena, Pavan Kedar Mukthinuthalapati, Mark A. Schattner, Arnold J. Markowitz, Emmy Ludwig, Pari Shah, Delia Calo, Hans Gerdes, Rona Yaeger, Zsofia Stadler, Ann G. Zauber, Andrea Cercek Source Type: research

Re-evaluating the proposed association between vonoprazan and gastric cancer following eradication of H. pylori infection
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Colin W. Howden, William D. Chey, Shailja C. Shah Tags: Letter to the Editor Source Type: research

Guarding the Gate: The Sentinel Role of Endosonograpy in Precluding Unwarranted ERCP
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Fateh Bazerbachi, Eisuke Iwasaki, Masayasu Horibe Tags: Letter to the Editor Source Type: research

All FODMAPs aren ’t created equal: Results of a randomized reintroduction trial in patients with irritable bowel syndrome
A diet low in fermentable oligo, di, monosaccharides and polyols (FODMAPs) is one of the recommended management strategies for irritable bowel syndrome (IBS). However, while effective, adherence to restricting dietary FODMAPs can be challenging and burdensome. The question remains whether limiting all FODMAPs during the restrictive phase of the diet is necessary for symptomatic improvement in the dietary treatment of IBS, or if targeting selected groups of FODMAPs for restriction is sufficient for clinical response. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Shanti Eswaran, Kara J. Jencks, Prashant Singh, Samara Rifkin, Theresa Han-Markey, William D. Chey Source Type: research

Can endoscopic ultrasound-guided ablation prolong disease-specific survival in pancreatic cysts?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Yousuke Nakai, Tsuyoshi Hamada, Hiroki Oyama Tags: Letter to the Editor Source Type: research

Safety and Efficacy of Novel Incretin Co-agonist Cotadutide in Biopsy-proven Non-cirrhotic MASH with Fibrosis
Cotadutide, a peptide co-agonist at the glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptors has demonstrated robust improvements in body weight, glycemia, and hepatic fat fraction (HFF) in patients living with obesity and type 2 diabetes mellitus. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Sudha S. Shankar, Samuel J. Daniels, Darren Robertson, Janeli Sarv, Jos é Sánchez, Debra Carter, Lutz Jermutus, Benjamin Challis, Arun J. Sanyal Source Type: research

Is a simplified, less restrictive low FODMAP diet possible? Results from a double-blind, pilot randomized controlled trial.
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Prashant Singh, Samuel W. Chey, Judy Nee, Shanti Eswaran, The Dietary Therapy in IBS Working Group Tags: Research Letter Source Type: research

Chronic hepatitis C related steatotic liver disease is more than “miscellaneous steatotic liver disease”
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Chung-Feng Huang, Ming-Lun Yeh, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Ming-Lung Yu Tags: Research Letter Source Type: research

Early liver transplant for alcohol-associated liver disease has excellent survival but higher rates of harmful alcohol use
Early liver transplantation for alcohol-associated liver disease (ALD) has increased worldwide. Short-term outcomes have been favorable, but data on longer-term outcomes are lacking. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 8, 2024 Category: Gastroenterology Authors: Jessica A. Musto, Geralyn Palmer, Mary Nemer, Trevor Schell, Gabrielle Waclawik, Quarshie Glover, Michael R. Lucey, Fay Osman, John P. Rice Source Type: research