Targeting Dectin-1 and or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model
ConclusionOur study proposes Dectin-1 as a potential adjunctive target with ICBs, orchestrating a comprehensive engagement of innate and adaptive immune responses in melanoma. This innovative approach holds promise for overcoming acquired resistance to ICBs in cancer treatment, offering avenues for further exploration and development. (Source: Cellular Oncology)
Source: Cellular Oncology - April 26, 2024 Category: Cancer & Oncology Source Type: research
Rituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion
ConclusionRituximab combined with CAR-T therapy is effective for improving the long-term prognosis of B-ALL patients who have failed multiple lines of therapy. In vitro, we observed that rituximab potentially improves CAR-T efficacy by sensitizing ALL to CART-mediated cytotoxicity and reducing CAR-T exhaustion. (Source: Cellular Oncology)
Source: Cellular Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
LILRB2 promotes immune escape in breast cancer cells via enhanced HLA-A degradation
ConclusionLILRB2 downregulates HLA-A to promote immune evasion in BC cells and is a promising new target for BC treatment. (Source: Cellular Oncology)
Source: Cellular Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis
ConclusionsscRNA-seq illuminated the activation of the PDGF signaling pathway in primary lesion of non-metastatic osteosarcoma. PDGFD displayed an inhibitory effect on osteosarcoma metastasis, likely through the suppression of the EMT signaling pathway. (Source: Cellular Oncology)
Source: Cellular Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Chordoma cells possess bone-dissolving activity at the bone invasion front
ConclusionIn chordoma, we propose that in addition to conventional bone resorption by osteoclasts, chordoma cells possess bone-dissolving activity at the tumor-bone boundary. Furthermore, bone destruction and tumor expansion may occur in a positive feedback loop. (Source: Cellular Oncology)
Source: Cellular Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Correction to: Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
(Source: Cellular Oncology)
Source: Cellular Oncology - April 16, 2024 Category: Cancer & Oncology Source Type: research
Establishment, characterization, and biobanking of 36 pancreatic cancer organoids: prediction of metastasis in resectable pancreatic cancer
ConclusionsThese data suggest that the presence of metastatic PDAC can be identified by integrating molecular compositions and drug responses of borderline resectable PDAC. (Source: Cellular Oncology)
Source: Cellular Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
The emerging role of CARM1 in cancer
AbstractCoactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing arginine methylation of histone and non-histone proteins, plays a crucial role in developing various cancers. CARM1 was initially recognized as a transcriptional coregulator by orchestrating chromatin remodeling, transcription regulation, mRNA splicing and stability. This diverse functionality contributes to the recruitment of transcription factors that foster malignancies. Going beyond its established involvement in transcriptional control, CARM1-mediated methylation influences a spectrum of biological processes, including the cell...
Source: Cellular Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals immune suppression subtypes and establishes a novel signature for determining the prognosis in lung adenocarcinoma
ConclusionsOur multi-omics result revealed a comprehensive set of molecular attributes associated with prognosis-related genes in LUAD at the cellular and tissue level. Identification of a subtype of immunosuppressive TME and prognostic signature for LUAD. We identified the cell cycle regulation geneCDC25C affects lung cancer cell invasion and migration, which can be used as a potential biomarker for LUAD. (Source: Cellular Oncology)
Source: Cellular Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
ConclusionThe findings from this study demonstrate the anticancer activity of GPX8 in HCC by inactivating the Hsc70/AKT pathway. The results suggest a possible therapeutic target for HCC. (Source: Cellular Oncology)
Source: Cellular Oncology - April 12, 2024 Category: Cancer & Oncology Source Type: research
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling
ConclusionDEX promotes CRC progression may via activating α2 adrenoceptor-dependent Nrf2/Piwil2/Siah2 pathway and thus EMT process. Our work provides a novel insight into the mechanism underlying tumor-promoting effects of α2-adrenoceptor agonists. (Source: Cellular Oncology)
Source: Cellular Oncology - April 9, 2024 Category: Cancer & Oncology Source Type: research
Hedgehog ligand and receptor cooperatively regulate EGFR stability and activity in non-small cell lung cancer
ConclusionNon-canonical Hh signaling pathway, involving cooperation between Hh ligands and their receptor Ptch1, facilitates the degradation of EGFR and attenuates its activity in NSCLC. These findings provide novel insights into the regulation of EGFR protein stability and activity, offer new diagnostic indicators for molecular typing of NSCLC and identify potential targets for targeted therapy of this challenging disease. (Source: Cellular Oncology)
Source: Cellular Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Efficacy of programmed cell death 1 inhibitor maintenance after chimeric antigen receptor T cells in patients with relapsed/refractory B-cell non-Hodgkin-lymphoma
ConclusionPD1 inhibitor maintenance following CD19/22 CAR-T therapy obtained superior response and survival in r/r B-NHL, but not in the trial of CD19/22 CAR-T cell therapy combined with ASCT. (Source: Cellular Oncology)
Source: Cellular Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
Copy number signatures and CCNE1 amplification reveal the involvement of replication stress in high-grade endometrial tumors oncogenesis
ConclusionThe identification ofCCNE1 amplification, which is currently being explored as a therapeutic target in clinical trials, suggests new treatment strategies for high-grade endometrial cancer. This finding holds particular significance for Martinique, where access to care is challenging. (Source: Cellular Oncology)
Source: Cellular Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/ β-catenin signaling
ConclusionsOur data indicate that IFIT1 increases pancreatic cancer cell proliferation, migration and invasion by activating the Wnt/ β-catenin pathway. In addition, we found that EMT could be regulated by IFIT1. IFIT1 may serve as a potential therapeutic target for pancreatic cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - March 27, 2024 Category: Cancer & Oncology Source Type: research
